Publications

2024

Le Chapelain O, Jadoui S, Gros A, Barbaria S, Benmeziane K, Ollivier V, Dupont S, Solo Nomenjanahary M, Mavouna S, Rogozarski J, Mawhin MA, Caligiuri G, Delbosc S, Porteu F, Nieswandt B, Mangin PH, Boulaftali Y, Ho-Tin-Noé B. . The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent.. (2024) J Exp Clin Cancer Res. 2024 Mar. 10.1186/s13046-024-03001-2. 38493157

Granja TF, Köhler D, Tang L, Burkard P, Eggstein C, Hemmen K, Heinze KG, Heck-Swain KL, Koeppen M, Günther S, Blaha MK, Magunia H, Bamberg M, Konrad FM, Ngamsri KC, Fuhr A, Keller M, Bernard A, Haeberle H, Bakchoul T, Zarbock A, Nieswandt B, Rosenberger P. . Semaphorin 7A coordinates Neutrophil response during pulmonary inflammation and sepsis.. (2024) Blood advances. 10.1182/bloodadvances.2023011778. 38489236

Wang X, Slater, A, Lee S, Harrison N, Pollock N, Bakker S, Navarro S, Nieswandt B, Dafforn T, Garcia A, Watson S, Tomlinson M. Purification and characterisation of the platelet-activating GPVI/FcRgamma complex in SMALPs. (2024) Archives of biochemistry and biophysics 109944. 10.1016/j.abb.2024.109944. 38395124

Sisario D, Spindler M, Ermer KJ, Grütz N, Nicolai L, Gärtner F, Machesky LM, Bender M. Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets. (2024) Cells. 10.3390/cells13040299. 38391912

Derler M, Teubenbacher T, Carapuig A, Nieswandt B, Fessler J, Kolb D, Mussbacher M. Platelets induce endoplasmic reticulum stress in macrophages in vitro. (2024) J Thromb Haemost. 10.1016/j.jtha.2024.01.009. 38278417

Wegner P, Drube J, Ziegler L, Strotmann B, Marquardt R, Küchler C, Groth M, Nieswandt B, Andreas N, Drube S. The Neurobeachin-like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells. (2024) Immunology. 10.1111/imm.13756. 38272677

Seizer P, von Ungern-Sternberg SNI, Haug V, Dicenta V, Rosa A, Butt E, Nöthel M, Rohlfing AK, Sigle M, Nawroth PP, Nussbaum C, Sperandio M, Kusch C, Meub M, Sauer M, Münzer P, Bieber K, Stanger A, Mack AF, Huber R, Brand K, Lehners M, Feil R, Poso A, Krutzke K, Schäffer TE, Nieswandt B, Borst O, May AE, Zernecke A, Gawaz M, Heinz Mann D. . Cyclophilin A is a ligand for RAGE in thrombo-inflammation. (2024) Cardiovasc Res. 10.1093/cvr/cvad189. 38175781

Asquith NL, Carminita E, Camacho V, Rodriguez-Romera A, Stegner D, Freire D, Becker IC, Machlus KR, Khan A, Italiano JE, Jr.. The bone marrow is the primary site of thrombopoiesis. (2024) Blood 143:272-278. 10.1182/blood.2023020895. 37879046

2023

Liu W, Pircher J, Schuermans A, Ain QU, Zhang Z, Honigberg MC, Yalcinkaya M, Nakao T, Pournamadri A, Xiao T, Hajebrahimi MA, Wasner L, Stegner D, Petzold T, Natarajan P, Massberg S, Tall AR, Schulz C, Wang N. Jak2V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross-talk. (2023) Blood. 10.1182/blood.2023022260. 38142422

Liu C, Görlich D, Lowell CA, Italiano JE, Rossaint J, Bender M, Zarbock A, Margraf A.. Thrombopoietin levels in sepsis and septic shock – a systematic review and meta-analysis.. (2023) Clin Chem Lab Med.. 10.1515/cclm-2023-0792. 38037809

Ross JE, Mohan S, Zhang J, Sullivan MJ, Bury L, Lee K, Futchi I, Frantz A, Mcdougal D, Botero JP, Cattaneo M, Cooper N, Downes K, Gresele P, Keenan C, Lee A, Megy K, Morange PE, Morgan NV, Schulze H, Zimowski K, Freson K, Lambert MP. Evaluating the clinical validity of genes related to hemostasis and thrombosis using the ClinGen gene curation framework. (2023) J Thromb Haemost. 10.1016/j.jtha.2023.11.011. 38016518

Navarro S, Vogtle T, Gross N, Preu J, Englert M, Nieswandt B, Bosl MR, Stegner D. Mutations of the dimerization site of glycoprotein (GP) VI result in abolished expression. (2023) Thromb Res 232:89-92. 10.1016/j.thromres.2023.10.016. 37951045

Ballmaier M, Germeshausen M, Schulze H, Andres O, Group THS. THROMKIDplus Patient Registry and Biomaterial Banking for Children with Inherited Platelet Disorders. (2023) Hamostaseologie. 10.1055/a-2117-4639. 37918839

Strauss G, Mott K, Klopocki E, Schulze H. Thrombocytopenia Absent Radius (TAR)-Syndrome: From Current Genetics to Patient Self-Empowerment. (2023) Hamostaseologie 43:252-260. 10.1055/a-2088-1801. 37611607

Gebetsberger J, Mott K, Bernar A, Klopocki E, Streif W, Schulze H. State-of-the-Art Targeted High-Throughput Sequencing for Detecting Inherited Platelet Disorders. (2023) Hamostaseologie 43:244-251. 10.1055/a-2099-3266. 37611606

Kahn SR, Arnold DM, Casari C, Desch KC, Devreese KMJ, Favaloro EJ, Gaertner F, Gouw SC, Gresele P, Griffioen AW, Heger L, Kini RM, Kohli S, Leader A, Lisman T, Lordkipanidze M, Mullins E, Okoye HC, Rosovsky RP, Salles C, Ii, Selby R, Sholzberg M, Stegner D, Violi F, Weyand AC, Williams S, Zheng Z. Illustrated State-of-the-Art Capsules of the ISTH 2023 Congress. (2023) Res Pract Thromb Haemost 7:100193. 10.1016/j.rpth.2023.100193. 37538494

Englert N, Burkard P, Aue A, Rosenwald A, Nieswandt B, Friebe A. Anti-Fibrotic and Anti-Inflammatory Role of NO-Sensitive Guanylyl Cyclase in Murine Lung. (2023) Int J Mol Sci 24. 10.3390/ijms241411661. 37511420

Karwen T, Kolczynska-Matysiak K, Gross C, Loffler MC, Friedrich M, Loza-Valdes A, Schmitz W, Wit M, Dziaczkowski F, Belykh A, Trujillo-Viera J, El-Merahbi R, Deppermann C, Nawaz S, Hastoy B, Demczuk A, Erk M, Wieckowski MR, Rorsman P, Heinze KG, Stegner D, Nieswandt B, Sumara G. Platelet-derived lipids promote insulin secretion of pancreatic beta cells. (2023) EMBO Mol Med 15:e16858. 10.15252/emmm.202216858. 37490001

Burkard P, Schonhart C, Vogtle T, Kohler D, Tang L, Johnson D, Hemmen K, Heinze KG, Zarbock A, Hermanns HM, Rosenberger P, Nieswandt B. A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury. (2023) Blood 142:1463-1477. 10.1182/blood.2023019940. 37441848

Zhao X, Alibhai D, Walsh TG, Tarassova N, Englert M, Birol SZ, Li Y, Williams CM, Neal CR, Burkard P, Cross SJ, Aitken EW, Waller AK, Beltran JB, Gunning PW, Hardeman EC, Agbani EO, Nieswandt B, Hers I, Ghevaert C, Poole AW. Highly efficient platelet generation in lung vasculature reproduced by microfluidics. (2023) Nat Commun 14:4026. 10.1038/s41467-023-39598-9. 37419900

Gotru SK, Mammadova-Bach E, Sogkas G, Schuhmann MK, Schmitt K, Kraft P, Herterich S, Mamtimin M, Pinarci A, Beck S, Stritt S, Han C, Ren P, Freund JN, Klemann C, Ringshausen FC, Heemskerk JWM, Dietrich A, Nieswandt B, Stoll G, Gudermann T, Braun A. MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. (2023) Arterioscler Thromb Vasc Biol 43:1494-1509. 10.1161/ATVBAHA.122.318115. 37381987

Elgheznawy A, Oftering P, Englert M, Mott K, Kaiser F, Kusch C, Gbureck U, Bosl MR, Schulze H, Nieswandt B, Vogtle T, Hermanns HM. Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. (2023) Front Immunol 14:1197894. 10.3389/fimmu.2023.1197894. 37359521

Schurr Y, Reil L, Spindler M, Nieswandt B, Machesky LM, Bender M. The WASH-complex subunit Strumpellin regulates integrin alphaIIbbeta3 trafficking in murine platelets. (2023) Sci Rep 13:9526. 10.1038/s41598-023-36387-8. 37308549

Beck S, Oftering P, Li R, Hemmen K, Nagy M, Wang Y, Zarpellon A, Schuhmann MK, Stoll G, Ruggeri ZM, Heinze KG, Heemskerk JWM, Ruf W, Stegner D, Nieswandt B. Platelet glycoprotein V spatio-temporally controls fibrin formation. (2023) Nat Cardiovasc Res 2:368-382. 10.1038/s44161-023-00254-6. 37206993

Mott K, Schulze H. Isolation, In Vitro Differentiation, and Culture of Murine Megakaryocytes From Fetal Liver and Adult Bone Marrow. (2023) Curr Protoc 3:e783. 10.1002/cpz1.783. 37204185

Manke MC, Roslan A, Walker B, Münzer P, Kollotzek F, Peng B, Mencl S, Coman C, Szepanowski RD, Schulze H, Lieberman AP, Lang F, Gawaz M, Kleinschnitz C, Lukowski R, Ahrends R, Bobe R, Borst O. Niemann-Pick C1 protein regulates platelet membrane-associated calcium ion signaling in thrombo-occlusive diseases in mice. (2023) J Thromb Haemost 21:1957-1966. 10.1016/j.jtha.2023.03.038. 37054918

Weiss LJ, Drayss M, Mott K, Beck S, Unsin D, Just B, Speer CP, Härtel C, Andres O, Schulze H. Ontogenesis of functional platelet subpopulations from preterm and term neonates to adulthood: The PLINIUS study. (2023) Blood Adv 7:4334-4348. 10.1182/bloodadvances.2023009824. 37042931

Clark JC, Martin EM, Moran LA, Di Y, Wang X, Zuidscherwoude M, Brown HC, Kavanagh DM, Hummert J, Eble JA, Nieswandt B, Stegner D, Pollitt AY, Herten DP, Tomlinson MG, Garcia A, Watson SP. Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists. (2023) Commun Biol 6:376. 10.1038/s42003-023-04766-6. 37029319

Spindler M, Mott K, Schulze H, Bender M. Rapid isolation of mature murine primary megakaryocytes by size exclusion via filtration. (2023) Platelets 34:2192289. 10.1080/09537104.2023.2192289. 36992536

Seeling M, Pohnl M, Kara S, Horstmann N, Riemer C, Wohner M, Liang C, Bruckner C, Eiring P, Werner A, Biburger M, Altmann L, Schneider M, Amon L, Lehmann CHK, Lee S, Kunz M, Dudziak D, Schett G, Bauerle T, Lux A, Tuckermann J, Vogtle T, Nieswandt B, Sauer M, Bockmann RA, Nimmerjahn F. Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1. (2023) Immunity 56:1046-1063 e7. 10.1016/j.immuni.2023.02.019. 36948194

Ascheid D, Baumann M, Funke C, Volz J, Pinnecker J, Friedrich M, Hohn M, Nandigama R, Ergun S, Nieswandt B, Heinze KG, Henke E. Image-based modeling of vascular organization to evaluate anti-angiogenic therapy. (2023) Biol Direct 18:10. 10.1186/s13062-023-00365-x. 36922848

Schutte JP, Manke MC, Hemmen K, Munzer P, Schorg BF, Ramos GC, Pogoda M, Dicenta V, Hoffmann SHL, Pinnecker J, Kollotzek F, Zdanyte M, Mueller KaL, Singh Y, Mack AF, Pichler B, Lang F, Nieswandt B, Gawaz M, Heinze KG, Casadei N, Borst O. Platelet-Derived MicroRNAs Regulate Cardiac Remodeling After Myocardial Ischemia. (2023) Circ Res 132:e96-e113. 10.1161/CIRCRESAHA.122.322459. 36891903

Haeberle HA, Calov S, Martus P, Serna-Higuita LM, Koeppen M, Goll A, Bernard A, Zarbock A, Meersch M, Weiss R, Mehrlander M, Marx G, Putensen C, Bakchoul T, Magunia H, Nieswandt B, Mirakaj V, Rosenberger P. Inhaled prostacyclin therapy in the acute respiratory distress syndrome: a randomized controlled multicenter trial. (2023) Respir Res 24:58. 10.1186/s12931-023-02346-0. 36805707

Dirks J, Andres O, Paul L, Manukjan G, Schulze H, Morbach H. IgD shapes the pre-immune naïve B cell compartment in humans. (2023) Front Immunol 14:1096019. 10.3389/fimmu.2023.1096019. 36776874

Lee RH, Rocco DJ, Nieswandt B, Bergmeier W. The CalDAG-GEFI/Rap1/alphaIIbbeta3 axis minimally contributes to accelerated platelet clearance in mice with constitutive store-operated calcium entry. (2023) Platelets 34:2157383. 10.1080/09537104.2022.2157383. 36683325

Nagy Z, Nieswandt B. PDE5A: Key Enzyme to Overcome Platelet Inhibition. (2023) Thromb Haemost 123:131-132. 10.1055/a-2000-8406. 36535656

Fan BE, Ling RR, Ramanathan K, Leung BPL, Lim XR, Chadachan VM, Thirugnanam U, Stegner D, Tu TM. COVID-19 mRNA vaccine-associated cerebral venous thrombosis: Rare adverse event or coincidence?. (2023) Am J Hematol 98:E4-E7. 10.1002/ajh.26773. 36308514

Bura A, De Matteis MA, Bender M, Swinkels M, Versluis J, Jansen AJG, Jurak Begonja A. Oculocerebrorenal syndrome of Lowe protein controls cytoskeletal reorganisation during human platelet spreading. (2023) Br J Haematol 200:87-99. 10.1111/bjh.18478. 36176266

Weiss LJ, Drayss M, Manukjan G, Zeitlhofler M, Kleiss J, Weigel M, Herrmann J, Mott K, Beck S, Burkard P, Lam TT, Althaus K, Bakchoul T, Frantz S, Meybohm P, Nieswandt B, Weismann D, Schulze H. Uncoupling of platelet granule release and integrin activation suggests GPIIb/IIIa as a therapeutic target in COVID-19. (2023) Blood Adv 7:2324-2338. 10.1182/bloodadvances.2022008666. 36053793

Brown HC, Beck S, Navarro S, Di Y, Soriano Jerez EM, Kaczmarzyk J, Thomas SG, Mirakaj V, Watson SP, Nieswandt B, Stegner D. Antibody-mediated depletion of human CLEC-2 in a novel humanized mouse model. (2023) Blood Adv 7:997-1000. 10.1182/bloodadvances.2021006463. 36044387

De Jonckheere B, Kollotzek F, Münzer P, Göb V, Fischer M, Mott K, Coman C, Troppmair NN, Manke M-C, Zdanyte M. Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation. (2023) Nat Cardiovasc Res 2:835-852.

