The program of Thrombo-Inflame is designed to advance our understanding of thrombo-inflammation, with a particular focus on the complex biology of platelets and megakaryocytes. 

The work programme is organized into eight unique yet interrelated projects, each lead by a tandem of two project leaders with complementary expertise. This arrangement aims to stimulate collaboration and foster innovation across all projects. Each project will be assigned two dedicated PhD candidates, ensuring a targeted and multi-disciplinary approach to exploring the diverse aspects of thrombo-inflammation. The sole exception is project P08, which will be carried out by one PhD candidate.

Our projects leverage a wide array of innovative techniques and models to dissect the mechanisms of thrombo-inflammation. These include the use of a number of genetically-modified mouse lines, several in vivo disease models (ischemic stroke, sepsis, lung inflammation, inflammaging), state-of-the-art imaging technologies, and advanced image analysis pipelines for comprehensive spatial and temporal resolution. Additionally, the program employs a variety of in vitro experimental models, such as microfluidic thrombus formation assays, and cutting-edge methodologies in single-cell RNA sequencing.

This comprehensive approach not only aims to identify novel therapeutic targets but also fosters the development of a diversified skill set among our PhD candidates. By exploiting the synergies between our collaborative groups and their specialized methods, RTG 3048 aims to uncover the intricate nature of thrombo-inflammation, potentially leading to groundbreaking advancements in the treatment of these critical conditions.