Publications

2022

David Stegner, Vanessa Göb, Viola Krenzlin, Sarah Beck, Katherina Hemmen, Michael K. Schuhmann, Barbara F. Schörg, Christian Hackenbroch, Frauke May, Philipp Burkard, Jürgen Pinnecker, Alma Zernecke, Peter Rosenberger, Andreas Greinacher, Bernd J. Pichler, Katrin G. Heinze, Guido Stoll, and Bernhard Nieswandt: Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation. Nature Cardiovascular Research. 2022 Feb 10.
doi: 10.1038/s44161-021-00017-1.

Becker IC, Nagy Z, Manukjan G, Haffner-Luntzer M, Englert M, Heib T, Vögtle T, Gross C, Bharti R, Dietrich S, Mott K, Heck J, Stegmaier S, Baranowsky A, Schinke T, Schlegel N, Heckel T, Stegner D, Pleines I, Ignatius A, Schulze H, Nieswandt B. G6b-B regulates an essential step in megakaryocyte maturation. Blood Adv. 2022 Feb 8: bloodadvances.2021006151.
doi: 10.1182/bloodadvances.2021006151. Online ahead of print. PMID: 35134123.

Heil HS, Aigner M, Maier S, Gupta P, Evers LMC, Göb V, Kusch C, Meub M, Nieswandt B, Stegner D, Heinze KG. Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy. Platelets. 2022 Feb 2:1-10.
doi: 10.1080/09537104.2021.2023735. Online ahead of print. PMID: 35109754.

Sachs L, Wesche J, Lenkeit L, Greinacher A, Bender M, Otto O, Palankar R. Ex vivo anticoagulants affect human blood platelet biomechanics with implications for high-throughput functional mechanophenotyping. Commun Biol. 2022 Jan 21;5(1):86.
doi: 10.1038/s42003-021-02982-6. PMID: 35064207.

Bennett C, Lawrence M, Guerrero JA, Stritt S, Waller AK, Yan Y, Mifsud RW, Ballester-Beltran J, Baig AA, Mueller A, Mayer L, Warland J, Penkett CJ, Akbari P, Moreau T, Evans AL, Mookerjee S, Hoffman GJ, Saeb-Parsy K, Adams D, Couzens AL, Bender M, Erber W, Nieswandt B, Read RJ, Ghevaert C. CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythaemia. Blood. 2022 Jan 20: blood.2021013113.
doi: 10.1182/blood.2021013113. Online ahead of print. PMID: 35051265.

Schanbacher C, Bieber M, Reinders Y, Cherpokova D, Teichert C, Nieswandt B, Sickmann A, Kleinschnitz C, Langhauser F, Lorenz K. ERK1/2 Activity Is Critical for the Outcome of Ischemic Stroke. Int J Mol Sci. 2022 Jan 9 ;23(2):706.
doi: 10.3390/ijms23020706. PMID: 35054890.

Perrella G, Montague SJ, Brown HC, Garcia Quintanilla L, Slater A, Stegner D, Thomas M, Heemskerk JWM, Watson SP. Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear. Int J Mol Sci. 2022 Jan 1;23(1):493.
doi: 10.3390/ijms23010493. PMID: 35008919.

Rosa A, Butt E, Hopper CP, Loroch S, Bender M, Schulze H, Sickmann A, Vorlova S, Seizer P, Heinzmann, Zernecke A. Cyclophilin A is not acetylated at Lysine-82 and Lysine-125 in resting and stimulated platelets. Int J Mol Sciences 2022; Manuscript accepted for publication.

2021

Navarro S, Stegner D, Nieswandt B, Heemskerk JWM, Kuijpers MJE. Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation. Int J Mol Sci. 2021 Dec 29;23(1):358.
doi: 10.3390/ijms23010358. PMID: 35008781.

Seyhan M, Ungethüm K, Schuhmann MK, Mackenrodt D, Rücker V, Montellano FA, Wiedmann S, Rath D, Geisler T, Nieswandt B, Kraft P, Kleinschnitz C, Heuschmann PU.Feasibility of platelet marker analysis in ischemic stroke patients and their association with one-year outcome. A pilot project within a subsample of the Stroke Induced Cardiac Failure in Mice and Men (SICFAIL) cohort study. Platelets. 2021 Dec 7:1-9.
doi: 10.1080/09537104.2021.2002834. Online ahead of print. PMID: 34875957.

Göb V, Voll MG, Zimmermann L, Hemmen K, Stoll G, Nieswandt B, Schuhmann MK, Heinze KG, Stegner D. Infarct growth precedes cerebral thrombosis following experimental stroke in mice. Sci Rep. 2021 Nov 24;11(1):22887.
doi: 10.1038/s41598-021-02360-6. PMID: 34819574.

Beck S, Stegner D, Loroch S, Baig AA, Göb V, Schumbrutzki C, Eilers E, Sickmann A, May F, Nolte MW, Panousis C, Nieswandt B. Generation of a humanized FXII knock-in mouse-A powerful model system to test novel anti-thrombotic agents. J Thromb Haemost. 2021 Nov;19(11):2835-2840.
doi: 10.1111/jth.15488. Epub 2021 Aug 19. PMID: 34363738.

Italiano JE, Bender M, Merrill-Skoloff G, Ghevaert C, Nieswandt B, Flaumenhaft R. Microvesicles, but not platelets, bud off from mouse bone marrow megakaryocytes. Blood. 2021 Nov 18;138(20):1998-2001.
doi: 10.1182/blood.2021012496. PMID: 34324659. Letter to blood

Bieber M, Schuhmann MK, Kollikowski AM, Stegner D, Nieswandt B, Pham M, Stoll G. Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice. Exp Neurol. 2021 Oct; 344:113804.
doi: 10.1016/j.expneurol.2021.113804. Epub 2021 Jul 6. PMID: 34237320.

