The Department of Experimental Biomedicine at the

Rudolf Virchow Center/University Hospital Würzburg invites applications for a

Postdoc position (f/m/d)

“Signal transduction in platelet adhesion”

Platelet activation at sites of vascular injury is essential for hemostasis, but in diseased vessels it can also lead to ischemic events, such as heart attack and stroke. Moreover, the interaction of platelets with cells of the immune system (“thrombo-inflammation”) is critically involved in the pathogenesis of inflammatory disease states. The production of platelets by their bone marrow precursor cells, the megakaryocytes, is tightly controlled and disturbances in this process may result in hemorrhagic disorders and vascular defects.

We focus on transgenic mouse models to study the roles of regulatory proteins (receptors, signaling molecules, cytoskeletal components) for platelet production and function in vitro and in vivo. Our research will yield novel insights into the process of platelet biogenesis and the complex functions of platelets in cardiovascular disease. Our long-term goal is to identify novel targets for the development of improved therapies against vascular diseases.

 Activities and responsibilities

The project will focus on the signaling pathways which mediate the hemostatic, thrombotic and thrombo-inflammatory functions of platelets. The applied methods will include cutting edge in vitro and in vivo imaging techniques, platelet functional assays, receptor targeting, molecular biology, biochemistry, mouse genetics and in vivo models of thrombotic/ thrombo-inflammatory disease. As a postdoctoral fellow in our group you will drive your own research project and collaborate closely with other group members, as well as local and international collaboration partners. You will furthermore engage in (co-)supervising PhD students and teaching activities.

You have / Qualification profile

Suitable candidates should hold a doctoral degree in biomedicine, biochemistry, medicine, pharmacy, biochemistry, biology or a related field and have a strong interest in molecular and (vascular) cell biology/immunology, mouse models, different imaging techniques, as well as in vivo disease models. Excellent knowledge of the English language is a prerequisite. Previous experience with genetic mouse models, preferably in the field of vascular biology/immunology, or microscopy is highly advantageous. As a postdoc in our group you should be able to drive and contribute to other research projects and independently develop new research ideas.

Why join us / Benefits

The project is closely associated with the collaborative research center/transregio CRC/TR 240 – “Platelets – Molecular, cellular and systemic functions in health and disease” funded by the German research foundation (DFG) which provides a research environment and infrastructure that is unique in the platelet field. The projects furthermore involve the close interaction with long-standing international collaboration partners.

Our department is situated within the Rudolf Virchow Center, an international research center of the University of Würzburg which is part of the Medical Campus of University Hospital Würzburg. The Center provides an inter-disciplinary working environment using state-of-the-art infrastructure. The university offers also a comprehensive services concerning administrative and practical matters, e.g. the Welcome Centre (moving to Würzburg), the International Office, the Family Services as well as the JMU Research Academy (professional support and development) (see www.platelets.eu/career/).

The salary for this position is commensurate with training and experience according to Collective Agreement for the Public Service of German Federal States TV-L. The position is initially limited for two years with the possibility of extension. We particularly encourage female scientists to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.

Send applications to

The position will start on March 1st, 2019 or later. Applications should be sent as one single pdf-document including application letter, curriculum vitae, certificates and 3 references by e-mail until February 15th, 2019 to

The Würzburg Platelet Group / Prof. Bernhard Nieswandt (career@platelets.eu)

 

For further questions please do not hesitate to contact Dr. Irina Pleines or Dr. David Stegner (career@platelets.eu).