Understanding megakaryocyte maturation
We are dedicated to exploring the development of megakaryocytes, the remarkable cells that give rise to platelets. Our mission is centred on deciphering the intricate molecular processes involved in the differentiation, maturation, signalling, and platelet production of megakaryocytes. Understanding these processes is crucial for addressing clinical conditions such as thrombocytopenia (low platelet count) and myelofibrosis (scarring of the bone marrow), which can arise from dysfunctional megakaryocytes. As a novel addition to the renowned Würzburg Platelet Group, our work brings fresh perspectives and innovative approaches to advance the science of megakaryocytes and platelets.
Significance
Platelets, the smallest circulating blood cells, are crucial for preventing blood loss during injuries or surgeries. Despite their importance, both the process of platelet formation from megakaryocytes and the factors regulating the development of these precursor cells remain poorly understood. This knowledge gap is critical, as the demand for platelet transfusions — essential for patients at high risk of bleeding or undergoing cancer treatment — is expected to lead to significant shortages of platelet concentrates in the near future.
Objectives
Our primary aim is to deepen our understanding of megakaryocyte maturation within the bone marrow. We believe this is key for developing innovative strategies that could either enhance platelet production in laboratory settings or lead to novel therapies aimed at increasing platelet counts in individuals requiring medical intervention. We are committed to addressing this question of considerable scientific and clinical importance.
Funding
We are funded by the Emmy Noether Programme of the German Research Foundation (DFG).
