Programme
- 17th of September
14:30 – 20:00 Opening Session
- 14:30 – 16:00 Meeting registration with coffee
- 16:00 – 16:30 Welcome and Opening Remarks
With high-class musical accompaniment by violin virtuoso Florian Meierott,
performing together with Henri Meierott (violine) and Katrin Koeth (piano).
“Würzburg – in the heart of Europe” – part 1
Music from Belgium/Italy, Austria, France and Germany
- Joseph-Hector Fiocco (1703–1741) - “Allegro”
- Fritz Kreisler (1875–1962) - “Prelude and Allegro”
Florian Meierott was born in Würzburg in 1968 and began playing the violin at the age of four. Raised in a highly musical family, he began performing concerts at an early age.
After studying (graduating “summa cum laude”) with his teachers Max Speermann, Ulf Hoelscher, Wilhelm Melcher, the Melosquartett and master classes with Zachar Bron and Ruggieri Ricci, among others, he was awarded numerous prizes.
Concerts have taken and continue to take him regularly as a soloist from Japan, Korea, America, South Africa and all over Europe to the big stages such as the Mozarteum Salzburg, Berlin Philharmonie and Schauspielhaus, the Schleswig-Holstein Festival, the “Palais des beaux arts” in Brussels and later London, Rome, Barcelona, Edinburgh and Paris.
Since 2015 he has been one of the few violinists in the world to play all of JS Bach’s sonatas and partitas by heart in a concert, including in the Berlin Philharmonic, the Munich Gasteig and the Laeiszhalle in Hamburg.
Meierott plays an Italian violin from around 1780 and a bow by Charles Peccatte, Paris, from around 1910.
- 16:30 – 17:00 Keynote Lecture 1 - Replicating Bone Marrow Niche Architecture to Support Megakaryocyte Function and Platelet Production | Alessandra Balduini, Pavia, Italy and Boston, USA
- 17:00 – 17:30 Keynote Lecture 2 - Platelet adhesion: new insights into integrin affinity regulation | Wolfgang Bergmeier, Chapel Hill, USA
Musical accompaniment – part 2
- Johann Sebastian Bach (1685–1750) - from the Concerto for 2 Violins, BWV 1043
- Camille Saint-Saëns (1835–1921) - From the “Rondo capriccioso”
- 17:40 – 20:00 Drinks reception in the foyer of the Rudolf Virchow Center
- 18th of September
8:45 – 10:30 Session 1
- 08:45 – 09:00 Welcome and short presentation of next EUPLAN meeting
- 09:00 – 09:30 Keynote Lecture 3 - Defining and harnessing the MK/platelet checkpoint | Yotis Senis, Marseille, France
- 09:30 – 09:45 OC1 - ATP11A and ATP11C are the phosphatidylserine flippases at the plasma membrane of in vitro human megakaryocytes – Ruby Baxter, Cambridge, UK
- 09:45 – 10:00 OC2 - Altered platelet and megakaryocyte phenotypes in a mouse model of liver fibrosis – Martina Casari, Mainz, Germany
- 10:00 – 10:15 OC3 - The RNA-aptamer Apta-1 induces antithrombotic but not anticoagulant activity – Magnus Grenegard, Örebro, Sweden
- 10:15 – 10:30 Poster preview
- 10:30 – 11:00 Coffee break
- 11:00 – 11:30 Keynote Lecture 4 - Mitochondrial dynamics in platelets and megakaryocytes | Harriet Allan, London, UK
- 11:30 – 11:45OC4 - Mitochondrial Calcium Uniporter Regulates Megakaryopoiesis and Functional Platelet Production – Christian Di Buduo, Pavia, Italy
- 11:45 – 12:00 OC5 - A novel β1-tubulin mutation associated with secretion-dependent platelet hyperactivity and prothrombotic risk via GPVI and CLEC-2 engagement – Toscane Viellard, Paris, France
- 12:00 – 12:15 OC6 - Platelet PN-1 regulates clot structure and retraction – Yacine Boulaftali, Paris, France
- 12:15 – 12:30 OC7 - Platelet-Derived Integrin and Tetraspanin-Enriched Tethers (PITTs): A Novel Mechanism of Integrin αIIbβ3 Regulation and Intercellular Communication – Ceylan Onursal, Würzburg, Germany
- 12:30 – 14:30 Lunch and posters (odd numbers; poster session starts at 13:00)