Vogelsang A, Eichler S, Huntemann N, Masanneck L, Böhnlein H, Schüngel L, Willison A, Loser K, Nieswandt B, Kehrel BE, Zarbock A, Göbel K, Meuth SG. Platelet Inhibition by Low-Dose Acetylsalicylic Acid Reduces Neuroinflammation in an Animal Model of Multiple Sclerosis. Int J Mol Sci. 2021 Sep 14;22(18):9915.
doi: 10.3390/ijms22189915. PMID: 34576080.

Kollikowski AM, Pham M, März AG, Papp L, Nieswandt B, Stoll G, Schuhmann MK. Platelet Activation and Chemokine Release Are Related to Local Neutrophil-Dominant Inflammation During Hyperacute Human Stroke. Transl Stroke Res. 2021 Aug 28.
doi: 10.1007/s12975-021-00938-w. Online ahead of print. PMID: 34455571.

Manke MC, Geue S, Coman C, Peng B, Kollotzek F, Münzer P, Walker B, Huber SM, Rath D, Sickmann A, Stegner D, Duerschmied D, Lang F, Nieswandt B, Gawaz M, Ahrends R, Borst O. ANXA7 Regulates Platelet Lipid Metabolism and Ca2+ Release in Arterial Thrombosis. Circ Res. 2021 Aug 6;129(4):494-507.
doi: 10.1161/CIRCRESAHA.121.319207. Epub 2021 Jun 28. PMID: 34176316.

Scheller I, Beck S, Göb V, Gross C, Neagoe RAI, Aurbach K, Bender M, Stegner D, Nagy Z, Nieswandt B. Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets. Haematologica. 2021 Aug 5.
doi: 10.3324/haematol.2021.278537. Online ahead of print. PMID: 34348450.

Quach ME, Chen W, Wang Y, Deckmyn H, Lanza F, Nieswandt B, Li R. Differential regulation of the platelet GPIb-IX complex by anti-GPIbβ antibodies. J Thromb Haemost. 2021 Aug;19(8):2044-2055.
doi: 10.1111/jth.15359. Epub 2021 May 20. PMID: 33915031.

Jadoui S, Le Chapelain O, Ollivier V, Mostefa-Kara A, Di Meglio L, Dupont S, Gros A, Nomenjanahary MS, Desilles JP, Mazighi M, Nieswandt B, Loyau S, Jandrot-Perrus M, Mangin PH, Ho-Tin-Noé B. Glenzocimab does not impact glycoprotein VI-dependent inflammatory haemostasis. Haematologica. 2021 Jul 1;106(7):2000-2003.
doi: 10.3324/haematol.2020.270439. PMID: 33375772.

Weiss LJ, Manukjan G, Pflug A, Winter N, Weigel M, Nagler N, Kredel M, Lâm TT, Nieswandt B, Weismann D, Schulze H. Acquired platelet GPVI receptor dysfunction in critically ill patients with sepsis. Blood. 2021 Jun 3;137(22):3105-3115.
doi: 10.1182/blood.2020009774. PMID: 33827131.

Heib T, Hermanns HM, Manukjan G, Englert M, Kusch C, Becker IC, Gerber A, Wackerbarth LM, Burkard P, Dandekar T, Balkenhol J, Jahn D, Beck S, Meub M, Dütting S, Stigloher C, Sauer M, Cherpokova D, Schulze H, Brakebusch C, Nieswandt B, Nagy Z, Pleines I. RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes. Cell Rep. 2021 May 11;35(6):109102.
doi: 10.1016/j.celrep.2021.109102. PMID: 33979620.

Bornert A, Boscher J, Pertuy F, Eckly A, Stegner D, Strassel C, Gachet C, Lanza F, Léon C. Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation. Haematologica. 2021 May 1;106(5):1368-1380.
doi: 10.3324/haematol.2019.239111. PMID: 32327502. 

Wagner N, Mott K, Upcin B, Stegner D, Schulze H, Ergün S. CXCL12-Abundant Reticular (CAR) Cells Direct Megakaryocyte Protrusions across the Bone Marrow Sinusoid Wall. Cells. 2021 Mar 24;10(4):722.
doi: 10.3390/cells10040722. PMID: 33804965.

Haining EJ, Lowe KL, Wichaiyo S, Kataru RP, Nagy Z, Kavanagh DP, Lax S, Di Y, Nieswandt B, Ho-Tin-Noé B, Mehrara BJ, Senis YA, Rayes J, Watson SP. Lymphatic blood filling in CLEC-2-deficient mouse models. Platelets. 2021 Apr 3;32(3):352-367.
doi: 10.1080/09537104.2020.1734784. Epub 2020 Mar 4. PMID: 32129691.

Janus-Bell E, Ahmed MU, Receveur N, Mouriaux C, Nieswandt B, Gardiner EE, Gachet C, Jandrot-Perrus M, Mangin PH. Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability. Thromb Haemost. 2021 Apr;121(4):543-546.
doi: 10.1055/s-0040-1718737. Epub 2020 Oct 29. PMID: 33124026.

Stegner D, Nieswandt B. XPoRting (poly)phosphates limits thrombosis. Blood. 2021 Mar 11;137(10):1278-1280.
doi: 10.1182/blood.2020008973. PMID: 33704397.