2022

Baumann J, Spindler M, Throm Y, Lubbert M, Bender M. Absence of early platelet increment in healthy mice during decitabine treatment. (2022) Sci Rep 12:22266. 10.1038/s41598-022-26821-8. 36564544

Maqsood Z, Clark JC, Martin EM, Cheung YFH, Moran LA, Watson SET, Pike JA, Di Y, Poulter NS, Slater A, Lange BMH, Nieswandt B, Eble JA, Tomlinson MG, Owen DM, Stegner D, Bridge LJ, Wierling C, Watson SP. Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins. (2022) PLoS Comput Biol 18:e1010708. 10.1371/journal.pcbi.1010708. 36441766

Weiss LJ, Drayss M, Mott K, Droste M, Just B, Arold AM, Nieswandt B, Weismann D, Stegner D, Schulze H. The homophilic CD84 receptor is upregulated on platelets in COVID-19 and sepsis. (2022) Thromb Res 220:121-124. 10.1016/j.thromres.2022.10.011. 36334399

Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, Liu L, Ul Ain Q, Ehreiser V, Weber C, Kilani B, Mertsch P, Gotschke J, Cremer S, Fu W, Lorenz M, Ishikawa-Ankerhold H, Raatz E, El-Nemr S, Gorlach A, Marhuenda E, Stark K, Pircher J, Stegner D, Gieger C, Schmidt-Supprian M, Gaertner F, Almendros I, Kelm M, Schulz C, Hidalgo A, Massberg S. Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease. (2022) Immunity 55:2285-2299 e7. 10.1016/j.immuni.2022.10.001. 36272416

Spindler M, Bergmeier W, Stradal TEB, Zhang J, Siminovitch KA, Nicolai L, Reinhold A, Bender M. Novel insights into mouse models of ectopic proplatelet release. (2022) Blood Adv 6:6135-6139. 10.1182/bloodadvances.2022007824. 36251748

Bieber M, Schuhmann MK, Bellut M, Stegner D, Heinze KG, Pham M, Nieswandt B, Stoll G. Blockade of Platelet Glycoprotein Ibalpha Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion. (2022) Int J Mol Sci 23. 10.3390/ijms23169496. 36012752

Zhang Y, Benz P, Stehle D, Yang S, Kurz H, Feil S, Nagel G, Feil R, Gao S, Bender M. Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes. (2022) Open Biol 12:220058. 10.1098/rsob.220058. 35975649

Navarro S, Starke A, Heemskerk JWM, Kuijpers MJE, Stegner D, Nieswandt B. Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function. (2022) Int J Mol Sci 23. 10.3390/ijms23158610. 35955743

Englert M, Aurbach K, Becker IC, Gerber A, Heib T, Wackerbarth LM, Kusch C, Mott K, Araujo GHM, Baig AA, Dutting S, Knaus UG, Stigloher C, Schulze H, Nieswandt B, Pleines I, Nagy Z. Impaired microtubule dynamics contribute to microthrombocytopenia in RhoB-deficient mice. (2022) Blood Adv 6:5184-5197. 10.1182/bloodadvances.2021006545. 35819450

Stoll G, Schuhmann MK, Nieswandt B, Kollikowski AM, Pham M. An intravascular perspective on hyper-acute neutrophil, T-cell and platelet responses: Similarities between human and experimental stroke. (2022) J Cereb Blood Flow Metab 42:1561-1567. 10.1177/0271678X221105764. 35676801

Baumann J, Sachs L, Otto O, Schoen I, Nestler P, Zaninetti C, Kenny M, Kranz R, Von Eysmondt H, Rodriguez J, Schaffer TE, Nagy Z, Greinacher A, Palankar R, Bender M. Reduced platelet forces underlie impaired hemostasis in mouse models of MYH9-related disease. (2022) Sci Adv 8:eabn2627. 10.1126/sciadv.abn2627. 35584211

Neagoe RaI, Gardiner EE, Stegner D, Nieswandt B, Watson SP, Poulter NS. Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCgamma2 Phosphorylation. (2022) Int J Mol Sci 23. 10.3390/ijms23073746. 35409124

Currie SM, Stegmeyer RI, Mildner K, Breitsprecher L, Zeuschner D, Psathaki OE, Schafer K, Wilkens M, Volkery S, Nieswandt B, Vestweber D. Confocal Real-Time Analysis of Cutaneous Platelet Recruitment during Immune Complex‒Mediated Inflammation. (2022) J Invest Dermatol 142:2724-2732 e3. 10.1016/j.jid.2022.03.011. 35367475

Mwiza JMN, Lee RH, Paul DS, Holle LA, Cooley BC, Nieswandt B, Schug WJ, Kawano T, Mackman N, Wolberg AS, Bergmeier W. Both G protein-coupled and immunoreceptor tyrosine-based activation motif receptors mediate venous thrombosis in mice. (2022) Blood 139:3194-3203. 10.1182/blood.2022015787. 35358299

Lee RH, Ghalloussi D, Harousseau GL, Kenny JP, Kramer PA, Proamer F, Nieswandt B, Flick MJ, Gachet C, Casari C, Eckly A, Bergmeier W. Rasa3 deficiency minimally affects thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance. (2022) JCI Insight 7. 10.1172/jci.insight.155676. 35290242

Nording H, Sauter M, Lin C, Steubing R, Geisler S, Sun Y, Niethammer J, Emschermann F, Wang Y, Zieger B, Nieswandt B, Kleinschnitz C, Simon DI, Langer HF. Activated Platelets Upregulate beta(2) Integrin Mac-1 (CD11b/CD18) on Dendritic Cells, Which Mediates Heterotypic Cell-Cell Interaction. (2022) J Immunol 208:1729-1741. 10.4049/jimmunol.2100557. 35277420

Lickert S, Kenny M, Selcuk K, Mehl JL, Bender M, Fruh SM, Burkhardt MA, Studt JD, Nieswandt B, Schoen I, Vogel V. Platelets drive fibronectin fibrillogenesis using integrin alphaIIbbeta3. (2022) Sci Adv 8:eabj8331. 10.1126/sciadv.abj8331. 35275711

Koo CZ, Matthews AL, Harrison N, Szyroka J, Nieswandt B, Gardiner EE, Poulter NS, Tomlinson MG. The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors. (2022) Int J Mol Sci 23. 10.3390/ijms23052440. 35269584

Hearn JI, Green TN, Hisey CL, Bender M, Josefsson EC, Knowlton N, Baumann J, Poulsen RC, Bohlander SK, Kalev-Zylinska ML. Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation. (2022) Blood 139:2673-2690. 10.1182/blood.2021014000. 35245376

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'connor T, Weston CJ, Chauhan A, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M. Author Correction: Platelet GPIbalpha is a mediator and potential interventional target for NASH and subsequent liver cancer. (2022) Nat Med 28:600. 10.1038/s41591-022-01693-7. 35181768

Rosa A, Butt E, Hopper CP, Loroch S, Bender M, Schulze H, Sickmann A, Vorlova S, Seizer P, Heinzmann D, Zernecke A. Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets. (2022) Int J Mol Sci 23. 10.3390/ijms23031469. 35163387

Becker IC, Nagy Z, Manukjan G, Haffner-Luntzer M, Englert M, Heib T, Vogtle T, Gross C, Bharti R, Dietrich S, Mott K, Heck J, Stegmaier S, Baranowsky A, Schinke T, Schlegel N, Heckel T, Stegner D, Pleines I, Ignatius A, Schulze H, Nieswandt B. G6b-B regulates an essential step in megakaryocyte maturation. (2022) Blood Adv 6:3155-3161. 10.1182/bloodadvances.2021006151. 35134123

Heil HS, Aigner M, Maier S, Gupta P, Evers LMC, Gob V, Kusch C, Meub M, Nieswandt B, Stegner D, Heinze KG. Mapping densely packed alphaIIbbeta3 receptors in murine blood platelets with expansion microscopy. (2022) Platelets 33:849-858. 10.1080/09537104.2021.2023735. 35109754

Sachs L, Wesche J, Lenkeit L, Greinacher A, Bender M, Otto O, Palankar R. Ex vivo anticoagulants affect human blood platelet biomechanics with implications for high-throughput functional mechanophenotyping. (2022) Commun Biol 5:86. 10.1038/s42003-021-02982-6. 35064207

Schanbacher C, Bieber M, Reinders Y, Cherpokova D, Teichert C, Nieswandt B, Sickmann A, Kleinschnitz C, Langhauser F, Lorenz K. ERK1/2 Activity Is Critical for the Outcome of Ischemic Stroke. (2022) Int J Mol Sci 23. 10.3390/ijms23020706. 35054890

Bennett C, Lawrence M, Guerrero JA, Stritt S, Waller AK, Yan Y, Mifsud RW, Ballester-Beltran J, Baig A, Mueller A, Mayer L, Warland J, Penkett CJ, Akbari P, Moreau T, Evans AL, Mookerjee S, Hoffman GJ, Saeb-Parsy K, Adams DJ, Couzens AL, Bender M, Erber WN, Nieswandt B, Read RJ, Ghevaert C. CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia. (2022) Blood 139:2227-2239. 10.1182/blood.2021013113. 35051265

Perrella G, Montague SJ, Brown HC, Garcia Quintanilla L, Slater A, Stegner D, Thomas M, Heemskerk JWM, Watson SP. Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear. (2022) Int J Mol Sci 23. 10.3390/ijms23010493. 35008919

Seyhan M, Ungethum K, Schuhmann MK, Mackenrodt D, Rucker V, Montellano FA, Wiedmann S, Rath D, Geisler T, Nieswandt B, Kraft P, Kleinschnitz C, Heuschmann PU. Feasibility of platelet marker analysis in ischemic stroke patients and their association with one-year outcome. A pilot project within a subsample of the Stroke Induced Cardiac Failure in Mice and Men (SICFAIL) cohort study. (2022) Platelets 33:772-780. 10.1080/09537104.2021.2002834. 34875957

Kollikowski AM, Pham M, Marz AG, Papp L, Nieswandt B, Stoll G, Schuhmann MK. Platelet Activation and Chemokine Release Are Related to Local Neutrophil-Dominant Inflammation During Hyperacute Human Stroke. (2022) Transl Stroke Res 13:364-369. 10.1007/s12975-021-00938-w. 34455571

Scheller I, Beck S, Gob V, Gross C, Neagoe RaI, Aurbach K, Bender M, Stegner D, Nagy Z, Nieswandt B. Thymosin beta4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets. (2022) Haematologica 107:2846-2858. 10.3324/haematol.2021.278537. 34348450

Stegner D, Göb V, Krenzlin V, Beck S, Hemmen K, Schuhmann MK, Schörg BF, Hackenbroch C, May F, Burkard P, Pinnecker J, Zernecke A, Rosenberger P, Greinacher A, Pichler BJ, Heinze KG, Stoll G, Nieswandt B. Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation. (2022) Nat Cardiovasc Res 1:132-141. 10.1038/s44161-021-00017-1.

2021

Navarro S, Stegner D, Nieswandt B, Heemskerk JWM, Kuijpers MJE. Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation. (2021) Int J Mol Sci 23. 10.3390/ijms23010358. 35008781

Gob V, Voll MG, Zimmermann L, Hemmen K, Stoll G, Nieswandt B, Schuhmann MK, Heinze KG, Stegner D. Infarct growth precedes cerebral thrombosis following experimental stroke in mice. (2021) Sci Rep 11:22887. 10.1038/s41598-021-02360-6. 34819574

Vogelsang A, Eichler S, Huntemann N, Masanneck L, Bohnlein H, Schungel L, Willison A, Loser K, Nieswandt B, Kehrel BE, Zarbock A, Gobel K, Meuth SG. Platelet Inhibition by Low-Dose Acetylsalicylic Acid Reduces Neuroinflammation in an Animal Model of Multiple Sclerosis. (2021) Int J Mol Sci 22. 10.3390/ijms22189915. 34576080

Beck S, Stegner D, Loroch S, Baig AA, Gob V, Schumbrutzki C, Eilers E, Sickmann A, May F, Nolte MW, Panousis C, Nieswandt B. Generation of a humanized FXII knock-in mouse-A powerful model system to test novel anti-thrombotic agents. (2021) J Thromb Haemost 19:2835-2840. 10.1111/jth.15488. 34363738

Laukner A, Truchet L, Manukjan G, Schulze H, Langbein-Detsch I, Mueller E, Leeb T, Kehl A. Effects of Cocoa Genotypes on Coat Color, Platelets and Coagulation Parameters in French Bulldogs. (2021) Genes (Basel) 12. 10.3390/genes12071092. 34356108

Megy K, Downes K, Morel-Kopp MC, Bastida JM, Brooks S, Bury L, Leinoe E, Gomez K, Morgan NV, Othman M, Ouwehand WH, Perez Botero J, Rivera J, Schulze H, Trégouët DA, Freson K. GoldVariants, a resource for sharing rare genetic variants detected in bleeding, thrombotic, and platelet disorders: Communication from the ISTH SSC Subcommittee on Genomics in Thrombosis and Hemostasis. (2021) J Thromb Haemost 19:2612-2617. 10.1111/jth.15459. 34355501

Italiano JE, Bender M, Merrill-Skoloff G, Ghevaert C, Nieswandt B, Flaumenhaft R. Microvesicles, but not platelets, bud off from mouse bone marrow megakaryocytes. (2021) Blood 138:1998-2001. 10.1182/blood.2021012496. 34324659

Bieber M, Schuhmann MK, Kollikowski AM, Stegner D, Nieswandt B, Pham M, Stoll G. Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice. (2021) Exp Neurol 344:113804. 10.1016/j.expneurol.2021.113804. 34237320

Manke MC, Geue S, Coman C, Peng B, Kollotzek F, Munzer P, Walker B, Huber SM, Rath D, Sickmann A, Stegner D, Duerschmied D, Lang F, Nieswandt B, Gawaz M, Ahrends R, Borst O. ANXA7 Regulates Platelet Lipid Metabolism and Ca(2+) Release in Arterial Thrombosis. (2021) Circ Res 129:494-507. 10.1161/CIRCRESAHA.121.319207. 34176316

Heib T, Hermanns HM, Manukjan G, Englert M, Kusch C, Becker IC, Gerber A, Wackerbarth LM, Burkard P, Dandekar T, Balkenhol J, Jahn D, Beck S, Meub M, Dutting S, Stigloher C, Sauer M, Cherpokova D, Schulze H, Brakebusch C, Nieswandt B, Nagy Z, Pleines I. RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes. (2021) Cell Rep 35:109102. 10.1016/j.celrep.2021.109102. 33979620

Quach ME, Chen W, Wang Y, Deckmyn H, Lanza F, Nieswandt B, Li R. Differential regulation of the platelet GPIb-IX complex by anti-GPIbbeta antibodies. (2021) J Thromb Haemost 19:2044-2055. 10.1111/jth.15359. 33915031

Weiss LJ, Manukjan G, Pflug A, Winter N, Weigel M, Nagler N, Kredel M, Lam TT, Nieswandt B, Weismann D, Schulze H. Acquired platelet GPVI receptor dysfunction in critically ill patients with sepsis. (2021) Blood 137:3105-3115. 10.1182/blood.2020009774. 33827131

Wagner N, Mott K, Upcin B, Stegner D, Schulze H, Ergun S. CXCL12-Abundant Reticular (CAR) Cells Direct Megakaryocyte Protrusions across the Bone Marrow Sinusoid Wall. (2021) Cells 10. 10.3390/cells10040722. 33804965

Stahnke S, Doring H, Kusch C, De Gorter DJJ, Dutting S, Guledani A, Pleines I, Schnoor M, Sixt M, Geffers R, Rohde M, Musken M, Kage F, Steffen A, Faix J, Nieswandt B, Rottner K, Stradal TEB. Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion. (2021) Curr Biol 31:2051-2064 e8. 10.1016/j.cub.2021.02.043. 33711252

Stegner D, Nieswandt B. XPoRting (poly)phosphates limits thrombosis. (2021) Blood 137:1278-1280. 10.1182/blood.2020008973. 33704397