- 14:30 – 15:00 Keynote Lecture 5 - Platelet subpopulations, immunothrombosis and thrombo-inflammation – how can we determine platelet function(s) at the interface of hemostasis and inflammation | Harald Schulze, Würzburg, Germany
- 15:00 – 15:15 OC08 - Characterization of platelet activating histone/anti-histone immune complexes as a new cause of immunothrombosis – Stefan Handtke, Greifswald, Germany
- 15:15 – 15:30OC09 - FcγRIIA-mediated procoagulant platelets are important drivers of immunothrombosis in APS – Jan Zlamal, Tübingen, Germany
- 15:30 – 15:45 OC10 - The tyrosine kinase Pyk2 regulates platelet activation and early inflammation in a model of low grade endotoxemia – Ilaria Canobbio, Pavia, Italy
- 15:45 – 16:00 OC11 - Uncovering thromboflammation as a pathogenic mechanism in Hutchinson-Gilford progeria syndrome (HGPS): Implications for GPVI-Targeted Therapy – Sonia Aguila, Murcia, Spain
- 16:00 – 17:30 Coffee and posters (even numbers)
19:30 Social event
CULINARY WINE TASTING in the “Residenzweinkeller”
THE HARMONY OF FOOD AND WINE
– AN ENJOYABLE EXPERIENCE OF A SPECIAL KIND.
• 1 glass of sparkling wine as a welcome drink’
• Short walk through the historic cellar vault
• Splendidly illuminated wine cellar
• 6 selected wines corresponding to the 3-course menu
• Mineral water + bread
• Expert wine moderation
With its extensive courtyard garden, the bright and rich architecture of Neumann and the breathtaking frescoes of the Venetian Giovanni Battista Tiepolo, the Würzburger Residenz is one of the most important Baroque palace complexes in Europe and was added to the UNESCO World Heritage List in 1981.
In 1719, Balthasar Neumann, the master builder from Eger, was commissioned to build a new residence in Würzburg and given the task of including, above all, an “excellent wine cellar“.
Visitors who wander through the atmospherically illuminated corridors and vaults of the Residenzweinkeller (wine cellar) today will discover one of the most beautiful wine cellars in the world.
- 19th of September
- 09:00 – 09:30 Keynote Lecture 6 - Cell motility in megakaryocytes and platelets | Florian Gärtner, Munich, Germany
- 09:30 – 09:45 OC12 - Surficial ligand anisotropy differentially affects megakaryocyte protrusion formation – Dmitri Sisario, Würzburg, Germany
- 09:45 – 10:00 OC13 - Megakaryopoiesis disorder in sickle cell disease – Jonatane Andrieu, Marseille, France
- 10:00 – 10:15 OC14 - Granulopoiesis and thrombopoiesis aberrantly synergize in cancer to promote tumor progression – Christoph Reichel, Munich, Germany
- 10:15 – 10:30 OC15 - Therapeutic Candidate for treating thrombocytopenia in Wiskott-Aldrich Syndrome – Rhaissa Vieria, Stockholm, Sweden
- 10:30 – 10:45 Photo
- 10:45 – 11:15 Coffee break and posters
11:15 – 13:05 Session 5
- 11:15 – 11:45 Keynote Lecture 7 - Unlocking platelet biology using patient-based omics studies | Kathleen Freson, Leuven, Belgium
- 11:45 – 12:00 OC16 - Unraveling the transcriptomic profile of RUNX-1-related thrombocytopenia in human platelets – Ana Marin-Quilez, Murcia, Spain
- 12:00 – 12:15 OC17 - Identification of a novel GPVI-inhibitor lead compound ready to progress to preclinical assays to explore its antithrombotic potential – Sofia Perez-Espinanzo, Santiago de Compostela, Spain
- 12:15 – 12:30 OC18 - Platelet-specific SLFN14 deletion causes macrothrombocytopenia and reduced thrombin-mediated signaling through dysregulated gene expression in megakaryocytes and platelets – Xenia Sawkulycz, Birmingham, UK
- 12:30 – 12:35 voting for best talk
- 12:35 – 13:05 Keynote Lecture 8 - Platelet Dysfunction: Understanding and Detecting Defects | Alice Assinger, Vienna, Austria
- 13:05 – 13:20 Awards giving
- 13:20 – 13:30 Closing remarks
- 13:30 Lunch boxes
- 14:00 End