Stahnke S, Döring H, Kusch C, de Gorter DJJ, Dütting S, Guledani A, Pleines I, Schnoor M, Sixt M, Geffers R, Rohde M, Müsken M, Kage F, Steffen A, Faix J, Nieswandt B, Rottner K, Stradal TEB. Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion. Curr Biol. 2021 May 24;31(10):2051-2064.e8.
doi: 10.1016/j.cub.2021.02.043. Epub 2021 Mar 11. PMID: 33711252.

Clark JC, Neagoe RAI, Zuidscherwoude M, Kavanagh DM, Slater A, Martin EM, Soave M, Stegner D, Nieswandt B, Poulter NS, Hummert J, Herten DP, Tomlinson MG, Hill SJ, Watson SP. Evidence that GPVI is Expressed as a Mixture of Monomers and Dimers, and that the D2 Domain is not Essential for GPVI Activation. Thromb Haemost. 2021 Feb 26. doi: 10.1055/a-1401-5014. Epub 2021 Feb 26. PMID: 33638140.

Althaus K, Marini I, Zlamal J, Pelzl L, Singh A, Häberle H, Mehrländer M, Hammer S, Schulze H, Bitzer M, Malek N, Rath D, Bösmüller H, Nieswandt B, Gawaz M, Bakchoul T, Rosenberger P. Antibody-induced procoagulant platelets in severe COVID-19 infection. Blood. 2021 Feb 25;137(8):1061-1071.
doi: 10.1182/blood.2020008762. PMID: 33512415.

Gadi I, Fatima S, Elwakiel A, Nazir S, Mohanad Al-Dabet M, Rana R, Bock F, Manoharan J, Gupta D, Biemann R, Nieswandt B, Braun-Dullaeus R, Besler C, Scholz M, Geffers R, Griffin JH, Esmon CT, Kohli S, Isermann B, Shahzad K. Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently. Circ Res. 2021 Feb 19;128(4):513-529.
doi: 10.1161/CIRCRESAHA.120.317219. Epub 2020 Dec 23. PMID: 33353373.

Schuhmann MK, Bieber M, Franke M, Kollikowski AM, Stegner D, Heinze KG, Nieswandt B, Pham M, Stoll G. Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice. J Neuroinflammation. 2021 Feb 18;18(1):46.
doi: 10.1186/s12974-021-02095-1. PMID: 33602266.

Bender M, Palankar R. Platelet Shape Changes during Thrombus Formation: Role of Actin-Based Protrusions. Hamostaseologie. 2021 Feb;41(1):14-21.
doi: 10.1055/a-1325-0993. Epub 2021 Feb 15. PMID: 33588449.

Megy K, Downes K, Morel-Kopp M-C, Bastida JM, Brooks S, Bury L, Leinoe E, Gomez K, Morgan NV, Othman M, Ouwehand WH, Perez Botero J, Rivera J, Schulze H, Trégouët D-A, Freson K. GoldVariants, a resource for sharing rare genetic variants detected in bleeding, thrombotic, and platelet disorders: Communication from the ISTH SSC Subcommittee on Genomics in Thrombosis and Hemostasis. J Thromb Haemost. 2021; 19(10):2612-2617.
doi: 10.1111/jth.15459. Epub 2021 Aug 5. PMID: 34355501.

Laukner A, Truchet L, Manukjan G, Schulze H, Langbein-Detsch I, Müller E, Leeb T, Kehl A. Effects of Cocoa Genotypes on Coat Color, Platelets and Coagulation Parameters in French Bulldogs. Genes 2021; 12(7):1092.
doi: 10.3390/genes12071092.

Herrmann J, Notz Q, Schlesinger T, Stumpner J, Kredel M, Sitter M, Schmid B, Kranke P, Schulze H, Meybohm P, Lotz C. Point of care diagnostic of hypercoagulability and platelet function in COVID-19 induced acute respiratory distress syndrome: a retrospective observational study.  Thrombosis Journal 2021; 19:39.
doi.org/10.1186/s12959-021-00293-8. PMID: 34078393.

Cullmann K, Jahn M, Spindler M, Schenk F, Manukjan G, Mucci A, Steinemann D, Boller K, Schulze H, Bender M, Moritz T, Modlich U. Generation of megakaryocytes from murine induced pluripotent stem cells by the inducible overexpression of supporting factors. rpth 2021; 5:111–124.

2020

Pfeil EM, Brands J, Merten N, Vögtle T, Vescovo M, Rick U, Albrecht IM, Heycke N, Kawakami K, Ono Y, Ngako Kadji FM, Hiratsuka S, Aoki J, Häberlein F, Matthey M, Garg J, Hennen S, Jobin ML, Seier K, Calebiro D, Pfeifer A, Heinemann A, Wenzel D, König GM, Nieswandt B, Fleischmann BK, Inoue A, Simon K, Kostenis E. Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs. Mol Cell. 2020 Dec 17;80(6):940-954.e6.
doi: 10.1016/j.molcel.2020.10.027. Epub 2020 Nov 16. PMID: 33202251.

Nicolai L, Schiefelbein K, Lipsky S, Leunig A, Hoffknecht M, Pekayvaz K, Raude B, Marx C, Ehrlich A, Pircher J, Zhang Z, Saleh I, Marel AK, Löf A, Petzold T, Lorenz M, Stark K, Pick R, Rosenberger G, Weckbach L, Uhl B, Xia S, Reichel CA, Walzog B, Schulz C, Zheden V, Bender M, Li R, Massberg S, Gaertner F. Vascular surveillance by haptotactic blood platelets in inflammation and infection. Nat Commun. 2020 Nov 13;11(1):5778.
doi: 10.1038/s41467-020-19515-0. PMID: 33188196.

Volz J, Kusch C, Beck S, Popp M, Vögtle T, Meub M, Scheller I, Heil HS, Preu J, Schuhmann MK, Hemmen K, Premsler T, Sickmann A, Heinze KG, Stegner D, Stoll G, Braun A, Sauer M, Nieswandt B. BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation. J Clin Invest. 2020 Nov 2;130(11):6064-6079.
doi: 10.1172/JCI136457. PMID: 32750041.

Chen C, Rawat D, Samikannu B, Bender M, Preissner KT, Linn T.
Platelet Glycoprotein VI dependent Thrombus Stabilization is Essential for the Intraportal Engraftment of Pancreatic Islets. Am J Transplant. 2020 Oct 25.
doi: 10.1111/ajt.16375. Epub 2020 Nov 19. PMID: 33099857.

Gupta S, Konradt C, Corken A, Ware J, Nieswandt B, Di Paola J, Yu M, Wang D, Nieman MT, Whiteheart SW, Brass LFHemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation. Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A). 2020 Sep 29;117(39):24316-24325.
doi: 10.1073/pnas.2007642117. Epub 2020 Sep 14. PMID: 32929010.

Schuhmann MK, Stoll G, Bieber M, Vögtle T, Hofmann S, Klaus V, Kraft P, Seyhan M, Kollikowski AM, Papp L, Heuschmann PU, Pham M, Nieswandt B, Stegner D. CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke. Circ Res. 2020 Sep 25;127(8):1023-1035.
doi: 10.1161/CIRCRESAHA.120.316655. Epub 2020 Jul 30. PMID: 32762491.

Rommel M, Milde C, Eberle R, Schulze H, Modlich U. Endothelial-platelet interactions in influenza-induced pneumonia: A potential therapeutic target.  Anatomia, Histologia, Embryologia 2020 Sep;49(5):606-619.
doi: 10.1111/ahe.12521. Epub 2019 Dec 2. PMID: 31793053

Schmitt MER, Lutz J, Haase P, Bösl MR, Wienands J, Engels N, Voehringer D. The B-cell antigen receptor of IgE-switched plasma cells regulates memory IgE responses. J Allergy Clin Immunol. 2020 Sep;146(3):642-651.e5.
doi: 10.1016/j.jaci.2020.02.015. Epub 2020 Feb 28. PMID: 32113980.

Vögtle T, Baig AA, Volz J, Duchow TB, Pleines I, Dütting S, Nitschke L, Watson SP, Nieswandt B. Critical redundant functions of the adapters Grb2 and Gads in platelet (hem)ITAM signaling in mice. Platelets. 2020 Aug 17;31(6):801-811.
doi: 10.1080/09537104.2019.1709633. Epub 2020 Jan 16. PMID: 31948362.

Bächer C, Bender M, Gekle S. Flow-accelerated platelet biogenesis is due to an elasto-hydrodynamic instability. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):18969-18976.
doi: 10.1073/pnas.2002985117. Epub 2020 Jul 27. PMID: 32719144.

Ariens R, Becattini C, Bender M, Bergmeier W, Castoldi E, Devreese K, Ellis M, Gailani D, Ignjatovic V, James PD, Kerrigan S, Lambert M, Lee LH, Levi M, Maugeri N, Meijers J, Melero-Martin J, Michelson AD, Mingozzi F, Neeves K, Ni H, Olsson AK, Prohászka Z, Ranson M, Riva N, Senis Y, van Ommen CH, Vaughan DE, Weisel J. Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress. Res Pract Thromb Haemost. 2020 Jul 12;4(5):680-713.

Bertović I, Kurelić R, Milošević I, Bender M, Krauss M, Haucke V, Jurak Begonja A. Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes. J Thromb Haemost. 2020 Jul;18(7):1756-1772.
doi: 10.1111/jth.14764. Epub 2020 Mar 17. PMID: 32056354.

Scheller I, Stritt S, Beck S, Peng B, Pleines I, Heinze KG, Braun A, Otto O, Ahrends R, Sickmann A, Bender M, Nieswandt B. Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets. Haematologica. 2020 Jun;105(6):1667-1676.
doi: 10.3324/haematol.2019.225516. Epub 2019 Oct 3. PMID: 31582545.

Salzmann M, Schrottmaier WC, Kral-Pointner JB, Mussbacher M, Volz J, Hoesel B, Moser B, Bleichert S, Morava S, Nieswandt B, Schmid JA, Assinger A. Haematologica. Genetic platelet depletion is superior in platelet transfusion compared to current models. 2020 Jun;105(6):1738-1749.
doi: 10.3324/haematol.2019.222448. Epub 2019 Sep 19. PMID: 31537686.
Korrektur (Fig. 5):
Salzmann M, Schrottmaier WC, Kral-Pointner JB, Mussbacher M, Volz J, Hoesel B, Moser B, Bleichert S, Morava S, Nieswandt B, Schmid JA, Assinger A. Genetic platelet depletion is superior in platelet transfusion compared to current models. Haematologica. 2020 Nov 1;105(11):2698.
doi: 10.3324/haematol.2020.266072. PMID: 33131266.

Burkard P, Vögtle T, Nieswandt B. Platelets in Thrombo-Inflammation: Concepts, Mechanisms, and Therapeutic Strategies for Ischemic Stroke. Hamostaseologie. 2020 Jun;40(2):153-164.
doi: 10.1055/a-1151-9519. Epub 2020 May 26. PMID: 32455457.