Clark JC, Neagoe RaI, Zuidscherwoude M, Kavanagh DM, Slater A, Martin EM, Soave M, Stegner D, Nieswandt B, Poulter NS, Hummert J, Herten DP, Tomlinson MG, Hill SJ, Watson SP. Evidence that GPVI is Expressed as a Mixture of Monomers and Dimers, and that the D2 Domain is not Essential for GPVI Activation. (2021) Thromb Haemost 121:1435-1447. 10.1055/a-1401-5014. 33638140

Schuhmann MK, Bieber M, Franke M, Kollikowski AM, Stegner D, Heinze KG, Nieswandt B, Pham M, Stoll G. Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice. (2021) J Neuroinflammation 18:46. 10.1186/s12974-021-02095-1. 33602266

Bender M, Palankar R. Platelet Shape Changes during Thrombus Formation: Role of Actin-Based Protrusions. (2021) Hamostaseologie 41:14-21. 10.1055/a-1325-0993. 33588449

Cullmann K, Jahn M, Spindler M, Schenk F, Manukjan G, Mucci A, Steinemann D, Boller K, Schulze H, Bender M, Moritz T, Modlich U. Forming megakaryocytes from murine-induced pluripotent stem cells by the inducible overexpression of supporting factors. (2021) Res Pract Thromb Haemost 5:111-124. 10.1002/rth2.12453. 33537535

Althaus K, Marini I, Zlamal J, Pelzl L, Singh A, Haberle H, Mehrlander M, Hammer S, Schulze H, Bitzer M, Malek N, Rath D, Bosmuller H, Nieswandt B, Gawaz M, Bakchoul T, Rosenberger P. Antibody-induced procoagulant platelets in severe COVID-19 infection. (2021) Blood 137:1061-1071. 10.1182/blood.2020008762. 33512415

Jadoui S, Le Chapelain O, Ollivier V, Mostefa-Kara A, Di Meglio L, Dupont S, Gros A, Nomenjanahary MS, Desilles JP, Mazighi M, Nieswandt B, Loyau S, Jandrot-Perrus M, Mangin PH, Ho-Tin-Noe B. Glenzocimab does not impact glycoprotein VI-dependent inflammatory haemostasis. (2021) Haematologica 106:2000-2003. 10.3324/haematol.2020.270439. 33375772

Gadi I, Fatima S, Elwakiel A, Nazir S, Mohanad Al-Dabet M, Rana R, Bock F, Manoharan J, Gupta D, Biemann R, Nieswandt B, Braun-Dullaeus R, Besler C, Scholz M, Geffers R, Griffin JH, Esmon CT, Kohli S, Isermann B, Shahzad K. Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently. (2021) Circ Res 128:513-529. 10.1161/CIRCRESAHA.120.317219. 33353373

Janus-Bell E, Ahmed MU, Receveur N, Mouriaux C, Nieswandt B, Gardiner EE, Gachet C, Jandrot-Perrus M, Mangin PH. Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability. (2021) Thromb Haemost 121:543-546. 10.1055/s-0040-1718737. 33124026

Chen C, Rawat D, Samikannu B, Bender M, Preissner KT, Linn T. Platelet glycoprotein VI-dependent thrombus stabilization is essential for the intraportal engraftment of pancreatic islets. (2021) Am J Transplant 21:2079-2089. 10.1111/ajt.16375. 33099857

Heib T, Gross C, Muller ML, Stegner D, Pleines I. Isolation of murine bone marrow by centrifugation or flushing for the analysis of hematopoietic cells - a comparative study. (2021) Platelets 32:601-607. 10.1080/09537104.2020.1797323. 32726163

Bornert A, Boscher J, Pertuy F, Eckly A, Stegner D, Strassel C, Gachet C, Lanza F, Leon C. Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation. (2021) Haematologica 106:1368-1380. 10.3324/haematol.2019.239111. 32327502

Haining EJ, Lowe KL, Wichaiyo S, Kataru RP, Nagy Z, Kavanagh DP, Lax S, Di Y, Nieswandt B, Ho-Tin-Noe B, Mehrara BJ, Senis YA, Rayes J, Watson SP. Lymphatic blood filling in CLEC-2-deficient mouse models. (2021) Platelets 32:352-367. 10.1080/09537104.2020.1734784. 32129691

2020

Balkenhol J, Kaltdorf KV, Mammadova-Bach E, Braun A, Nieswandt B, Dittrich M, Dandekar T. Comparison of the central human and mouse platelet signaling cascade by systems biological analysis. (2020) BMC Genomics 21:897. 10.1186/s12864-020-07215-4. 33353544

Pfeil EM, Brands J, Merten N, Vogtle T, Vescovo M, Rick U, Albrecht IM, Heycke N, Kawakami K, Ono Y, Ngako Kadji FM, Hiratsuka S, Aoki J, Haberlein F, Matthey M, Garg J, Hennen S, Jobin ML, Seier K, Calebiro D, Pfeifer A, Heinemann A, Wenzel D, Konig GM, Nieswandt B, Fleischmann BK, Inoue A, Simon K, Kostenis E. Heterotrimeric G Protein Subunit Galphaq Is a Master Switch for Gbetagamma-Mediated Calcium Mobilization by Gi-Coupled GPCRs. (2020) Mol Cell 80:940-954 e6. 10.1016/j.molcel.2020.10.027. 33202251

Nicolai L, Schiefelbein K, Lipsky S, Leunig A, Hoffknecht M, Pekayvaz K, Raude B, Marx C, Ehrlich A, Pircher J, Zhang Z, Saleh I, Marel AK, Lof A, Petzold T, Lorenz M, Stark K, Pick R, Rosenberger G, Weckbach L, Uhl B, Xia S, Reichel CA, Walzog B, Schulz C, Zheden V, Bender M, Li R, Massberg S, Gaertner F. Vascular surveillance by haptotactic blood platelets in inflammation and infection. (2020) Nat Commun 11:5778. 10.1038/s41467-020-19515-0. 33188196

Salzmann M, Schrottmaier WC, Kral-Pointner JB, Mussbacher M, Volz J, Hoesel B, Moser B, Bleichert S, Morava S, Nieswandt B, Schmid JA, Assinger A. Genetic platelet depletion is superior in platelet transfusion compared to current models. (2020) Haematologica 105:2698. 10.3324/haematol.2020.266072. 33131266

Gupta S, Konradt C, Corken A, Ware J, Nieswandt B, Di Paola J, Yu M, Wang D, Nieman MT, Whiteheart SW, Brass LF. Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation. (2020) Proc Natl Acad Sci U S A 117:24316-24325. 10.1073/pnas.2007642117. 32929010

Schuhmann MK, Stoll G, Bieber M, Vogtle T, Hofmann S, Klaus V, Kraft P, Seyhan M, Kollikowski AM, Papp L, Heuschmann PU, Pham M, Nieswandt B, Stegner D. CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke. (2020) Circ Res 127:1023-1035. 10.1161/CIRCRESAHA.120.316655. 32762491

Volz J, Kusch C, Beck S, Popp M, Vogtle T, Meub M, Scheller I, Heil HS, Preu J, Schuhmann MK, Hemmen K, Premsler T, Sickmann A, Heinze KG, Stegner D, Stoll G, Braun A, Sauer M, Nieswandt B. BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation. (2020) J Clin Invest 130:6064-6079. 10.1172/JCI136457. 32750041

Bacher C, Bender M, Gekle S. Flow-accelerated platelet biogenesis is due to an elasto-hydrodynamic instability. (2020) Proc Natl Acad Sci U S A 117:18969-18976. 10.1073/pnas.2002985117. 32719144

Ariens R, Becattini C, Bender M, Bergmeier W, Castoldi E, Devreese K, Ellis M, Gailani D, Ignjatovic V, James PD, Kerrigan S, Lambert M, Lee LH, Levi M, Maugeri N, Meijers J, Melero-Martin J, Michelson AD, Mingozzi F, Neeves K, Ni H, Olsson AK, Prohaszka Z, Ranson M, Riva N, Senis Y, Van Ommen CH, Vaughan DE, Weisel J. Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress. (2020) Res Pract Thromb Haemost 4:680-713. 10.1002/rth2.12368. 32685876

Burkard P, Vogtle T, Nieswandt B. Platelets in Thrombo-Inflammation: Concepts, Mechanisms, and Therapeutic Strategies for Ischemic Stroke. (2020) Hamostaseologie 40:153-164. 10.1055/a-1151-9519. 32455457

Becker IC, Scheller I, Wackerbarth LM, Beck S, Heib T, Aurbach K, Manukjan G, Gross C, Spindler M, Nagy Z, Witke W, Lappalainen P, Bender M, Schulze H, Pleines I, Nieswandt B. Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1. (2020) Blood Adv 4:2124-2134. 10.1182/bloodadvances.2019001303. 32407474

Kohler D, Granja T, Volz J, Koeppen M, Langer HF, Hansmann G, Legchenko E, Geisler T, Bakchoul T, Eggstein C, Haberle HA, Nieswandt B, Rosenberger P. Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. (2020) Nat Commun 11:1315. 10.1038/s41467-020-14958-x. 32161256

Stegner D, Heinze KG. Intravital imaging of megakaryocytes. (2020) Platelets 31:599-609. 10.1080/09537104.2020.1738366. 32153253

Scheller I, Nieswandt B. Novel Approaches to Unravel Risk Factors and Mechanisms of Venous Thrombosis. (2020) Thromb Haemost 120:372. 10.1055/s-0040-1702232. 32135564

Bertovic I, Kurelic R, Milosevic I, Bender M, Krauss M, Haucke V, Jurak Begonja A. Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes. (2020) J Thromb Haemost 18:1756-1772. 10.1111/jth.14764. 32056354

Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, Burkard P, Shityakov S, Schonhart C, Stegner D, Remer K, Nurden P, Nurden AT, Dandekar T, Nehez L, Dank M, Braun A, Mezzano D, Abrams SI, Nieswandt B. Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3. (2020) Blood 135:1146-1160. 10.1182/blood.2019002649. 32040544

Vogtle T, Baig AA, Volz J, Duchow TB, Pleines I, Dutting S, Nitschke L, Watson SP, Nieswandt B. Critical redundant functions of the adapters Grb2 and Gads in platelet (hem)ITAM signaling in mice. (2020) Platelets 31:801-811. 10.1080/09537104.2019.1709633. 31948362

Green HLH, Zuidscherwoude M, Alenazy F, Smith CW, Bender M, Thomas SG. SMIFH2 inhibition of platelets demonstrates a critical role for formin proteins in platelet cytoskeletal dynamics. (2020) J Thromb Haemost 18:955-967. 10.1111/jth.14735. 31930764

Kollikowski AM, Schuhmann MK, Nieswandt B, Mullges W, Stoll G, Pham M. Local Leukocyte Invasion during Hyperacute Human Ischemic Stroke. (2020) Ann Neurol 87:466-479. 10.1002/ana.25665. 31899551

Rommel MGE, Milde C, Eberle R, Schulze H, Modlich U. Endothelial-platelet interactions in influenza-induced pneumonia: A potential therapeutic target. (2020) Anat Histol Embryol 49:606-619. 10.1111/ahe.12521. 31793053

Dunster JL, Unsworth AJ, Bye AP, Haining EJ, Sowa MA, Di Y, Sage T, Pallini C, Pike JA, Hardy AT, Nieswandt B, Garcia A, Watson SP, Poulter NS, Gibbins JM, Pollitt AY. Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. (2020) J Thromb Haemost 18:485-496. 10.1111/jth.14673. 31680418

Scheller I, Stritt S, Beck S, Peng B, Pleines I, Heinze KG, Braun A, Otto O, Ahrends R, Sickmann A, Bender M, Nieswandt B. Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets. (2020) Haematologica 105:1667-1676. 10.3324/haematol.2019.225516. 31582545

Gorelashvili MG, Angay O, Hemmen K, Klaus V, Stegner D, Heinze KG. Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics. (2020) Haematologica 105:895-904. 10.3324/haematol.2018.202010. 31248970

2019

Eyrich M, Schulze H. HLA Matching in Pediatric Stem Cell Transplantation. (2019) Transfus Med Hemother 46:348-355. 10.1159/000502422. 31832060

Stegner D, Klaus V, Nieswandt B. Platelets as Modulators of Cerebral Ischemia/Reperfusion Injury. (2019) Front Immunol 10:2505. 10.3389/fimmu.2019.02505. 31736950

Schurr Y, Sperr A, Volz J, Beck S, Reil L, Kusch C, Eiring P, Bryson S, Sauer M, Nieswandt B, Machesky L, Bender M. Platelet lamellipodium formation is not required for thrombus formation and stability. (2019) Blood 134:2318-2329. 10.1182/blood.2019002105. 31697813

Geue S, Aurbach K, Manke MC, Manukjan G, Munzer P, Stegner D, Brahler C, Walker-Allgaier B, Marklin M, Borst CE, Quintanilla-Fend L, Rath D, Geisler T, Salih HR, Seizer P, Lang F, Nieswandt B, Gawaz M, Schulze H, Pleines I, Borst O. Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis. (2019) Blood 134:1847-1858. 10.1182/blood.2019000185. 31578203

Stegner D, Hofmann S, Schuhmann MK, Kraft P, Herrmann AM, Popp S, Hohn M, Popp M, Klaus V, Post A, Kleinschnitz C, Braun A, Meuth SG, Lesch KP, Stoll G, Kraft R, Nieswandt B. Loss of Orai2-Mediated Capacitative Ca(2+) Entry Is Neuroprotective in Acute Ischemic Stroke. (2019) Stroke 50:3238-3245. 10.1161/STROKEAHA.119.025357. 31551038

Herster F, Bittner Z, Codrea MC, Archer NK, Heister M, Loffler MW, Heumos S, Wegner J, Businger R, Schindler M, Stegner D, Schakel K, Grabbe S, Ghoreschi K, Miller LS, Weber ANR. Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis. (2019) Front Immunol 10:1867. 10.3389/fimmu.2019.01867. 31474979

Nagy M, Van Geffen JP, Stegner D, Adams DJ, Braun A, De Witt SM, Elvers M, Geer MJ, Kuijpers MJE, Kunzelmann K, Mori J, Oury C, Pircher J, Pleines I, Poole AW, Senis YA, Verdoold R, Weber C, Nieswandt B, Heemskerk JWM, Baaten C. Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis. (2019) Front Cardiovasc Med 6:99. 10.3389/fcvm.2019.00099. 31417909

Semeniak D, Faber K, Öftering P, Manukjan G, Schulze H. Impact of Itga2-Gp6-double collagen receptor deficient mice for bone marrow megakaryocytes and platelets. (2019) PLoS One 14:e0216839. 10.1371/journal.pone.0216839. 31398205

Stoll G, Nieswandt B. Thrombo-inflammation in acute ischaemic stroke - implications for treatment. (2019) Nat Rev Neurol 15:473-481. 10.1038/s41582-019-0221-1. 31263257

Kiran Gotru S, Van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM, Braun A. Defective Zn(2+) homeostasis in mouse and human platelets with alpha- and delta-storage pool diseases. (2019) Sci Rep 9:8333. 10.1038/s41598-019-44751-w. 31171812

Schurr Y, Spindler M, Kurz H, Bender M. The cytoskeletal crosslinking protein MACF1 is dispensable for thrombus formation and hemostasis. (2019) Sci Rep 9:7726. 10.1038/s41598-019-44183-6. 31118482

Neidler S, Kruspig B, Hewit K, Monteverde T, Gyuraszova K, Braun A, Clark W, James D, Hedley A, Nieswandt B, Shanks E, Dick C, Murphy DJ. Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma. (2019) Cancers (Basel) 11. 10.3390/cancers11050600. 31032816

Schuhmann MK, Kraft P, Bieber M, Kollikowski AM, Schulze H, Nieswandt B, Pham M, Stegner D, Stoll G. Targeting Platelet GPVI Plus rt-PA Administration but Not alpha2beta1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice. (2019) Int J Mol Sci 20. 10.3390/ijms20082019. 31022936

Volz J, Mammadova-Bach E, Gil-Pulido J, Nandigama R, Remer K, Sorokin L, Zernecke A, Abrams SI, Ergun S, Henke E, Nieswandt B. Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice. (2019) Blood 133:2696-2706. 10.1182/blood.2018877043. 30952674

