The new Research Training Group RTG 3190 – Thrombo-Inflame: Dissecting and Modulating Megakaryocyte/Platelet-Driven Thrombo-Inflammation addresses a central disease mechanism: thrombo-inflammation, the intricate interplay between platelets, the coagulation system and the body’s inflammatory processes. While thrombosis and inflammation were long considered separate, experimental and clinical evidence now shows that they are closely intertwined in conditions such as stroke, infections, autoimmune diseases and severe injuries. Despite its clinical importance, this interplay remains insufficiently understood.