The Department of Experimental Biomedicine at the

Rudolf Virchow Center/University Hospital Würzburg invites applications for a

Postdoc position (f/m/d)

“Protein-protein interactions in platelet receptor signaling”

Platelets are small anucleated blood cells that survey the integrity of the vessel wall and play a critical role in hemostasis, thrombosis as well as thrombo-inflammatory and malignant disease. Platelet activation, adhesion and exocrine function must be controlled with high fidelity to ensure the various/different physiological functions of these highly versatile cells.

The Würzburg Platelet Group studies platelet membrane glycoproteins and their downstream signaling pathways at all levels of complexity ranging from single molecule analyses to studies in murine disease models and clinical cohorts. In the framework of the newly established DFG-funded Collaborative Research Centre/Transregio (CRC/TR) 240  “PLATELETS” we use a large array of technologies to identify and validate novel targets to interfere with pathological platelet function, including “omics”, bioinformatics, mouse genetics, advanced microscopy techniques and protein engineering. We closely collaborate with the pharmaceutical industry to further develop biologics for clinical application.

Activities and responsibilities

The project will focus on studying protein-protein interactions in platelet receptor signaling with the aim to identify and structurally/functionally characterize interaction partners of platelet receptor ectodomains as well as intracellular key signaling molecules. You will work with cellular expression systems, biochemistry, structural biology, and the local Proteomics platform. As a postdoctoral fellow in our group you will drive your own research project and collaborate closely with other group members, as well as local and international collaboration partners. You will furthermore engage in (co-)supervising PhD students and teaching activities.

You have / Qualification profile

Suitable candidates should hold a doctoral degree in biochemistry, chemistry, pharmacy, biology or a related field, profound skills in molecular cloning and protein expression was well as a strong interest in translational disease-oriented research. Excellent knowledge of the English language is a prerequisite. Previous experience with (preferably mammalian) expression systems, protein purification and structural biology is very advantageous. You should be able to drive and contribute to research projects and independently develop new research ideas.

Why join us / Benefits

This project is embedded Collaborative Research Center/Transregio CRC/TR 240 – “PLATELETS” funded by the German research foundation (DFG) which provides a research environment and infrastructure that is unique in the platelet field. The project furthermore involves the close interaction with the Structural Biology Department at the Rudolf Virchow Center, as well as long-standing international collaboration partners.

Our department is situated within the Rudolf Virchow Center, an international research center of the University of Würzburg which is part of the Medical Campus of University Hospital Würzburg. The Center provides an inter-disciplinary working environment using state-of-the-art infrastructure. The university offers also a comprehensive services concerning administrative and practical matters, e.g. the Welcome Centre (moving to Würzburg), the International Office, the Family Services as well as the JMU Research Academy (professional support and development) (see www.platelets.eu/career/).

The position is initially limited for two years with the possibility of extension. The salary is commensurate with training and experience according to Collective Agreement for the Public Service of German Federal States TV-L. We particularly encourage female scientists to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.

Send applications to

The position will start on March 1st, 2019 or later. Applications should be sent as one single pdf-document including application letter, curriculum vitae, certificates and 3 references by e-mail until February 15th, 2019 to

The Würzburg Platelet Group / Prof. Bernhard Nieswandt (career@platelets.eu)

 

For further questions please do not hesitate to contact Dr. Irina Pleines (career@platelets.eu).