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'connor T, Weston CJ, Chauhan A, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M. Platelet GPIbalpha is a mediator and potential interventional target for NASH and subsequent liver cancer. (2019) Nat Med 25:641-655. 10.1038/s41591-019-0379-5. 30936549

Rayes J, Watson SP, Nieswandt B. Functional significance of the platelet immune receptors GPVI and CLEC-2. (2019) J Clin Invest 129:12-23. 10.1172/JCI122955. 30601137

Noy PJ, Gavin RL, Colombo D, Haining EJ, Reyat JS, Payne H, Thielmann I, Lokman AB, Neag G, Yang J, Lloyd T, Harrison N, Heath VL, Gardiner C, Whitworth KM, Robinson J, Koo CZ, Di Maio A, Harrison P, Lee SP, Michelangeli F, Kalia N, Rainger GE, Nieswandt B, Brill A, Watson SP, Tomlinson MG. Tspan18 is a novel regulator of the Ca(2+) channel Orai1 and von Willebrand factor release in endothelial cells. (2019) Haematologica 104:1892-1905. 10.3324/haematol.2018.194241. 30573509

Bieber M, Schuhmann MK, Volz J, Kumar GJ, Vaidya JR, Nieswandt B, Pham M, Stoll G, Kleinschnitz C, Kraft P. Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function. (2019) Stroke 50:478-486. 10.1161/STROKEAHA.118.023664. 30566040

Mammadova-Bach E, Nagy M, Heemskerk JWM, Nieswandt B, Braun A. Store-operated calcium entry in thrombosis and thrombo-inflammation. (2019) Cell Calcium 77:39-48. 10.1016/j.ceca.2018.11.005. 30530092

Manukjan G, Eilenberger J, Andres O, Schambeck C, Eber S, Schulze H. Functional Classification of Paediatric Patients with Non-syndromic Delta-Storage Pool Deficiency. (2019) Hamostaseologie 39:383-391. 10.1055/s-0038-1675574. 30463093

Albert-Weissenberger C, Hopp S, Nieswandt B, Siren AL, Kleinschnitz C, Stetter C. How is the formation of microthrombi after traumatic brain injury linked to inflammation?. (2019) J Neuroimmunol 326:9-13. 10.1016/j.jneuroim.2018.10.011. 30445364

Aurbach K, Spindler M, Haining EJ, Bender M, Pleines I. Blood collection, platelet isolation and measurement of platelet count and size in mice-a practical guide. (2019) Platelets 30:698-707. 10.1080/09537104.2018.1528345. 30346859

Pleines I, Cherpokova D, Bender M. Rho GTPases and their downstream effectors in megakaryocyte biology. (2019) Platelets 30:9-16. 10.1080/09537104.2018.1478071. 29913074

2018

Andres O, König EM, Althaus K, Bakchoul T, Bugert P, Eber S, Knöfler R, Kunstmann E, Manukjan G, Meyer O, Strauß G, Streif W, Thiele T, Wiegering V, Klopocki E, Schulze H. Use of Targeted High-Throughput Sequencing for Genetic Classification of Patients with Bleeding Diathesis and Suspected Platelet Disorder. (2018) TH Open 2:e445-e454. 10.1055/s-0038-1676813. 31249973

Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmuller W. Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. (2018) Nat Commun 9:4805. 10.1038/s41467-018-07213-x. 30442932

Mekala SR, Worsdorfer P, Bauer J, Stoll O, Wagner N, Reeh L, Loew K, Eckner G, Kwok CK, Wischmeyer E, Dickinson ME, Schulze H, Stegner D, Benndorf RA, Edenhofer F, Pfeiffer V, Kuerten S, Frantz S, Ergun S. Generation of Cardiomyocytes From Vascular Adventitia-Resident Stem Cells. (2018) Circ Res 123:686-699. 10.1161/CIRCRESAHA.117.312526. 30355234

De Winde CM, Matthews AL, Van Deventer S, Van Der Schaaf A, Tomlinson ND, Jansen E, Eble JA, Nieswandt B, Mcgettrick HM, Figdor CG, Tomlinson MG, Acton SE, Van Spriel AB. C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37. (2018) J Cell Sci 131. 10.1242/jcs.214551. 30185523

Gorelashvili MG, Heinze KG, Stegner D. Optical Clearing of Murine Bones to Study Megakaryocytes in Intact Bone Marrow Using Light-Sheet Fluorescence Microscopy. (2018) Methods Mol Biol 1812:233-253. 10.1007/978-1-4939-8585-2_14. 30171582

Bender M, Otto O. No Escape-A Novel Tool to Quantify Platelet Intra-Thrombus Movements. (2018) Thromb Haemost 118:1515-1516. 10.1055/s-0038-1668587. 30112752

Schulze H, Stegner D. Imaging platelet biogenesis in vivo. (2018) Res Pract Thromb Haemost 2:461-468. 10.1002/rth2.12112. 30046750

Spindler M, Van Eeuwijk JMM, Schurr Y, Nurden P, Nieswandt B, Stegner D, Reinhold A, Bender M. ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia. (2018) Blood 132:635-646. 10.1182/blood-2018-01-829259. 29950291

Cao H, Biondo M, Lioe H, Busfield S, Rayzman V, Nieswandt B, Bork K, Harrison LC, Auyeung P, Farkas H, Csuka D, Pelzing M, Dower S, Wilson MJ, Nash A, Nolte MW, Panousis C. Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation. (2018) J Allergy Clin Immunol 142:1355-1358. 10.1016/j.jaci.2018.06.014. 29936101

Stritt S, Birkholz I, Beck S, Sorrentino S, Sapra KT, Viaud J, Heck J, Gaits-Iacovoni F, Schulze H, Du X, Hartwig JH, Braun A, Bender M, Medalia O, Nieswandt B. Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets. (2018) Blood Adv 2:1040-1045. 10.1182/bloodadvances.2017014001. 29739775

Pircher J, Czermak T, Ehrlich A, Eberle C, Gaitzsch E, Margraf A, Grommes J, Saha P, Titova A, Ishikawa-Ankerhold H, Stark K, Petzold T, Stocker T, Weckbach LT, Novotny J, Sperandio M, Nieswandt B, Smith A, Mannell H, Walzog B, Horst D, Soehnlein O, Massberg S, Schulz C. Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation. (2018) Nat Commun 9:1523. 10.1038/s41467-018-03925-2. 29670076

Gotru SK, Gil-Pulido J, Beyersdorf N, Diefenbach A, Becker IC, Vogtle T, Remer K, Chubanov V, Gudermann T, Hermanns HM, Nieswandt B, Kerkau T, Zernecke A, Braun A. Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice. (2018) J Immunol 200:2529-2534. 10.4049/jimmunol.1701467. 29581357

Rayes J, Jadoui S, Lax S, Gros A, Wichaiyo S, Ollivier V, Denis CV, Ware J, Nieswandt B, Jandrot-Perrus M, Watson SP, Ho-Tin-Noe B. The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent. (2018) Haematologica 103:e256-e258. 10.3324/haematol.2017.182162. 29419432

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, Mckenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E. Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration. (2018) Proc Natl Acad Sci U S A 115:E1550-E1559. 10.1073/pnas.1720553115. 29386381

Giles JA, Greenhalgh AD, Denes A, Nieswandt B, Coutts G, Mccoll BW, Allan SM. Neutrophil infiltration to the brain is platelet-dependent, and is reversed by blockade of platelet GPIbalpha. (2018) Immunology 154:322-328. 10.1111/imm.12892. 29325217

Schuhmann MK, Kraft P, Bieber M, Haarmann A, Homola GA, Pham M, Nieswandt B, Stoll G. Influence of Thrombolysis on the Safety and Efficacy of Blocking Platelet Adhesion or Secretory Activity in Acute Ischemic Stroke in Mice. (2018) Transl Stroke Res 9:493-498. 10.1007/s12975-017-0606-7. 29322481

Gupta S, Cherpokova D, Spindler M, Morowski M, Bender M, Nieswandt B. GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice. (2018) Blood 131:1106-1110. 10.1182/blood-2017-08-800136. 29295843

Andres O, Henning K, Strauß G, Pflug A, Manukjan G, Schulze H. Diagnosis of platelet function disorders: A standardized, rational, and modular flow cytometric approach. (2018) Platelets 29:347-356. 10.1080/09537104.2017.1386297. 29227167

Claushuis TaM, De Vos AF, Nieswandt B, Boon L, Roelofs J, De Boer OJ, Van 'T Veer C, Van Der Poll T. Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria. (2018) Blood 131:864-876. 10.1182/blood-2017-06-788067. 29187378

Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice. (2018) Arterioscler Thromb Vasc Biol 38:344-352. 10.1161/ATVBAHA.117.310391. 29146750

2017

Munzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez Menendez I, Marklin M, Quintanilla-Martinez L, Salih HR, Litchfield DW, Buchou T, Kleinschnitz C, Lang F, Nieswandt B, Pleines I, Schulze H, Gawaz M, Borst O. CK2beta regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis. (2017) Blood 130:2774-2785. 10.1182/blood-2017-05-784413. 28928125

Drube S, Grimlowski R, Deppermann C, Frobel J, Kraft F, Andreas N, Stegner D, Dudeck J, Weber F, Rodiger M, Gopfert C, Drube J, Reich D, Nieswandt B, Dudeck A, Kamradt T. The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis. (2017) J Immunol 199:2948-2957. 10.4049/jimmunol.1700556. 28887433

Manukjan G, Bösing H, Schmugge M, Strauß G, Schulze H. Impact of genetic variants on haematopoiesis in patients with thrombocytopenia absent radii (TAR) syndrome. (2017) Br J Haematol 179:606-617. 10.1111/bjh.14913. 28857120

Haining EJ, Cherpokova D, Wolf K, Becker IC, Beck S, Eble JA, Stegner D, Watson SP, Nieswandt B. CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice. (2017) Blood 130:2224-2228. 10.1182/blood-2017-03-771907. 28835437

Stegner D, Vaneeuwijk JMM, Angay O, Gorelashvili MG, Semeniak D, Pinnecker J, Schmithausen P, Meyer I, Friedrich M, Dutting S, Brede C, Beilhack A, Schulze H, Nieswandt B, Heinze KG. Thrombopoiesis is spatially regulated by the bone marrow vasculature. (2017) Nat Commun 8:127. 10.1038/s41467-017-00201-7. 28743899

Stritt S, Beck S, Becker IC, Vogtle T, Hakala M, Heinze KG, Du X, Bender M, Braun A, Lappalainen P, Nieswandt B. Twinfilin 2a regulates platelet reactivity and turnover in mice. (2017) Blood 130:1746-1756. 10.1182/blood-2017-02-770768. 28743718

Beck S, Leitges M, Stegner D. Protein kinase Ciota/lambda is dispensable for platelet function in thrombosis and hemostasis in mice. (2017) Cell Signal 38:223-229. 10.1016/j.cellsig.2017.07.015. 28739484

Dutting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, Van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B. A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. (2017) Nat Commun 8:15838. 10.1038/ncomms15838. 28643773

Jamasbi J, Ayabe K, Goto S, Nieswandt B, Peter K, Siess W. Platelet receptors as therapeutic targets: Past, present and future. (2017) Thromb Haemost 117:1249-1257. 10.1160/TH16-12-0911. 28597906

Schulze H, Schlagenhauf A, Manukjan G, Beham-Schmid C, Andres O, Klopocki E, König EM, Haidl H, Panzer S, Althaus K, Muntean WE, Schwinger W, Urban C, Greinacher A, Bakchoul T, Seidel MG. Recessive grey platelet-like syndrome with unaffected erythropoiesis in the absence of the splice isoform GFI1B-p37. (2017) Haematologica 102:e375-e378. 10.3324/haematol.2017.167957. 28550182

Schuhmann MK, Guthmann J, Stoll G, Nieswandt B, Kraft P, Kleinschnitz C. Blocking of platelet glycoprotein receptor Ib reduces "thrombo-inflammation" in mice with acute ischemic stroke. (2017) J Neuroinflammation 14:18. 10.1186/s12974-017-0792-y. 28109273

Deppermann C, Kraft P, Volz J, Schuhmann MK, Beck S, Wolf K, Stegner D, Stoll G, Nieswandt B. Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice. (2017) Blood 129:1702-1706. 10.1182/blood-2016-12-750711. 28077416

Haining EJ, Matthews AL, Noy PJ, Romanska HM, Harris HJ, Pike J, Morowski M, Gavin RL, Yang J, Milhiet PE, Berditchevski F, Nieswandt B, Poulter NS, Watson SP, Tomlinson MG. Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation. (2017) Platelets 28:629-642. 10.1080/09537104.2016.1254175. 28032533

Latorre-Rey LJ, Wintterle S, Dutting S, Kohlscheen S, Abel T, Schenk F, Wingert S, Rieger MA, Nieswandt B, Heinz N, Modlich U. Targeting expression to megakaryocytes and platelets by lineage-specific lentiviral vectors. (2017) J Thromb Haemost 15:341-355. 10.1111/jth.13582. 27930847

Andres O, Wiegering V, König EM, Schneider AL, Semeniak D, Stritt S, Klopocki E, Schulze H. A novel two-nucleotide deletion in HPS6 affects mepacrine uptake and platelet dense granule secretion in a family with Hermansky-Pudlak syndrome. (2017) Pediatr Blood Cancer 64. 10.1002/pbc.26320. 27917594

Pierre S, Linke B, Suo J, Tarighi N, Del Turco D, Thomas D, Ferreiros N, Stegner D, Frolich S, Sisignano M, Meyer Dos Santos S, Debruin N, Nusing RM, Deller T, Nieswandt B, Geisslinger G, Scholich K. GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation. (2017) J Invest Dermatol 137:686-695. 10.1016/j.jid.2016.09.036. 27818280

Ta-Shma A, Zhang K, Salimova E, Zernecke A, Sieiro-Mosti D, Stegner D, Furtado M, Shaag A, Perles Z, Nieswandt B, Rein AJ, Rosenthal N, Neiman AM, Elpeleg O. Congenital valvular defects associated with deleterious mutations in the PLD1 gene. (2017) J Med Genet 54:278-286. 10.1136/jmedgenet-2016-104259. 27799408

Vorlova S, Koch M, Manthey HD, Cochain C, Busch M, Chaudhari SM, Stegner D, Yepes M, Lorenz K, Nolte MW, Nieswandt B, Zernecke A. Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice. (2017) Thromb Haemost 117:176-187. 10.1160/TH16-06-0466. 27786338

Bender M, Stegner D, Nieswandt B. Model systems for platelet receptor shedding. (2017) Platelets 28:325-332. 10.1080/09537104.2016.1195491. 27337269

2016

Pleines I, Nieswandt B. RhoA/ROCK guides NMII on the way to MK polyploidy. (2016) Blood 128:3025-3026. 10.1182/blood-2016-11-746685. 28034868

Baig AA, Haining EJ, Geuss E, Beck S, Swieringa F, Wanitchakool P, Schuhmann MK, Stegner D, Kunzelmann K, Kleinschnitz C, Heemskerk JW, Braun A, Nieswandt B. TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report. (2016) Arterioscler Thromb Vasc Biol 36:2152-2157. 10.1161/ATVBAHA.116.307727. 27634832

Regn M, Laggerbauer B, Jentzsch C, Ramanujam D, Ahles A, Sichler S, Calzada-Wack J, Koenen RR, Braun A, Nieswandt B, Engelhardt S. Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. (2016) J Mol Cell Cardiol 99:57-64. 10.1016/j.yjmcc.2016.08.010. 27539859

Chillo O, Kleinert EC, Lautz T, Lasch M, Pagel JI, Heun Y, Troidl K, Fischer S, Caballero-Martinez A, Mauer A, Kurz ARM, Assmann G, Rehberg M, Kanse SM, Nieswandt B, Walzog B, Reichel CA, Mannell H, Preissner KT, Deindl E. Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function. (2016) Cell Rep 16:2197-2207. 10.1016/j.celrep.2016.07.040. 27524614

Semeniak D, Kulawig R, Stegner D, Meyer I, Schwiebert S, Bosing H, Eckes B, Nieswandt B, Schulze H. Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling. (2016) J Cell Sci 129:3473-84. 10.1242/jcs.187971. 27505889

Stegner D. SePARating thrombosis and hemostasis?. (2016) Thromb Res 145:140-2. 10.1016/j.thromres.2016.07.011. 27470324

Trujillo Viera J, El-Merahbi R, Nieswandt B, Stegner D, Sumara G. Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight. (2016) PLoS One 11:e0157607. 10.1371/journal.pone.0157607. 27299737

Stegner D, Popp M, Lorenz V, Wax JK, Gessner JE, Nieswandt B. FcgammaRIIB on liver sinusoidal endothelial cells is essential for antibody-induced GPVI ectodomain shedding in mice. (2016) Blood 128:862-5. 10.1182/blood-2016-05-714378. 27297794

Gobel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. (2016) Nat Commun 7:11626. 10.1038/ncomms11626. 27188843

Chen W, Spitzl A, Mathes D, Nikolaev VO, Werner F, Weirather J, Spiranec K, Rock K, Fischer JW, Kammerer U, Stegner D, Baba HA, Hofmann U, Frantz S, Kuhn M. Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction. (2016) Circ Res 119:237-48. 10.1161/CIRCRESAHA.115.307196. 27142162

Van Eeuwijk JM, Stegner D, Lamb DJ, Kraft P, Beck S, Thielmann I, Kiefer F, Walzog B, Stoll G, Nieswandt B. The Novel Oral Syk Inhibitor, Bl1002494, Protects Mice From Arterial Thrombosis and Thromboinflammatory Brain Infarction. (2016) Arterioscler Thromb Vasc Biol 36:1247-53. 10.1161/ATVBAHA.115.306883. 27102960

Hopp S, Albert-Weissenberger C, Mencl S, Bieber M, Schuhmann MK, Stetter C, Nieswandt B, Schmidt PM, Monoranu CM, Alafuzoff I, Marklund N, Nolte MW, Siren AL, Kleinschnitz C. Targeting coagulation factor XII as a novel therapeutic option in brain trauma. (2016) Ann Neurol 79:970-82. 10.1002/ana.24655. 27043916

Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, Van Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A. Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture. (2016) Nat Commun 7:11097. 10.1038/ncomms11097. 27020697

May F, Krupka J, Fries M, Thielmann I, Pragst I, Weimer T, Panousis C, Nieswandt B, Stoll G, Dickneite G, Schulte S, Nolte MW. FXIIa inhibitor rHA-Infestin-4: Safe thromboprotection in experimental venous, arterial and foreign surface-induced thrombosis. (2016) Br J Haematol 173:769-78. 10.1111/bjh.13990. 27018425

Pachel C, Mathes D, Arias-Loza AP, Heitzmann W, Nordbeck P, Deppermann C, Lorenz V, Hofmann U, Nieswandt B, Frantz S. Inhibition of Platelet GPVI Protects Against Myocardial Ischemia-Reperfusion Injury. (2016) Arterioscler Thromb Vasc Biol 36:629-35. 10.1161/ATVBAHA.115.305873. 26916731

Stritt S, Nurden P, Turro E, Greene D, Jansen SB, Westbury SK, Petersen R, Astle WJ, Marlin S, Bariana TK, Kostadima M, Lentaigne C, Maiwald S, Papadia S, Kelly AM, Stephens JC, Penkett CJ, Ashford S, Tuna S, Austin S, Bakchoul T, Collins P, Favier R, Lambert MP, Mathias M, Millar CM, Mapeta R, Perry DJ, Schulman S, Simeoni I, Thys C, Consortium B-B, Gomez K, Erber WN, Stirrups K, Rendon A, Bradley JR, Van Geet C, Raymond FL, Laffan MA, Nurden AT, Nieswandt B, Richardson S, Freson K, Ouwehand WH, Mumford AD. A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss. (2016) Blood 127:2903-14. 10.1182/blood-2015-10-675629. 26912466

Wolf K, Braun A, Haining EJ, Tseng YL, Kraft P, Schuhmann MK, Gotru SK, Chen W, Hermanns HM, Stoll G, Lesch KP, Nieswandt B. Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice. (2016) PLoS One 11:e0147664. 10.1371/journal.pone.0147664. 26800051

Mattheij NJ, Braun A, Van Kruchten R, Castoldi E, Pircher J, Baaten CC, Wulling M, Kuijpers MJ, Kohler R, Poole AW, Schreiber R, Vortkamp A, Collins PW, Nieswandt B, Kunzelmann K, Cosemans JM, Heemskerk JW. Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage. (2016) FASEB J 30:727-37. 10.1096/fj.15-280446. 26481309

2015

Kraft P, Schuhmann MK, Fluri F, Lorenz K, Zernecke A, Stoll G, Nieswandt B, Kleinschnitz C. Efficacy and Safety of Platelet Glycoprotein Receptor Blockade in Aged and Comorbid Mice With Acute Experimental Stroke. (2015) Stroke 46:3502-6. 10.1161/STROKEAHA.115.011114. 26486866

Ammar MR, Thahouly T, Hanauer A, Stegner D, Nieswandt B, Vitale N. PLD1 participates in BDNF-induced signalling in cortical neurons. (2015) Sci Rep 5:14778. 10.1038/srep14778. 26437780

Sogkas G, Stegner D, Syed SN, Vogtle T, Rau E, Gewecke B, Schmidt RE, Nieswandt B, Gessner JE. Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation. (2015) Immun Inflamm Dis 3:154-70. 10.1002/iid3.56. 26417434

Alshehri OM, Hughes CE, Montague S, Watson SK, Frampton J, Bender M, Watson SP. Fibrin activates GPVI in human and mouse platelets. (2015) Blood 126:1601-8. 10.1182/blood-2015-04-641654. 26282541

Maurer E, Schaff M, Receveur N, Bourdon C, Mercier L, Nieswandt B, Dubois C, Jandrot-Perrus M, Goetz JG, Lanza F, Gachet C, Mangin PH. Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity. (2015) Thromb Haemost 114:1175-88. 10.1160/TH14-11-0958. 26245230

Verhenne S, Denorme F, Libbrecht S, Vandenbulcke A, Pareyn I, Deckmyn H, Lambrecht A, Nieswandt B, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF. Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice. (2015) Blood 126:1715-22. 10.1182/blood-2015-03-632901. 26209660

Lowe KL, Navarro-Nunez L, Benezech C, Nayar S, Kingston BL, Nieswandt B, Barone F, Watson SP, Buckley CD, Desanti GE. The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state. (2015) Eur J Immunol 45:2484-93. 10.1002/eji.201445314. 26173808

Popp M, Thielmann I, Nieswandt B, Stegner D. Normal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5). (2015) PLoS One 10:e0133429. 10.1371/journal.pone.0133429. 26172113

Gros A, Syvannarath V, Lamrani L, Ollivier V, Loyau S, Goerge T, Nieswandt B, Jandrot-Perrus M, Ho-Tin-Noe B. Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice. (2015) Blood 126:1017-26. 10.1182/blood-2014-12-617159. 26036804

Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, Mangin PH, Jandrot-Perrus M. Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation. (2015) Blood 126:683-91. 10.1182/blood-2015-02-629717. 25977585

Nieswandt B, Stritt S. Megakaryocyte rupture for acute platelet needs. (2015) J Cell Biol 209:327-8. 10.1083/jcb.201504026. 25963815

Westbury SK, Turro E, Greene D, Lentaigne C, Kelly AM, Bariana TK, Simeoni I, Pillois X, Attwood A, Austin S, Jansen SB, Bakchoul T, Crisp-Hihn A, Erber WN, Favier R, Foad N, Gattens M, Jolley JD, Liesner R, Meacham S, Millar CM, Nurden AT, Peerlinck K, Perry DJ, Poudel P, Schulman S, Schulze H, Stephens JC, Furie B, Robinson PN, Van Geet C, Rendon A, Gomez K, Laffan MA, Lambert MP, Nurden P, Ouwehand WH, Richardson S, Mumford AD, Freson K. Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders. (2015) Genome Med 7:36. 10.1186/s13073-015-0151-5. 25949529

Devanathan V, Hagedorn I, Kohler D, Pexa K, Cherpokova D, Kraft P, Singh M, Rosenberger P, Stoll G, Birnbaumer L, Piekorz RP, Beer-Hammer S, Nieswandt B, Nurnberg B. Platelet Gi protein Galphai2 is an essential mediator of thrombo-inflammatory organ damage in mice. (2015) Proc Natl Acad Sci U S A 112:6491-6. 10.1073/pnas.1505887112. 25944935

Sogkas G, Vogtle T, Rau E, Gewecke B, Stegner D, Schmidt RE, Nieswandt B, Gessner JE. Orai1 controls C5a-induced neutrophil recruitment in inflammation. (2015) Eur J Immunol 45:2143-53. 10.1002/eji.201445337. 25912155

Lowe KL, Finney BA, Deppermann C, Hagerling R, Gazit SL, Frampton J, Buckley C, Camerer E, Nieswandt B, Kiefer F, Watson SP. Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. (2015) Blood 125:3769-77. 10.1182/blood-2014-09-603803. 25908104

Crazzolara R, Maurer K, Schulze H, Zieger B, Zustin J, Schulz AS. A new mutation in the KINDLIN-3 gene ablates integrin-dependent leukocyte, platelet, and osteoclast function in a patient with leukocyte adhesion deficiency-III. (2015) Pediatr Blood Cancer 62:1677-9. 10.1002/pbc.25537. 25854317

Schwarzenberger C, Sradnick J, Lerea KM, Goligorsky MS, Nieswandt B, Hugo CP, Hohenstein B. Platelets are relevant mediators of renal injury induced by primary endothelial lesions. (2015) Am J Physiol Renal Physiol 308:F1238-46. 10.1152/ajprenal.00535.2014. 25834071

Lorenz V, Stegner D, Stritt S, Vogtle T, Kiefer F, Witke W, Schymeinsky J, Watson SP, Walzog B, Nieswandt B. Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization. (2015) Blood 125:4069-77. 10.1182/blood-2014-11-611905. 25795918

Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Gopfert C, Meininger I, Diamanti MA, Stegner D, Hafner N, Bottcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Kramer OH, Kamradt T. Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells. (2015) Oncotarget 6:5354-68. 10.18632/oncotarget.3022. 25749030

Bender M, Stritt S, Nurden P, Van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dutting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. (2015) Nat Commun 6:6507. 10.1038/ncomms7507. 25744693

Flierl U, Nero TL, Lim B, Arthur JF, Yao Y, Jung SM, Gitz E, Pollitt AY, Zaldivia MT, Jandrot-Perrus M, Schafer A, Nieswandt B, Andrews RK, Parker MW, Gardiner EE, Peter K. Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators. (2015) J Exp Med 212:129-37. 10.1084/jem.20140391. 25646267

Vogtle T, Cherpokova D, Bender M, Nieswandt B. Targeting platelet receptors in thrombotic and thrombo-inflammatory disorders. (2015) Hamostaseologie 35:235-43. 10.5482/HAMO-14-10-0049. 25634564

Gob E, Reymann S, Langhauser F, Schuhmann MK, Kraft P, Thielmann I, Gobel K, Brede M, Homola G, Solymosi L, Stoll G, Geis C, Meuth SG, Nieswandt B, Kleinschnitz C. Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation. (2015) Ann Neurol 77:784-803. 10.1002/ana.24380. 25628066

Dutting S, Heidenreich J, Cherpokova D, Amin E, Zhang SC, Ahmadian MR, Brakebusch C, Nieswandt B. Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets. (2015) J Thromb Haemost 13:827-38. 10.1111/jth.12861. 25628054

Chandraratne S, Von Bruehl ML, Pagel JI, Stark K, Kleinert E, Konrad I, Farschtschi S, Coletti R, Gartner F, Chillo O, Legate KR, Lorenz M, Rutkowski S, Caballero-Martinez A, Starke R, Tirniceriu A, Pauleikhoff L, Fischer S, Assmann G, Mueller-Hoecker J, Ware J, Nieswandt B, Schaper W, Schulz C, Deindl E, Massberg S. Critical role of platelet glycoprotein ibalpha in arterial remodeling. (2015) Arterioscler Thromb Vasc Biol 35:589-97. 10.1161/ATVBAHA.114.304447. 25550202

Michaelis M, Nieswandt B, Stegner D, Eilers J, Kraft R. STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia. (2015) Glia 63:652-63. 10.1002/glia.22775. 25471906

Teng S, Stegner D, Chen Q, Hongu T, Hasegawa H, Chen L, Kanaho Y, Nieswandt B, Frohman MA, Huang P. Phospholipase D1 facilitates second-phase myoblast fusion and skeletal muscle regeneration. (2015) Mol Biol Cell 26:506-17. 10.1091/mbc.E14-03-0802. 25428992

Subramaniam S, Thielmann I, Morowski M, Pragst I, Sandset PM, Nieswandt B, Etscheid M, Kanse SM. Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP). (2015) Thromb Haemost 113:870-80. 10.1160/TH14-06-0519. 25427855

Stritt S, Wolf K, Lorenz V, Vogtle T, Gupta S, Bosl MR, Nieswandt B. Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice. (2015) Blood 125:219-22. 10.1182/blood-2014-08-597542. 25336629

Schuhmann MK, Kraft P, Stoll G, Lorenz K, Meuth SG, Wiendl H, Nieswandt B, Sparwasser T, Beyersdorf N, Kerkau T, Kleinschnitz C. CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke. (2015) J Cereb Blood Flow Metab 35:6-10. 10.1038/jcbfm.2014.175. 25315859

Cherpokova D, Bender M, Morowski M, Kraft P, Schuhmann MK, Akbar SM, Sultan CS, Hughes CE, Kleinschnitz C, Stoll G, Dragone LL, Watson SP, Tomlinson MG, Nieswandt B. SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice. (2015) Blood 125:185-94. 10.1182/blood-2014-06-580597. 25301707

Andres O, Schulze H, Speer CP. Platelets in neonates: central mediators in haemostasis, antimicrobial defence and inflammation. (2015) Thromb Haemost 113:3-12. 10.1160/th14-05-0476. 25185520

2014

Stritt S, Nieswandt B. In vitro platelets in sight. (2014) Blood 124:1849-50. 10.1182/blood-2014-08-592493. 25606626

Hofmann S, Braun A, Pozgaj R, Morowski M, Vogtle T, Nieswandt B. Mice lacking the SLAM family member CD84 display unaltered platelet function in hemostasis and thrombosis. (2014) PLoS One 9:e115306. 10.1371/journal.pone.0115306. 25551754

Streif W, Knöfler R, Eberl W, Andres O, Bakchoul T, Bergmann F, Beutel K, Dittmer R, Gehrisch S, Gottstein S, Halimeh S, Haselböck J, Hassenpflug WA, Heine S, Holzhauer S, King S, Kirchmaier CM, Krause M, Kreuz W, Lösche W, Mahnel R, Maurer M, Nimtz-Talaska A, Olivieri M, Rott H, Schambeck Ch M, Schedel A, Schilling FH, Schmugge M, Schneppenheim R, Scholz U, Scholz T, Schulze H, Siegemund A, Strauß G, Sykora KW, Wermes C, Wiegering V, Wieland I, Zieger B, Zotz RB. [Therapy of inherited diseases of platelet function. Interdisciplinary S2K guideline of the Permanent Paediatric Committee of the Society of Thrombosis and Haemostasis Research (GTH e. V.)]. (2014) Hamostaseologie 34:269-75, quiz 276. 10.5482/hamo-2014040001. 25370176

Pollitt AY, Poulter NS, Gitz E, Navarro-Nunez L, Wang YJ, Hughes CE, Thomas SG, Nieswandt B, Douglas MR, Owen DM, Jackson DG, Dustin ML, Watson SP. Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells. (2014) J Biol Chem 289:35695-710. 10.1074/jbc.M114.584284. 25368330

Morowski M, Brachs S, Mielenz D, Nieswandt B, Dutting S. The adaptor protein Swiprosin-1/EFhd2 is dispensable for platelet function in mice. (2014) PLoS One 9:e107139. 10.1371/journal.pone.0107139. 25243606

Bender M, Stritt S, Nurden P, Van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dutting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. (2014) Nat Commun 5:4746. 10.1038/ncomms5746. 25187265

Shida Y, Rydz N, Stegner D, Brown C, Mewburn J, Sponagle K, Danisment O, Crawford B, Vidal B, Hegadorn CA, Pruss CM, Nieswandt B, Lillicrap D. Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and alpha2beta1-mediated collagen binding in thrombus formation. (2014) Blood 124:1799-807. 10.1182/blood-2013-09-521484. 25051961

Kraft P, Drechsler C, Gunreben I, Nieswandt B, Stoll G, Heuschmann PU, Kleinschnitz C. Von Willebrand factor regulation in patients with acute and chronic cerebrovascular disease: a pilot, case-control study. (2014) PLoS One 9:e99851. 10.1371/journal.pone.0099851. 24937073

Stegner D, Haining EJ, Nieswandt B. Targeting glycoprotein VI and the immunoreceptor tyrosine-based activation motif signaling pathway. (2014) Arterioscler Thromb Vasc Biol 34:1615-20. 10.1161/ATVBAHA.114.303408. 24925975

Stritt S, Thielmann I, Dutting S, Stegner D, Nieswandt B. Phospholipase D is a central regulator of collagen I-induced cytoskeletal rearrangement and podosome formation in megakaryocytes. (2014) J Thromb Haemost 12:1364-71. 10.1111/jth.12623. 24909796

Knöfler R, Eberl W, Schulze H, Bakchoul T, Bergmann F, Gehrisch S, Geisen C, Gottstein S, Halimeh S, Harbrecht U, Kappert G, Kirchmaier C, Kehrel B, Lösche W, Krause M, Mahnel R, Meyer O, Pilgrimm AK, Pillitteri D, Rott H, Santoso S, Siegemund A, Schambeck C, Scheer M, Schmugge M, Scholl T, Strauss G, Zieger B, Zotz R, Hermann M, Streif W. [Diagnosis of inherited diseases of platelet function. Interdisciplinary S2K guideline of the Permanent Paediatric Committee of the Society of Thrombosis and Haemostasis Research (GTH e. V.)]. (2014) Hamostaseologie 34:201-12. 10.5482/hamo-13-04-0024. 24903476

Stegner D, Dutting S, Nieswandt B. Mechanistic explanation for platelet contribution to cancer metastasis. (2014) Thromb Res 133 Suppl 2:S149-57. 10.1016/S0049-3848(14)50025-4. 24862136

Burkhardt U, Stegner D, Hattingen E, Beyer S, Nieswandt B, Klein J. Impaired brain development and reduced cognitive function in phospholipase D-deficient mice. (2014) Neurosci Lett 572:48-52. 10.1016/j.neulet.2014.04.052. 24813107

Gobel K, Schuhmann MK, Pankratz S, Stegner D, Herrmann AM, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth SG. Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. (2014) Eur J Immunol 44:2295-305. 10.1002/eji.201344107. 24811005

Denes A, Pradillo JM, Drake C, Sharp A, Warn P, Murray KN, Rohit B, Dockrell DH, Chamberlain J, Casbolt H, Francis S, Martinecz B, Nieswandt B, Rothwell NJ, Allan SM. Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibalpha. (2014) Ann Neurol 75:670-83. 10.1002/ana.24146. 24644058

Suo J, Linke B, Meyer Dos Santos S, Pierre S, Stegner D, Zhang DD, Denis CV, Geisslinger G, Nieswandt B, Scholich K. Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation. (2014) J Leukoc Biol 96:133-42. 10.1189/jlb.3A1213-628R. 24555986

Chen W, Thielmann I, Gupta S, Subramanian H, Stegner D, Van Kruchten R, Dietrich A, Gambaryan S, Heemskerk JW, Hermanns HM, Nieswandt B, Braun A. Orai1-induced store-operated Ca(2+) entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets. (2014) J Thromb Haemost 12:528-39. 10.1111/jth.12525. 24520961

Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML. Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. (2014) J Clin Invest 124:273-84. 10.1172/JCI70422. 24292710

Dutting S, Vogtle T, Morowski M, Schiessl S, Schafer CM, Watson SK, Hughes CE, Ackermann JA, Radtke D, Hermanns HM, Watson SP, Nitschke L, Nieswandt B. Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets. (2014) Circ Res 114:444-453. 10.1161/CIRCRESAHA.114.302670. 24265393

Wegener JW, Loga F, Stegner D, Nieswandt B, Hofmann F. Phospholipase D1 is involved in alpha1-adrenergic contraction of murine vascular smooth muscle. (2014) FASEB J 28:1044-8. 10.1096/fj.13-237925. 24253251

Hillgruber C, Steingraber AK, Poppelmann B, Denis CV, Ware J, Vestweber D, Nieswandt B, Schneider SW, Goerge T. Blocking von Willebrand factor for treatment of cutaneous inflammation. (2014) J Invest Dermatol 134:77-86. 10.1038/jid.2013.292. 23812299

2013

Deppermann C, Nurden P, Nurden AT, Nieswandt B, Stegner D. The Nbeal2(-/-) mouse as a model for the gray platelet syndrome. (2013) Rare Dis 1:e26561. 10.4161/rdis.26561. 25003009

Ammar MR, Humeau Y, Hanauer A, Nieswandt B, Bader MF, Vitale N. The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of phospholipase D1 (PLD1) and synthesis of phosphatidic acid. (2013) J Neurosci 33:19470-9. 10.1523/JNEUROSCI.2283-13.2013. 24336713

Kraft P, Gob E, Schuhmann MK, Gobel K, Deppermann C, Thielmann I, Herrmann AM, Lorenz K, Brede M, Stoll G, Meuth SG, Nieswandt B, Pfeilschifter W, Kleinschnitz C. FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection. (2013) Stroke 44:3202-10. 10.1161/STROKEAHA.113.002880. 24029635

Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, Mcdaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, Mcgee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, Mcever RP, Chen H, Kahn ML, Xia L. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. (2013) Nature 502:105-9. 10.1038/nature12501. 23995678

Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha Ou Maati H, Bobak N, Gobel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, Meuth SG. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. (2013) Nat Med 19:1161-5. 10.1038/nm.3303. 23933981

Lachmann N, Todorova K, Schulze H, Schönemann C. Luminex(®) and its applications for solid organ transplantation, hematopoietic stem cell transplantation, and transfusion. (2013) Transfus Med Hemother 40:182-9. 10.1159/000351459. 23922543

Stegner D, Thielmann I, Kraft P, Frohman MA, Stoll G, Nieswandt B. Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report. (2013) Arterioscler Thromb Vasc Biol 33:2212-7. 10.1161/ATVBAHA.113.302030. 23868933

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vogtle T, Kleinschnitz C, Dutting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B. Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice. (2013) J Clin Invest 123:3331-42. 10.1172/JCI69210. 23863626

Pleines I, Dutting S, Cherpokova D, Eckly A, Meyer I, Morowski M, Krohne G, Schulze H, Gachet C, Debili N, Brakebusch C, Nieswandt B. Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. (2013) Blood 122:3178-87. 10.1182/blood-2013-03-487942. 23861250

Stetter C, Hirschberg M, Nieswandt B, Ernestus RI, Heckmann M, Siren AL. An experimental protocol for in vivo imaging of neuronal structural plasticity with 2-photon microscopy in mice. (2013) Exp Transl Stroke Med 5:9. 10.1186/2040-7378-5-9. 23842538

Schaff M, Tang C, Maurer E, Bourdon C, Receveur N, Eckly A, Hechler B, Arnold C, De Arcangelis A, Nieswandt B, Denis CV, Lefebvre O, Georges-Labouesse E, Gachet C, Lanza F, Mangin PH. Integrin alpha6beta1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis. (2013) Circulation 128:541-52. 10.1161/CIRCULATIONAHA.112.000799. 23797810

Nieswandt B, Stoll G. (Dis)solving the stroke problem by vWF inhibition?. (2013) Blood 121:4972-4. 10.1182/blood-2013-05-498725. 23788023

Timofeev O, Schlereth K, Wanzel M, Braun A, Nieswandt B, Pagenstecher A, Rosenwald A, Elsasser HP, Stiewe T. p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. (2013) Cell Rep 3:1512-25. 10.1016/j.celrep.2013.04.008. 23665223

Stegner D, Deppermann C, Kraft P, Morowski M, Kleinschnitz C, Stoll G, Nieswandt B. Munc13-4-mediated secretion is essential for infarct progression but not intracranial hemostasis in acute stroke. (2013) J Thromb Haemost 11:1430-3. 10.1111/jth.12293. 23659589

Morowski M, Vogtle T, Kraft P, Kleinschnitz C, Stoll G, Nieswandt B. Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice. (2013) Blood 121:4938-47. 10.1182/blood-2012-10-461459. 23584880

Pfeiffer V, Gotz R, Xiang C, Camarero G, Braun A, Zhang Y, Blum R, Heinsen H, Nieswandt B, Rapp UR. Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum. (2013) PLoS One 8:e58259. 10.1371/journal.pone.0058259. 23505473

Bender M, May F, Lorenz V, Thielmann I, Hagedorn I, Finney BA, Vogtle T, Remer K, Braun A, Bosl M, Watson SP, Nieswandt B. Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. (2013) Arterioscler Thromb Vasc Biol 33:926-34. 10.1161/ATVBAHA.112.300672. 23448972

Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Gobel K, Schuhmann MK, Langhauser F, Helluy X, Schwarz T, Bittner S, Mayer CT, Brede M, Varallyay C, Pham M, Bendszus M, Jakob P, Magnus T, Meuth SG, Iwakura Y, Zernecke A, Sparwasser T, Nieswandt B, Stoll G, Wiendl H. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. (2013) Blood 121:679-91. 10.1182/blood-2012-04-426734. 23160472

Frantz S, Hofmann U, Fraccarollo D, Schafer A, Kranepuhl S, Hagedorn I, Nieswandt B, Nahrendorf M, Wagner H, Bayer B, Pachel C, Schon MP, Kneitz S, Bobinger T, Weidemann F, Ertl G, Bauersachs J. Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction. (2013) FASEB J 27:871-81. 10.1096/fj.12-214049. 23159933

Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE, Jr., Hartwig JH, Walter U. Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis. (2013) Exp Hematol 41:91-101.e4. 10.1016/j.exphem.2012.09.001. 22981933

2012

Stegner D, Nieswandt B. Size does matter: VWF in MI. (2012) Blood 120:5096-7. 10.1182/blood-2012-09-452813. 23258899

Chen Q, Hongu T, Sato T, Zhang Y, Ali W, Cavallo JA, Van Der Velden A, Tian H, Di Paolo G, Nieswandt B, Kanaho Y, Frohman MA. Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. (2012) Sci Signal 5:ra79. 10.1126/scisignal.2003257. 23131846

Mazharian A, Wang YJ, Mori J, Bem D, Finney B, Heising S, Gissen P, White JG, Berndt MC, Gardiner EE, Nieswandt B, Douglas MR, Campbell RD, Watson SP, Senis YA. Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. (2012) Sci Signal 5:ra78. 10.1126/scisignal.2002936. 23112346

Hofmann S, Vogtle T, Bender M, Rose-John S, Nieswandt B. The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets. (2012) J Thromb Haemost 10:2581-92. 10.1111/jth.12013. 23025437

Thielmann I, Stegner D, Kraft P, Hagedorn I, Krohne G, Kleinschnitz C, Stoll G, Nieswandt B. Redundant functions of phospholipases D1 and D2 in platelet alpha-granule release. (2012) J Thromb Haemost 10:2361-72. 10.1111/j.1538-7836.2012.04924.x. 22974101

Gupta S, Braun A, Morowski M, Premsler T, Bender M, Nagy Z, Sickmann A, Hermanns HM, Bosl M, Nieswandt B. CLP36 is a negative regulator of glycoprotein VI signaling in platelets. (2012) Circ Res 111:1410-20. 10.1161/CIRCRESAHA.112.264754. 22955732

Wohlleber D, Kashkar H, Gartner K, Frings MK, Odenthal M, Hegenbarth S, Borner C, Arnold B, Hammerling G, Nieswandt B, Van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Kronke M, Knolle PA. TNF-induced target cell killing by CTL activated through cross-presentation. (2012) Cell Rep 2:478-87. 10.1016/j.celrep.2012.08.001. 22939982

Langhauser F, Gob E, Kraft P, Geis C, Schmitt J, Brede M, Gobel K, Helluy X, Pham M, Bendszus M, Jakob P, Stoll G, Meuth SG, Nieswandt B, Mccrae KR, Kleinschnitz C. Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. (2012) Blood 120:4082-92. 10.1182/blood-2012-06-440057. 22936662

Meyer I, Kunert S, Schwiebert S, Hagedorn I, Italiano JE, Jr., Dutting S, Nieswandt B, Bachmann S, Schulze H. Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10. (2012) Blood 120:3594-602. 10.1182/blood-2012-01-401737. 22936655

Meyer I, Kunert S, Schwiebert S, Hagedorn I, Italiano JE, Jr., Dütting S, Nieswandt B, Bachmann S, Schulze H. Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10. (2012) Blood 120:3594-602. 10.1182/blood-2012-01-401737. 22936655

Dutting S, Bender M, Nieswandt B. Platelet GPVI: a target for antithrombotic therapy?!. (2012) Trends Pharmacol Sci 33:583-90. 10.1016/j.tips.2012.07.004. 22901552

Schonberger T, Ziegler M, Borst O, Konrad I, Nieswandt B, Massberg S, Ochmann C, Jurgens T, Seizer P, Langer H, Munch G, Ungerer M, Preissner KT, Elvers M, Gawaz M. The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice. (2012) Am J Physiol Cell Physiol 303:C757-66. 10.1152/ajpcell.00060.2012. 22814400

Nieswandt B. Platelets guide lymphocytes to vascular injury sites. (2012) Thromb Haemost 108:207. 10.1160/TH12-07-0450. 22782462

Heydenreich N, Nolte MW, Gob E, Langhauser F, Hofmeister M, Kraft P, Albert-Weissenberger C, Brede M, Varallyay C, Gobel K, Meuth SG, Nieswandt B, Dickneite G, Stoll G, Kleinschnitz C. C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms. (2012) Stroke 43:2457-67. 10.1161/STROKEAHA.112.660340. 22744646

Konigsberger S, Prodohl J, Stegner D, Weis V, Andreas M, Stehling M, Schumacher T, Bohmer R, Thielmann I, Van Eeuwijk JM, Nieswandt B, Kiefer F. Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state. (2012) EMBO J 31:3363-74. 10.1038/emboj.2012.169. 22728826

Van Kruchten R, Braun A, Feijge MA, Kuijpers MJ, Rivera-Galdos R, Kraft P, Stoll G, Kleinschnitz C, Bevers EM, Nieswandt B, Heemskerk JW. Antithrombotic potential of blockers of store-operated calcium channels in platelets. (2012) Arterioscler Thromb Vasc Biol 32:1717-23. 10.1161/ATVBAHA.111.243907. 22580895

Dramane G, Abdoul-Azize S, Hichami A, Vogtle T, Akpona S, Chouabe C, Sadou H, Nieswandt B, Besnard P, Khan NA. STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice. (2012) J Clin Invest 122:2267-82. 10.1172/JCI59953. 22546859

Langer HF, Choi EY, Zhou H, Schleicher R, Chung KJ, Tang Z, Gobel K, Bdeir K, Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, Rose JW, Burns JB, Hill KE, Qu H, Zhang Y, Lehrmann E, Becker KG, Wang Y, Simon DI, Nieswandt B, Lambris JD, Li X, Meuth SG, Kubes P, Chavakis T. Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. (2012) Circ Res 110:1202-10. 10.1161/CIRCRESAHA.111.256370. 22456181

Albers CA, Paul DS, Schulze H, Freson K, Stephens JC, Smethurst PA, Jolley JD, Cvejic A, Kostadima M, Bertone P, Breuning MH, Debili N, Deloukas P, Favier R, Fiedler J, Hobbs CM, Huang N, Hurles ME, Kiddle G, Krapels I, Nurden P, Ruivenkamp CA, Sambrook JG, Smith K, Stemple DL, Strauss G, Thys C, Van Geet C, Newbury-Ecob R, Ouwehand WH, Ghevaert C. Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome. (2012) Nat Genet 44:435-9, s1-2. 10.1038/ng.1083. 22366785

Dutting S, Nieswandt B. Better safe than sorry: glycoprotein VI dimerization as a novel checkpoint and early biomarker of platelet activation. (2012) Arterioscler Thromb Vasc Biol 32:552-3. 10.1161/ATVBAHA.111.243402. 22345591

Sodero AO, Vriens J, Ghosh D, Stegner D, Brachet A, Pallotto M, Sassoe-Pognetto M, Brouwers JF, Helms JB, Nieswandt B, Voets T, Dotti CG. Cholesterol loss during glutamate-mediated excitotoxicity. (2012) EMBO J 31:1764-73. 10.1038/emboj.2012.31. 22343944

Bender M. High VWF, low ADAMTS13 puts women at risk. (2012) Blood 119:1329-30. 10.1182/blood-2011-12-395889. 22323407

Ponnuswamy P, Schrottle A, Ostermeier E, Gruner S, Huang PL, Ertl G, Hoffmann U, Nieswandt B, Kuhlencordt PJ. eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. (2012) PLoS One 7:e30193. 10.1371/journal.pone.0030193. 22291917

Ramanathan G, Gupta S, Thielmann I, Pleines I, Varga-Szabo D, May F, Mannhalter C, Dietrich A, Nieswandt B, Braun A. Defective diacylglycerol-induced Ca2+ entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets. (2012) J Thromb Haemost 10:419-29. 10.1111/j.1538-7836.2011.04596.x. 22176814

Schulze H. Culture of murine megakaryocytes and platelets from fetal liver and bone marrow. (2012) Methods Mol Biol 788:193-203. 10.1007/978-1-61779-307-3_14. 22130709

Braeuninger S, Kleinschnitz C, Nieswandt B, Stoll G. Focal cerebral ischemia. (2012) Methods Mol Biol 788:29-42. 10.1007/978-1-61779-307-3_3. 22130698

Lonsdorf AS, Kramer BF, Fahrleitner M, Schonberger T, Gnerlich S, Ring S, Gehring S, Schneider SW, Kruhlak MJ, Meuth SG, Nieswandt B, Gawaz M, Enk AH, Langer HF. Engagement of alphaIIbbeta3 (GPIIb/IIIa) with alphanubeta3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis. (2012) J Biol Chem 287:2168-78. 10.1074/jbc.M111.269811. 22102277

Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, Van Hengel J, Offermanns S, Krohne G, Kleinschnitz C, Brakebusch C, Nieswandt B. Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. (2012) Blood 119:1054-63. 10.1182/blood-2011-08-372193. 22045984

Fiedler J, Strauss G, Wannack M, Schwiebert S, Seidel K, Henning K, Klopocki E, Schmugge M, Gaedicke G, Schulze H. Two patterns of thrombopoietin signaling suggest no coupling between platelet production and thrombopoietin reactivity in thrombocytopenia-absent radii syndrome. (2012) Haematologica 97:73-81. 10.3324/haematol.2011.049619. 21933853

Pham M, Stoll G, Nieswandt B, Bendszus M, Kleinschnitz C. Blood coagulation factor XII--a neglected player in stroke pathophysiology. (2012) J Mol Med (Berl) 90:119-26. 10.1007/s00109-011-0812-9. 21909687

Kraft P, Nieswandt B, Stoll G, Kleinschnitz C. [Acute ischemic stroke. New approaches to antithrombotic treatment]. (2012) Nervenarzt 83:435-49. 10.1007/s00115-011-3368-6. 21901539

2011

Schulze H, Gaedicke G. Immune thrombocytopenia in children and adults: what's the same, what's different?. (2011) Haematologica 96:1739-41. 10.3324/haematol.2011.055830. 22147771

Verschoor A, Neuenhahn M, Navarini AA, Graef P, Plaumann A, Seidlmeier A, Nieswandt B, Massberg S, Zinkernagel RM, Hengartner H, Busch DH. A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha+ dendritic cells depends on glycoprotein GPIb and complement C3. (2011) Nat Immunol 12:1194-201. 10.1038/ni.2140. 22037602

Strauss G, Vollert C, Von Stackelberg A, Weimann A, Gaedicke G, Schulze H. Immature platelet count: a simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia. (2011) Pediatr Blood Cancer 57:641-7. 10.1002/pbc.22907. 21826780

Hulot JS, Fauconnier J, Ramanujam D, Chaanine A, Aubart F, Sassi Y, Merkle S, Cazorla O, Ouille A, Dupuis M, Hadri L, Jeong D, Muhlstedt S, Schmitt J, Braun A, Benard L, Saliba Y, Laggerbauer B, Nieswandt B, Lacampagne A, Hajjar RJ, Lompre AM, Engelhardt S. Critical role for stromal interaction molecule 1 in cardiac hypertrophy. (2011) Circulation 124:796-805. 10.1161/CIRCULATIONAHA.111.031229. 21810664

Nieswandt B, Pleines I, Bender M. Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke. (2011) J Thromb Haemost 9 Suppl 1:92-104. 10.1111/j.1538-7836.2011.04361.x. 21781245

Nieswandt B, Kleinschnitz C, Stoll G. Ischaemic stroke: a thrombo-inflammatory disease?. (2011) J Physiol 589:4115-23. 10.1113/jphysiol.2011.212886. 21768262

Braun A, Vogtle T, Varga-Szabo D, Nieswandt B. STIM and Orai in hemostasis and thrombosis. (2011) Front Biosci (Landmark Ed) 16:2144-60. 10.2741/3844. 21622167

Varga-Szabo D, Braun A, Nieswandt B. STIM and Orai in platelet function. (2011) Cell Calcium 50:270-8. 10.1016/j.ceca.2011.04.002. 21616531

Bender M, Hagedorn I, Nieswandt B. Genetic and antibody-induced glycoprotein VI deficiency equally protects mice from mechanically and FeCl(3) -induced thrombosis. (2011) J Thromb Haemost 9:1423-6. 10.1111/j.1538-7836.2011.04328.x. 21535392

Pham M, Helluy X, Kleinschnitz C, Kraft P, Bartsch AJ, Jakob P, Nieswandt B, Bendszus M, Stoll G. Sustained reperfusion after blockade of glycoprotein-receptor-Ib in focal cerebral ischemia: an MRI study at 17.6 Tesla. (2011) PLoS One 6:e18386. 10.1371/journal.pone.0018386. 21483769

Nieswandt B, Heemskerk JW. Dividing VI by X(a). (2011) Blood 117:3704-5. 10.1182/blood-2011-02-332742. 21474679

Schulz C, Von Bruhl ML, Barocke V, Cullen P, Mayer K, Okrojek R, Steinhart A, Ahmad Z, Kremmer E, Nieswandt B, Frampton J, Massberg S, Schmidt R. EMMPRIN (CD147/basigin) mediates platelet-monocyte interactions in vivo and augments monocyte recruitment to the vascular wall. (2011) J Thromb Haemost 9:1007-19. 10.1111/j.1538-7836.2011.04235.x. 21320284

Nieswandt B, Stoll G. Sugar rush bleeds the brain. (2011) Nat Med 17:161-2. 10.1038/nm0211-161. 21297607

Stegner D, Nieswandt B. Platelet receptor signaling in thrombus formation. (2011) J Mol Med (Berl) 89:109-21. 10.1007/s00109-010-0691-5. 21058007

2010

Stoll G, Kleinschnitz C, Nieswandt B. Combating innate inflammation: a new paradigm for acute treatment of stroke?. (2010) Ann N Y Acad Sci 1207:149-54. 10.1111/j.1749-6632.2010.05730.x. 20955438

Petri B, Broermann A, Li H, Khandoga AG, Zarbock A, Krombach F, Goerge T, Schneider SW, Jones C, Nieswandt B, Wild MK, Vestweber D. von Willebrand factor promotes leukocyte extravasation. (2010) Blood 116:4712-9. 10.1182/blood-2010-03-276311. 20716766

Hagedorn I, Vogtle T, Nieswandt B. Arterial thrombus formation. Novel mechanisms and targets. (2010) Hamostaseologie 30:127-35. 20680230

Stoll G, Kleinschnitz C, Nieswandt B. The role of glycoprotein Ibalpha and von Willebrand factor interaction in stroke development. (2010) Hamostaseologie 30:136-8. 20680228

Lütteke N, Raftery MJ, Lalwani P, Lee MH, Giese T, Voigt S, Bannert N, Schulze H, Krüger DH, Schönrich G. Switch to high-level virus replication and HLA class I upregulation in differentiating megakaryocytic cells after infection with pathogenic hantavirus. (2010) Virology 405:70-80. 10.1016/j.virol.2010.05.028. 20673746

Bender M, Hofmann S, Stegner D, Chalaris A, Bosl M, Braun A, Scheller J, Rose-John S, Nieswandt B. Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. (2010) Blood 116:3347-55. 10.1182/blood-2010-06-289108. 20644114

De Meyer SF, Schwarz T, Deckmyn H, Denis CV, Nieswandt B, Stoll G, Vanhoorelbeke K, Kleinschnitz C. Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report. (2010) Arterioscler Thromb Vasc Biol 30:1949-51. 10.1161/ATVBAHA.110.208918. 20616311

Winter O, Moser K, Mohr E, Zotos D, Kaminski H, Szyska M, Roth K, Wong DM, Dame C, Tarlinton DM, Schulze H, Maclennan IC, Manz RA. Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow. (2010) Blood 116:1867-75. 10.1182/blood-2009-12-259457. 20538807

Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. (2010) Blood 116:1767-75. 10.1182/blood-2010-03-274340. 20530287

Gilio K, Van Kruchten R, Braun A, Berna-Erro A, Feijge MA, Stegner D, Van Der Meijden PE, Kuijpers MJ, Varga-Szabo D, Heemskerk JW, Nieswandt B. Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation. (2010) J Biol Chem 285:23629-38. 10.1074/jbc.M110.108696. 20519511

Bultmann A, Li Z, Wagner S, Peluso M, Schonberger T, Weis C, Konrad I, Stellos K, Massberg S, Nieswandt B, Gawaz M, Ungerer M, Munch G. Impact of glycoprotein VI and platelet adhesion on atherosclerosis--a possible role of fibronectin. (2010) J Mol Cell Cardiol 49:532-42. 10.1016/j.yjmcc.2010.04.009. 20430036

Hagedorn I, Schmidbauer S, Pleines I, Kleinschnitz C, Kronthaler U, Stoll G, Dickneite G, Nieswandt B. Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding. (2010) Circulation 121:1510-7. 10.1161/CIRCULATIONAHA.109.924761. 20308613

Elvers M, Pozgaj R, Pleines I, May F, Kuijpers MJ, Heemskerk JM, Yu P, Nieswandt B. Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2. (2010) J Thromb Haemost 8:1353-63. 10.1111/j.1538-7836.2010.03838.x. 20230420

Jurk K, Schulz AS, Kehrel BE, Räpple D, Schulze H, Möbest D, Friedrich WW, Omran H, Deak E, Henschler R, Scheele JS, Zieger B. Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3. (2010) Thromb Haemost 103:1053-64. 10.1160/th09-10-0689. 20216991

Kleinschnitz C, Schwab N, Kraft P, Hagedorn I, Dreykluft A, Schwarz T, Austinat M, Nieswandt B, Wiendl H, Stoll G. Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. (2010) Blood 115:3835-42. 10.1182/blood-2009-10-249078. 20215643

Nieswandt B, Stoll G. The smaller, the better: VWF in stroke. (2010) Blood 115:1477-8. 10.1182/blood-2009-12-255000. 20185592

Pleines I, Eckly A, Elvers M, Hagedorn I, Eliautou S, Bender M, Wu X, Lanza F, Gachet C, Brakebusch C, Nieswandt B. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. (2010) Blood 115:3364-73. 10.1182/blood-2009-09-242271. 20139097

Elvers M, Stegner D, Hagedorn I, Kleinschnitz C, Braun A, Kuijpers ME, Boesl M, Chen Q, Heemskerk JW, Stoll G, Frohman MA, Nieswandt B. Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. (2010) Sci Signal 3:ra1. 10.1126/scisignal.2000551. 20051593

Schuhmann MK, Stegner D, Berna-Erro A, Bittner S, Braun A, Kleinschnitz C, Stoll G, Wiendl H, Meuth SG, Nieswandt B. Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation. (2010) J Immunol 184:1536-42. 10.4049/jimmunol.0902161. 20028655

Pham M, Kleinschnitz C, Helluy X, Bartsch AJ, Austinat M, Behr VC, Renne T, Nieswandt B, Stoll G, Bendszus M. Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI. (2010) Neuroimage 49:2907-14. 10.1016/j.neuroimage.2009.11.061. 19958838

Erpenbeck L, Nieswandt B, Schon M, Pozgajova M, Schon MP. Inhibition of platelet GPIb alpha and promotion of melanoma metastasis. (2010) J Invest Dermatol 130:576-86. 10.1038/jid.2009.278. 19727118

2009

Berna-Erro A, Braun A, Kraft R, Kleinschnitz C, Schuhmann MK, Stegner D, Wultsch T, Eilers J, Meuth SG, Stoll G, Nieswandt B. STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. (2009) Sci Signal 2:ra67. 10.1126/scisignal.2000522. 19843959

Kunert S, Meyer I, Fleischhauer S, Wannack M, Fiedler J, Shivdasani RA, Schulze H. The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. (2009) Blood 114:5532-40. 10.1182/blood-2009-04-216804. 19801445

Syed SN, Konrad S, Wiege K, Nieswandt B, Nimmerjahn F, Schmidt RE, Gessner JE. Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a. (2009) Eur J Immunol 39:3343-56. 10.1002/eji.200939884. 19795417

May F, Hagedorn I, Pleines I, Bender M, Vogtle T, Eble J, Elvers M, Nieswandt B. CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis. (2009) Blood 114:3464-72. 10.1182/blood-2009-05-222273. 19641185

Nieswandt B, Varga-Szabo D, Elvers M. Integrins in platelet activation. (2009) J Thromb Haemost 7 Suppl 1:206-9. 10.1111/j.1538-7836.2009.03370.x. 19630801

Ponnuswamy P, Ostermeier E, Schrottle A, Chen J, Huang PL, Ertl G, Nieswandt B, Kuhlencordt PJ. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. (2009) Am J Pathol 174:2400-10. 10.2353/ajpath.2009.080730. 19465644

Varga-Szabo D, Braun A, Nieswandt B. Calcium signaling in platelets. (2009) J Thromb Haemost 7:1057-66. 10.1111/j.1538-7836.2009.03455.x. 19422456

Beyersdorf N, Braun A, Vogtle T, Varga-Szabo D, Galdos RR, Kissler S, Kerkau T, Nieswandt B. STIM1-independent T cell development and effector function in vivo. (2009) J Immunol 182:3390-7. 10.4049/jimmunol.0802888. 19265116

Kleinschnitz C, De Meyer SF, Schwarz T, Austinat M, Vanhoorelbeke K, Nieswandt B, Deckmyn H, Stoll G. Deficiency of von Willebrand factor protects mice from ischemic stroke. (2009) Blood 113:3600-3. 10.1182/blood-2008-09-180695. 19182208

Abele S, Spriewald BM, Ramsperger-Gleixner M, Wollin M, Hiemann NE, Nieswandt B, Weyand M, Ensminger SM. Attenuation of transplant arteriosclerosis with clopidogrel is associated with a reduction of infiltrating dendritic cells and macrophages in murine aortic allografts. (2009) Transplantation 87:207-16. 10.1097/TP.0b013e3181938913. 19155974

Schroder J, Lullmann-Rauch R, Himmerkus N, Pleines I, Nieswandt B, Orinska Z, Koch-Nolte F, Schroder B, Bleich M, Saftig P. Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. (2009) Mol Cell Biol 29:1083-94. 10.1128/MCB.01163-08. 19075008

Wong C, Liu Y, Yip J, Chand R, Wee JL, Oates L, Nieswandt B, Reheman A, Ni H, Beauchemin N, Jackson DE. CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. (2009) Blood 113:1818-28. 10.1182/blood-2008-06-165043. 19008452

Kuijpers MJ, Gilio K, Reitsma S, Nergiz-Unal R, Prinzen L, Heeneman S, Lutgens E, Van Zandvoort MA, Nieswandt B, Egbrink MG, Heemskerk JW. Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model. (2009) J Thromb Haemost 7:152-61. 10.1111/j.1538-7836.2008.03186.x. 18983512

Braun A, Gessner JE, Varga-Szabo D, Syed SN, Konrad S, Stegner D, Vogtle T, Schmidt RE, Nieswandt B. STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation. (2009) Blood 113:1097-104. 10.1182/blood-2008-05-158477. 18941110

Braun A, Varga-Szabo D, Kleinschnitz C, Pleines I, Bender M, Austinat M, Bosl M, Stoll G, Nieswandt B. Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. (2009) Blood 113:2056-63. 10.1182/blood-2008-07-171611. 18832659

Pleines I, Elvers M, Strehl A, Pozgajova M, Varga-Szabo D, May F, Chrostek-Grashoff A, Brakebusch C, Nieswandt B. Rac1 is essential for phospholipase C-gamma2 activation in platelets. (2009) Pflugers Arch 457:1173-85. 10.1007/s00424-008-0573-7. 18704487

2008

Stoll G, Kleinschnitz C, Nieswandt B. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. (2008) Blood 112:3555-62. 10.1182/blood-2008-04-144758. 18676880

Varga-Szabo D, Braun A, Kleinschnitz C, Bender M, Pleines I, Pham M, Renne T, Stoll G, Nieswandt B. The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. (2008) J Exp Med 205:1583-91. 10.1084/jem.20080302. 18559454

Varga-Szabo D, Authi KS, Braun A, Bender M, Ambily A, Hassock SR, Gudermann T, Dietrich A, Nieswandt B. Store-operated Ca(2+) entry in platelets occurs independently of transient receptor potential (TRP) C1. (2008) Pflugers Arch 457:377-87. 10.1007/s00424-008-0531-4. 18546016

Nieswandt B. How do platelets prevent bleeding?. (2008) Blood 111:4835. 10.1182/blood-2008-02-139006. 18467603

Geng H, Zhang H, Zhang W, Nieswandt B, Bray PF, Leng X. Transdermal 17-beta estradiol replacement therapy reduces megakaryocyte GPVI expression. (2008) Thromb Res 123:93-9. 10.1016/j.thromres.2008.03.014. 18448154

Kleinschnitz C, Braeuninger S, Pham M, Austinat M, Nolte I, Renne T, Nieswandt B, Bendszus M, Stoll G. Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosis. (2008) Stroke 39:1262-8. 10.1161/STROKEAHA.107.496448. 18292385

Moser M, Nieswandt B, Ussar S, Pozgajova M, Fassler R. Kindlin-3 is essential for integrin activation and platelet aggregation. (2008) Nat Med 14:325-30. 10.1038/nm1722. 18278053

Elzey BD, Schmidt NW, Crist SA, Kresowik TP, Harty JT, Nieswandt B, Ratliff TL. Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. (2008) Blood 111:3684-91. 10.1182/blood-2007-05-091728. 18256321

Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA, Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH, Italiano JE, Jr.. Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. (2008) Blood 111:4605-16. 10.1182/blood-2007-10-118844. 18230754

Varga-Szabo D, Pleines I, Nieswandt B. Cell adhesion mechanisms in platelets. (2008) Arterioscler Thromb Vasc Biol 28:403-12. 10.1161/ATVBAHA.107.150474. 18174460

2007

Nieswandt B, Moser M, Pleines I, Varga-Szabo D, Monkley S, Critchley D, Fassler R. Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. (2007) J Exp Med 204:3113-8. 10.1084/jem.20071827. 18086864

Kuijpers MJ, Pozgajova M, Cosemans JM, Munnix IC, Eckes B, Nieswandt B, Heemskerk JW. Role of murine integrin alpha2beta1 in thrombus stabilization and embolization: contribution of thromboxane A2. (2007) Thromb Haemost 98:1072-80. 18000613

Grosse J, Braun A, Varga-Szabo D, Beyersdorf N, Schneider B, Zeitlmann L, Hanke P, Schropp P, Muhlstedt S, Zorn C, Huber M, Schmittwolf C, Jagla W, Yu P, Kerkau T, Schulze H, Nehls M, Nieswandt B. An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. (2007) J Clin Invest 117:3540-50. 10.1172/JCI32312. 17965774

Grosse J, Braun A, Varga-Szabo D, Beyersdorf N, Schneider B, Zeitlmann L, Hanke P, Schropp P, Mühlstedt S, Zorn C, Huber M, Schmittwolf C, Jagla W, Yu P, Kerkau T, Schulze H, Nehls M, Nieswandt B. An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. (2007) J Clin Invest 117:3540-50. 10.1172/jci32312. 17965774

Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE, Jr., Shivdasani RA, Von Andrian UH. Dynamic visualization of thrombopoiesis within bone marrow. (2007) Science 317:1767-70. 10.1126/science.1146304. 17885137

Oostingh GJ, Pozgajova M, Ludwig RJ, Krahn T, Boehncke WH, Nieswandt B, Schon MP. Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functions. (2007) Haematologica 92:502-12. 10.3324/haematol.10741. 17488661

Kleinschnitz C, Pozgajova M, Pham M, Bendszus M, Nieswandt B, Stoll G. Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. (2007) Circulation 115:2323-30. 10.1161/CIRCULATIONAHA.107.691279. 17438148

Sachs UJ, Nieswandt B. In vivo thrombus formation in murine models. (2007) Circ Res 100:979-91. 10.1161/01.RES.0000261936.85776.5f. 17431199

Rabie T, Varga-Szabo D, Bender M, Pozgaj R, Lanza F, Saito T, Watson SP, Nieswandt B. Diverging signaling events control the pathway of GPVI down-regulation in vivo. (2007) Blood 110:529-35. 10.1182/blood-2006-11-058107. 17374738

Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers HH, Ullmann R, Horn D, Mundlos S. Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome. (2007) Am J Hum Genet 80:232-40. 10.1086/510919. 17236129

Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, Depinho RA, Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. (2007) Genes Dev 21:98-111. 10.1101/gad.1480007. 17210792

Strehl A, Munnix IC, Kuijpers MJ, Van Der Meijden PE, Cosemans JM, Feijge MA, Nieswandt B, Heemskerk JW. Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets. (2007) J Biol Chem 282:7046-55. 10.1074/jbc.M611367200. 17210570

Oostingh GJ, Ludwig RJ, Enders S, Gruner S, Harms G, Boehncke WH, Nieswandt B, Tauber R, Schon MP. Diminished lymphocyte adhesion and alleviation of allergic responses by small-molecule- or antibody-mediated inhibition of L-selectin functions. (2007) J Invest Dermatol 127:90-7. 10.1038/sj.jid.5700504. 16902419

2006

Gaedicke G, Schulze H. Some unsettled questions in childhood thrombocytopenia caused by immunologic platelet destruction (acute and chronic ITP). (2006) Pediatr Blood Cancer 47:668-70. 10.1002/pbc.20997. 16933247

Webster ML, Sayeh E, Crow M, Chen P, Nieswandt B, Freedman J, Ni H. Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies. (2006) Blood 108:943-6. 10.1182/blood-2005-06-009761. 16861348

Schulte V, Reusch HP, Pozgajova M, Varga-Szabo D, Gachet C, Nieswandt B. Two-phase antithrombotic protection after anti-glycoprotein VI treatment in mice. (2006) Arterioscler Thromb Vasc Biol 26:1640-7. 10.1161/01.ATV.0000225697.98093.ed. 16675723

Kleinschnitz C, Stoll G, Bendszus M, Schuh K, Pauer HU, Burfeind P, Renne C, Gailani D, Nieswandt B, Renne T. Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. (2006) J Exp Med 203:513-8. 10.1084/jem.20052458. 16533887

Pozgajova M, Sachs UJ, Hein L, Nieswandt B. Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor. (2006) Blood 108:510-4. 10.1182/blood-2005-12-4835. 16507775

Johne J, Blume C, Benz PM, Pozgajova M, Ullrich M, Schuh K, Nieswandt B, Walter U, Renne T. Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma. (2006) Biol Chem 387:173-8. 10.1515/BC.2006.023. 16497149

Renne T, Nieswandt B, Gailani D. The intrinsic pathway of coagulation is essential for thrombus stability in mice. (2006) Blood Cells Mol Dis 36:148-51. 10.1016/j.bcmd.2005.12.014. 16466946

Schulze H, Korpal M, Hurov J, Kim SW, Zhang J, Cantley LC, Graf T, Shivdasani RA. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. (2006) Blood 107:3868-75. 10.1182/blood-2005-07-2755. 16434494

2005

Dittrich M, Birschmann I, Stuhlfelder C, Sickmann A, Herterich S, Nieswandt B, Walter U, Dandekar T. Understanding platelets. Lessons from proteomics, genomics and promises from network analysis. (2005) Thromb Haemost 94:916-25. 10.1160/TH05-02-0121. 16363231

Munnix IC, Strehl A, Kuijpers MJ, Auger JM, Van Der Meijden PE, Van Zandvoort MA, Oude Egbrink MG, Nieswandt B, Heemskerk JW. The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo. (2005) Arterioscler Thromb Vasc Biol 25:2673-8. 10.1161/01.ATV.0000193568.71980.4a. 16254207

Aktas B, Pozgajova M, Bergmeier W, Sunnarborg S, Offermanns S, Lee D, Wagner DD, Nieswandt B. Aspirin induces platelet receptor shedding via ADAM17 (TACE). (2005) J Biol Chem 280:39716-22. 10.1074/jbc.M507762200. 16179345

Kuhl C, Atzberger A, Iborra F, Nieswandt B, Porcher C, Vyas P. GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1. (2005) Mol Cell Biol 25:8592-606. 10.1128/MCB.25.19.8592-8606.2005. 16166640

Patel SR, Richardson JL, Schulze H, Kahle E, Galjart N, Drabek K, Shivdasani RA, Hartwig JH, Italiano JE, Jr.. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. (2005) Blood 106:4076-85. 10.1182/blood-2005-06-2204. 16118321

Nieswandt B, Aktas B, Moers A, Sachs UJ. Platelets in atherothrombosis: lessons from mouse models. (2005) J Thromb Haemost 3:1725-36. 10.1111/j.1538-7836.2005.01488.x. 16102039

Schulze H, Shivdasani RA. Mechanisms of thrombopoiesis. (2005) J Thromb Haemost 3:1717-24. 10.1111/j.1538-7836.2005.01426.x. 16102038

Leng XH, Zhang W, Nieswandt B, Bray PF. Effects of estrogen replacement therapies on mouse platelet function and glycoprotein VI levels. (2005) Circ Res 97:415-7. 10.1161/01.RES.0000181025.43762.cf. 16100041

Renne T, Pozgajova M, Gruner S, Schuh K, Pauer HU, Burfeind P, Gailani D, Nieswandt B. Defective thrombus formation in mice lacking coagulation factor XII. (2005) J Exp Med 202:271-81. 10.1084/jem.20050664. 16009717

Begonja AJ, Gambaryan S, Geiger J, Aktas B, Pozgajova M, Nieswandt B, Walter U. Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway. (2005) Blood 106:2757-60. 10.1182/blood-2005-03-1047. 15976180

Penz S, Reininger AJ, Brandl R, Goyal P, Rabie T, Bernlochner I, Rother E, Goetz C, Engelmann B, Smethurst PA, Ouwehand WH, Farndale R, Nieswandt B, Siess W. Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI. (2005) FASEB J 19:898-909. 10.1096/fj.04-2748com. 15923400

Elzey BD, Grant JF, Sinn HW, Nieswandt B, Waldschmidt TJ, Ratliff TL. Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation. (2005) J Leukoc Biol 78:80-4. 10.1189/jlb.1104669. 15899982

Germeshausen M, Schulze H, Kratz C, Wilkens L, Repp R, Shannon K, Welte K, Ballmaier M. An acquired G-CSF receptor mutation results in increased proliferation of CMML cells from a patient with severe congenital neutropenia. (2005) Leukemia 19:611-7. 10.1038/sj.leu.2403663. 15729385

Rabie T, Strehl A, Ludwig A, Nieswandt B. Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. (2005) J Biol Chem 280:14462-8. 10.1074/jbc.M500041200. 15691827

Gruner S, Prostredna M, Koch M, Miura Y, Schulte V, Jung SM, Moroi M, Nieswandt B. Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice. (2005) Blood 105:1492-9. 10.1182/blood-2004-06-2391. 15507524

2004

Nieswandt B, Offermanns S. Pharmacology of platelet adhesion and aggregation. (2004) Handb Exp Pharmacol 437-71. 10.1007/978-3-540-68170-0_14. 20455101

Gruner S, Prostredna M, Aktas B, Moers A, Schulte V, Krieg T, Offermanns S, Eckes B, Nieswandt B. Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy. (2004) Circulation 110:2946-51. 10.1161/01.CIR.0000146341.63677.3C. 15505105

Schulze H, Shivdasani RA. Molecular mechanisms of megakaryocyte differentiation. (2004) Semin Thromb Hemost 30:389-98. 10.1055/s-2004-833474. 15354260

Moers A, Wettschureck N, Gruner S, Nieswandt B, Offermanns S. Unresponsiveness of platelets lacking both Galpha(q) and Galpha(13). Implications for collagen-induced platelet activation. (2004) J Biol Chem 279:45354-9. 10.1074/jbc.M408962200. 15326177

Schulze H, Korpal M, Bergmeier W, Italiano JE, Jr., Wahl SM, Shivdasani RA. Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. (2004) Blood 104:3949-57. 10.1182/blood-2004-03-1179. 15315966

Nieswandt B, Schulte V, Bergmeier W. Flow-cytometric analysis of mouse platelet function. (2004) Methods Mol Biol 272:255-68. 10.1385/1-59259-782-3:255. 15226549

Kuijpers MJ, Schulte V, Oury C, Lindhout T, Broers J, Hoylaerts MF, Nieswandt B, Heemskerk JW. Facilitating roles of murine platelet glycoprotein Ib and alphaIIbbeta3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formation. (2004) J Physiol 558:403-15. 10.1113/jphysiol.2004.062414. 15155790

Bergmeier W, Rabie T, Strehl A, Piffath CL, Prostredna M, Wagner DD, Nieswandt B. GPVI down-regulation in murine platelets through metalloproteinase-dependent shedding. (2004) Thromb Haemost 91:951-8. 10.1160/TH03-12-0795. 15116256

Li TT, Larrucea S, Souza S, Leal SM, Lopez JA, Rubin EM, Nieswandt B, Bray PF. Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen. (2004) Blood 103:3396-402. 10.1182/blood-2003-10-3721. 14739220

Massberg S, Gruner S, Konrad I, Garcia Arguinzonis MI, Eigenthaler M, Hemler K, Kersting J, Schulz C, Muller I, