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The Chair of Experimental Biomedicine I,
University Hospital Würzburg and Rudolf-Virchow-Center/University Würzburg, Germany, invites applications for

1 PhD student position (f/m/d)

to investigate immune cell-platelet interactions in ischemic stroke embedded in the DFG-funded Collaborative Research Center CRC/TR 240 “Platelets – Molecular, cellular and systemic functions in health and disease”.

Our interdisciplinary research team investigates the cellular and molecular mechanisms of ischemic stroke, one of the most common causes of physical disability worldwide. Apart from the contribution of platelets to the primary vascular occlusion, they are also significantly involved in the regulation of “thrombo-inflammatory” processes. This means that the interaction between platelets and immune cells is contributing to the resulting brain damage. The underlying mechanisms are, however, largely unknown.

Activities and responsibilities

We are seeking a highly motivated PhD student to work on a project that combines in vitro and in vivo models of ischemic stroke will be combined with advanced imaging techniques to decipher the molecular interplay of platelets and immune cells in the context of ischemic stroke. Besides intra-vital two-photon microscopy and light-sheet fluorescence microscopy, genetically modified mice, and functional cellular assays as well as biochemical and molecular biology approaches will be part of the PhD project. The project aims at providing new insights into the molecular basis of ischemic brain infarction.

Qualification profile

Suitable candidates should hold a Master’s degree or equivalent in a life sciences subject with a strong interest in molecular and (vascular) cell biology/immunology, mouse models and different imaging techniques. Excellent lab skills and good knowledge of the English language are a prerequisite. Previous experience with in vivo work and/or advanced imaging techniques is highly advantageous.

Benefits

We offer an international and excellent scientific environment that is embedded in the framework of a German wide research consortium on platelets. Its infrastructure is unique in the platelet research field and offers the opportunity to collaborate with national and international basic and translational research groups. The department involves several research labs consisting of post-doctoral scientists, PhD students, master students and research assistants and comes along with a pleasant working atmosphere.

As a PhD student you will have the opportunity to become part of the international ‘Graduate School of Life Sciences’ (GSLS). The university furthermore offers comprehensive services concerning administrative and practical matters, e.g. the Welcome Centre (moving to Würzburg) and the International Office.

The salary for this temporary position is commensurate with training and experience according to Collective Agreement for the Public Service of German Federal States TV-L (E13 (65%). We particularly encourage female scientists to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.

Send applications to

The position will start on March 1st, 2022 or later. Applications should be sent as a single pdf-document including application letter, curriculum vitae, certificates including contact details of two references by e-mail until January 31st, 2022 to Prof. Dr. David Stegner (career@platelets.eu).

For further questions, please do not hesitate to contact Prof. Dr. David Stegner (stegner@virchow.uni-wuerzburg.de).