Becker IC, Scheller I, Wackerbarth LM, Beck S, Heib T, Aurbach K, Manukjan G, Gross C, Spindler M, Nagy Z, Witke W, Lappalainen P, Bender M, Schulze H, Pleines I, Nieswandt B. Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1. Blood Adv. 2020 May 26;4(10):2124-2134.
doi: 10.1182/bloodadvances.2019001303. PMID: 32407474.

Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, Burkard P, Shityakov S, Schonhart C, Stegner D, Remer K, Nurden P, Nurden AT, Dandekar T, Nehez L, Dank M, Braun A, Mezzano D, Abrams SI, Nieswandt B. Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3. Blood. 2020 Apr 2;135(14):1146-1160.
doi: 10.1182/blood.2019002649. PMID: 32040544.

Green HLH, Zuidscherwoude M, Alenazy F, Smith CW, Bender M, Thomas SG. SMIFH2 inhibition of platelets demonstrates a critical role for formin proteins in platelet cytoskeletal dynamics. J Thromb Haemost. 2020 Apr;18(4):955-967.
doi: 10.1111/jth.14735. Epub 2020 Feb 17. PMID: 31930764.

Gorelashvili MG, Angay O, Hemmen K, Klaus V, Stegner D, Heinze KG. Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics. Haematologica. 2020 Apr;105(4):895-904.
doi: 10.3324/haematol.2018.202010. Epub 2019 Jun 27. PMID: 31248970.

Köhler D, Granja T, Volz J, Koeppen M, Langer HF, Hansmann G, Legchenko E, Geisler T, Bakchoul T, Eggstein C, Häberle HA, Nieswandt B, Rosenberger P. Nat Commun. 2020 Mar 11;11(1):1315. Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb.
doi: 10.1038/s41467-020-14958-x. PMID: 32161256.

Scheller I, Nieswandt B. Thromb Haemost. 2020 Mar;120(3):372. Novel Approaches to Unravel Risk Factors and Mechanisms of Venous Thrombosis.
doi: 10.1055/s-0040-1702232. Epub 2020 Mar 5. PMID: 32135564.

Kollikowski AM, Schuhmann MK, Nieswandt B, Müllges W, Stoll G, Pham M. Local Leukocyte Invasion during Hyperacute Human Ischemic Stroke. Ann Neurol. 2020 Mar;87(3):466-479.
doi: 10.1002/ana.25665. Epub 2020 Jan 16. PMID: 31899551.

Manukjan G, Wiegering VA, Reindl T, Strauß G, Klopocki E, Schulze H, Andres O. Novel variants in FERMT3 and RASGRP2-Genetic linkage in Glanzmann-like bleeding disorders. PEDIATR BLOOD CANCER. 2020 Feb;67(2):e28078.
doi: 10.1002/pbc.28078. Epub 2019 Nov 14. PMID: 31724816

Dunster JL, Unsworth AJ, Bye AP, Haining EJ, Sowa MA, Di Y, Sage T, Pallini C, Pike JA, Hardy AT, Nieswandt B, García Á, Watson SP, Poulter NS, Gibbins JM, Pollitt AY. Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. J Thromb Haemost. 2020 Feb;18(2):485-496.
doi: 10.1111/jth.14673. Epub 2019 Dec 6. PMID: 31680418.

2019

Schurr Y, Sperr A, Volz J, Beck S, Reil L, Kusch C, Eiring P, Bryson S, Sauer M, Nieswandt B, Machesky L, Bender M. Platelet lamellipodium formation is not required for thrombus formation and stability. Blood. 2019 Dec 19;134(25):2318-2329.
doi: 10.1182/blood.2019002105. PMID: 31697813.

Stoll G, Nieswandt B. Thrombo-inflammation in acute ischaemic stroke – implications for treatment. Nat Rev Neurol. 2019 Jul 1.
doi: 10.1038/s41582-019-0221-1. [Epub ahead of print] Review. PubMed PMID: 31263257.

Gorelashvili MG, Angay O, Hemmen K, Klaus V, Stegner D, Heinze KG. Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics. Haematologica. 2019 Jun 27. pii: haematol.2018.202010.
doi: 10.3324/haematol.2018.202010. [Epub ahead of print] PubMed PMID: 31248970.

Kiran Gotru S, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM, Braun A. Defective Zn(2+) homeostasis in mouse and human platelets with α- and δ-storage pool diseases. Sci Rep. 2019 Jun 6;9(1):8333.
doi: 10.1038/s41598-019-44751-w. PubMed PMID: 31171812; PubMed Central PMCID: PMC6554314.

Neidler S, Kruspig B, Hewit K, Monteverde T, Gyuraszova K, Braun A, Clark W, James D, Hedley A, Nieswandt B, Shanks E, Dick C, Murphy DJ. Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma. Cancers (Basel). 2019 Apr 29;11(5). pii: E600.
doi: 10.3390/cancers11050600. PubMed PMID: 31032816; PubMed Central PMCID: PMC6562816.

Schuhmann MK, Kraft P, Bieber M, Kollikowski AM, Schulze H, Nieswandt B, Pham M, Stegner D, Stoll G. Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice. Int J Mol Sci. 2019 Apr 24;20(8). pii: E2019.
doi: 10.3390/ijms20082019. PubMed PMID: 31022936; PubMed Central PMCID: PMC6515069.

Volz J, Mammadova-Bach E, Gil-Pulido J, Nandigama R, Remer K, Sorokin L, Zernecke A, Abrams SI, Ergün S, Henke E, Nieswandt B. Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice. Blood. 2019 Jun 20;133(25):2696-2706.
doi: 10.1182/blood.2018877043. Epub 2019 Apr 5. PubMed PMID: 30952674.

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O’Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN,  Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M. Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat Med. 2019 Apr;25(4):641-655.
doi: 10.1038/s41591-019-0379-5. Epub 2019 Apr 1. PubMed PMID: 30936549.

Rayes J, Watson SP, Nieswandt B. Functional significance of the platelet immune receptors GPVI and CLEC-2. J Clin Invest. 2019 Jan 2;129(1):12-23.
doi: 10.1172/JCI122955. Epub 2019 Jan 2. Review. PubMed PMID: 30601137; PubMed Central PMCID: PMC6307936.

Noy PJ, Gavin RL, Colombo D, Haining EJ, Reyat JS, Payne H, Thielmann I, Lokman AB, Neag G, Yang J, Lloyd T, Harrison N, Heath VL, Gardiner C, Whitworth KM, Robinson J, Koo CZ, Di Maio A, Harrison P, Lee SP, Michelangeli F, Kalia N, Rainger GE, Nieswandt B, Brill A, Watson SP, Tomlinson MG. Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells. Haematologica. 2018 Dec 20. pii: haematol.2018.194241.
doi: 10.3324/haematol.2018.194241. [Epub ahead of print] PubMed PMID: 30573509.

Bieber M, Schuhmann MK, Volz J, Kumar GJ, Vaidya JR, Nieswandt B, Pham M, Stoll G, Kleinschnitz C, Kraft P. Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function. Stroke. 2019 Feb;50(2):478-486.
doi:  0.1161/STROKEAHA.118.023664. PubMed PMID: 30566040; PubMed Central PMCID: PMC6358218.

Mammadova-Bach E, Nagy M, Heemskerk JWM, Nieswandt B, Braun A. Store-operated calcium entry in thrombosis and thrombo-inflammation. Cell Calcium. 2019 Jan;77:39-48.
doi: 10.1016/j.ceca.2018.11.005. Epub 2018 Nov 23. Review. PubMed PMID: 30530092.

Schurr Y, Spindler M, Kurz H, Bender M. The cytoskeletal crosslinking protein MACF1 is dispensable for thrombus formation and hemostasis. Sci Rep. 2019 May 22;9(1):7726.
doi: 10.1038/s41598-019-44183-6. PubMed PMID: 31118482; PubMed Central PMCID: PMC6531446.

2018

Albert-Weissenberger C, Hopp S, Nieswandt B, Sirén AL, Kleinschnitz C, Stetter C. How is the formation of microthrombi after traumatic brain injury linked to inflammation? J Neuroimmunol. 2018;326:9-13. doi: 10.1016/j.jneuroim.2018.10.011.

Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W. Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nat Commun. 2018;9(1):4805. doi: 10.1038/s41467-018-07213-x.

de Winde CM, Matthews AL, van Deventer S, van der Schaaf A, Tomlinson ND, Jansen E, Eble JA, Nieswandt B, McGettrick HM, Figdor CG, Tomlinson MG, Acton SE, van Spriel AB. C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37. J Cell Sci. 2018;131(19). pii: jcs214551. doi: 10.1242/jcs.214551.

Manukjan G, Eilenberger J, Andres O, Schambeck C, Eber S, Schulze H. Functional classification of pediatric patients with non-syndromic delta-storage pool deficiency. Hämostaseologie. 2018 Nov 21. doi: 10.1055/s-0038-1675574.

Aurbach K, Spindler M, Haining EJ, Bender M, Pleines I. Blood collection, platelet isolation and measurement of platelet count and size in mice – a practical guide. Platelets. 2018:1-10. doi: 10.1080/09537104.2018.1528345.

Mammadova-Bach E, Mauler M, Braun A, Duerschmied D. Autocrine and paracrine regulatory functions of platelet serotonin. Platelets. 2018 Sep;29(6):541-548. doi: 10.1080/09537104.2018.1478072.

Gorelashvili MG, Heinze KG, Stegner D. Optical Clearing of Murine Bones to Study Megakaryocytes in Intact Bone Marrow Using Light-Sheet Fluorescence Microscopy. Methods Mol Biol. 2018;1812:233-253. doi: 10.1007/978-1-4939-8585-2_14.

Mekala SR, Wörsdörfer R, Bauer J, Stoll O, Wagner N, Reeh L, Loew K, Eckner G, Kwok CK, Wischmeyer E, Dickinson ME, Schulze H, Stegner D, Benndorf RA, Edenhofer F, Pfeiffer V, Kuerten S, Frantz S, Ergün S. Generation of Cardiomyocytes From Vascular Adventitia-Resident Stem Cells. Circ Res. 2018;123:686-99.

Bender M, Otto O. No Escape-A Novel Tool to Quantify Platelet Intra-Thrombus Movements. Thromb Haemost. 2018 Aug 15. doi: 10.1055/s-0038-1668587.

Spindler M, van Eeuwijk JMM, Schurr Y, Nurden P, Nieswandt B, Stegner D, Reinhold A, Bender M. ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia. Blood. 2018 Aug 9;132(6):635-646. doi: 10.1182/blood-2018-01-829259.

Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC. Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion. Blood. 2018 Jul 12;132(2):197-209. doi: 10.1182/blood-2017-11-816355.

Pleines I, Cherpokova D, Bender M. Rho GTPases and their downstream effectors in megakaryocyte biology. Platelets. 2018 Jun 18:1-8. doi: 10.1080/09537104.2018.1478071.

Schulze H, Stegner D. Imaging platelet biogenesis in vivo. Res Pract Thromb Haemost. 2018 Jun 10;2(3):461-468. doi: 10.1002/rth2.12112.

Andres O, Henning K, Strauß G, Pflug A, Manukjan G, Schulze H. Diagnosis of platelet function disorders: A standardized, rational, and modular flow cytometric approach. Platelets. 2018 Jun;29(4):347-356. doi: 10.1080/09537104.2017.1386297.

Cao H, Biondo M, Lioe H, Busfield S, Rayzman V, Nieswandt B, Bork K, Harrison LC, Auyeung P, Farkas H, Csuka D, Pelzing M, Dower S, Wilson MJ, Nash A, Nolte MW, Panousis C. Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation. J Allergy Clin Immunol. 2018 Jun 21. pii: S0091-6749(18)30901-1. doi: 10.1016/j.jaci.2018.06.014.

Giles JA, Greenhalgh AD, Denes A, Nieswandt B, Coutts G, McColl BW, Allan SM.  Neutrophil infiltration to the brain is platelet-dependent, and is reversed by blockade of platelet GPIbα. Immunology. 2018 Jun;154(2):322-328. doi: 10.1111/imm.12892.

Stritt S, Birkholz I, Beck S, Sorrentino S, Sapra KT, Viaud J, Heck J, Gaits-Iacovoni F, Schulze H, Du X, Hartwig JH, Braun A, Bender M, Medalia O, Nieswandt B. Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets. Blood Adv. 2018 May 8;2(9):1040-1045. doi:10.1182/bloodadvances.2017014001.

Pircher J, Czermak T, Ehrlich A, Eberle C, Gaitzsch E, Margraf A, Grommes J, Saha P, Titova A, Ishikawa-Ankerhold H, Stark K, Petzold T, Stocker T, Weckbach LT, Novotny J, Sperandio M, Nieswandt B, Smith A, Mannell H, Walzog B, Horst D, Soehnlein O, Massberg S, Schulz C. Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation. Nat Commun. 2018 Apr 18;9(1):1523. doi: 10.1038/s41467-018-03925-2.

Gotru SK, Gil-Pulido J, Beyersdorf N, Diefenbach A, Becker IC, Vögtle T, Remer K, Chubanov V, Gudermann T, Hermanns HM, Nieswandt B, Kerkau T, Zernecke A, Braun A. Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice. J Immunol. 2018 Apr 15;200(8):2529-2534. doi: 10.4049/jimmunol.1701467.

Nagy M, Mastenbroek TG, Mattheij NJA, de Witt S, Clemetson KJ, Kirschner J, Schulz AS, Vraetz T, Speckmann C, Braun A, Cosemans JMEM, Zieger B, Heemskerk JWM. Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies. Haematologica. 2018 Mar;103(3):540-549. doi: 10.3324/haematol.2017.176974.

Gupta S, Cherpokova D, Spindler M, Morowski M, Bender M, Nieswandt B. GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice. Blood. 2018 Mar 8;131(10):1106-1110. doi: 10.1182/blood-2017-08-800136.

Rayes J, Jadoui S, Lax S, Gros A, Wichaiyo S, Ollivier V, Denis CV, Ware J, Nieswandt B, Jandrot-Perrus M, Watson SP, Ho-Tin-Noé B. The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent. Haematologica. 2018 Jun;103(6):e256-e258. doi: 10.3324/haematol.2017.182162. Epub 2018 Feb 1.

Claushuis TAM, de Vos AF, Nieswandt B, Boon L, Roelofs JJTH, de Boer OJ, van  ‘t Veer C, van der Poll T. Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria. Blood. 2018 Feb 22;131(8):864-876. doi: 10.1182/blood-2017-06-788067.

Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice. Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):344-352. doi: 10.1161/ATVBAHA.117.310391.

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E. Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115.

Schuhmann MK, Kraft P, Bieber M, Haarmann A, Homola GA, Pham M, Nieswandt B, Stoll G. Influence of Thrombolysis on the Safety and Efficacy of Blocking Platelet Adhesion or Secretory Activity in Acute Ischemic Stroke in Mice. Transl Stroke Res. 2018 Jan 10. doi: 10.1007/s12975-017-0606-7.

2017

Münzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez Menendez I, Märklin M, Quintanilla-Martinez L, Salih HR, Litchfield DW, Buchou T, Kleinschnitz C, Lang F, Nieswandt B, Pleines I, Schulze H, Gawaz M, Borst O. CK2β regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis. Blood. 2017 Dec 21;130(25):2774-2785. doi: 10.1182/blood-2017-05-784413.

Haining EJ, Matthews AL, Noy PJ, Romanska HM, Harris HJ, Pike J, Morowski M, Gavin RL, Yang J, Milhiet PE, Berditchevski F, Nieswandt B, Poulter NS, Watson SP, Tomlinson MG. Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation. Platelets. 2017 Nov;28(7):629-642. doi: 10.1080/09537104.2016.1254175.

Haining EJ, Cherpokova D, Wolf K, Becker IC, Beck S, Eble JA, Stegner D, Watson SP, Nieswandt B. CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice. Blood. 2017 Nov 16;130(20):2224-2228. doi: 10.1182/blood-2017-03-771907.

Manukjan G, Bösing H, Schmugge M, Strauß G, Schulze H. Impact of genetic variants on haematopoiesis in patients with thrombocytopenia absent radii (TAR) syndrome. Br J Haematol. 2017 Nov;179(4):606-617. doi: 10.1111/bjh.14913.

Beck S, Leitges M, Stegner D. Protein kinase Cι/λ is dispensable for platelet function in thrombosis and hemostasis in mice. Cell Signal. 2017 Oct;38:223-229.  doi: 10.1016/j.cellsig.2017.07.015.

Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, Stegner D, Dudeck J, Weber F, Rödiger M, Göpfert C, Drube J, Reich D, Nieswandt B, Dudeck A, Kamradt T. The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis. J Immunol. 2017 Oct 15;199(8):2948-2957. doi: 10.4049/jimmunol.1700556.

Stritt S, Beck S, Becker IC, Vögtle T, Hakala M, Heinze KG, Du X, Bender M, Braun A, Lappalainen P, Nieswandt B. Twinfilin 2a regulates platelet reactivity and turnover in mice. Blood. 2017 Oct 12;130(15):1746-1756. doi: 10.1182/blood-2017-02-770768.

Schulze H, Schlagenhauf A, Manukjan G, Beham-Schmid C, Andres O, Klopocki E, König EM, Haidl H, Panzer S, Althaus K, Muntean WE, Schwinger W, Urban C, Greinacher A, Bakchoul T, Seidel MG. Recessive grey platelet-like syndrome with unaffected erythropoiesis in the absence of the splice isoform GFI1B-p37. Haematologica. 2017 Sep;102(9):e375-e378. doi: 10.3324/haematol.2017.167957.

Stegner D, van Eeuwijk JMM, Angay O, Gorelashvili MG, Semeniak D, Pinnecker J, Schmithausen P, Meyer I, Friedrich M, Dütting S, Brede C, Beilhack A, Schulze H, Nieswandt B, Heinze KG. Thrombopoiesis is spatially regulated by the bone marrow vasculature. Nat Commun. 2017 Jul 25;8(1):127. doi: 10.1038/s41467-017-00201-7.

Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B. A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.

Mammadova-Bach E, Mauler M, Braun A, Duerschmied D. Immuno-Thrombotic Effects of Platelet Serotonin. Chapter 12: Book Neuroscience “Serotonin – A Chemical Messenger Between All Types of Living Cells”, 2017;10.5772/intechopen.69349.

Bender M, Stegner D, Nieswandt B. Model systems for platelet receptor shedding. Platelets. 2017 Jun;28(4):325-332. doi: 10.1080/09537104.2016.1195491.

Jamasbi J, Ayabe K, Goto S, Nieswandt B, Peter K, Siess W. Platelet receptors as therapeutic targets: Past, present and future. Thromb Haemost. 2017 Jun 28;117(7):1249-1257. doi: 10.1160/TH16-12 0911.

Andres O, Wiegering V, König EM, Schneider AL, Semeniak D, Stritt S, Klopocki E, Schulze H. A novel two-nucleotide deletion in HPS6 affects mepacrine uptake and platelet dense granule secretion in a family with Hermansky-Pudlak syndrome. Pediatr Blood Cancer. 2017 May;64(5). doi: 10.1002/pbc.26320.

Ta-Shma A, Zhang K, Salimova E, Zernecke A, Sieiro-Mosti D, Stegner D, Furtado M, Shaag A, Perles Z, Nieswandt B, Rein AJ, Rosenthal N, Neiman AM, Elpeleg O. Congenital valvular defects associated with deleterious mutations in the PLD1 gene. J Med Genet. 2017 Apr;54(4):278-286. doi: 10.1136/jmedgenet-2016-104259.

Deppermann C, Kraft P, Volz J, Schuhmann MK, Beck S, Wolf K, Stegner D, Stoll G, Nieswandt B. Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice. Blood. 2017 Mar 23;129(12):1702-1706. doi: 10.1182/blood-2016-12-750711.

Pierre S, Linke B, Suo J, Tarighi N, Del Turco D, Thomas D, Ferreiros N, Stegner D, Frölich S, Sisignano M, Meyer Dos Santos S, deBruin N, Nüsing RM, Deller T, Nieswandt B, Geisslinger G, Scholich K. GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation. J Invest Dermatol. 2017 Mar;137(3):686-695. doi: 10.1016/j.jid.2016.09.036.

Nagy M, Mastenbroek TG, Mattheij NJA, de Witt S, Clemetson KJ, Kirschner J, Schulz AS, Vraetz T, Speckmann C, Braun A, Cosemans JMEM, Zieger B, Heemskerk JWM. Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies. Haematologica. 2018 Mar;103(3):540-549. doi: 10.3324/ haematol.2017.176974.

Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K,  Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT. Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154.

Latorre-Rey LJ, Wintterle S, Dütting S, Kohlscheen S, Abel T, Schenk F, Wingert S, Rieger MA, Nieswandt B, Heinz N, Modlich U. Targeting expression to megakaryocytes and platelets by lineage-specific lentiviral vectors. J Thromb Haemost. 2017 Feb;15(2):341-355. doi: 10.1111/jth.13582.

Schuhmann MK, Guthmann J, Stoll G, Nieswandt B, Kraft P, Kleinschnitz C. Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke. J Neuroinflammation. 2017 Jan 21;14(1):18. doi: 10.1186/s12974-017-0792-y.

Vorlova S, Koch M, Manthey HD, Cochain C, Busch M, Chaudhari SM, Stegner D, Yepes M, Lorenz K, Nolte MW, Nieswandt B, Zernecke A. Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice. Thromb Haemost. 2017 Jan 5;117(1):176-187. doi: 10.1160/TH16-06-0466.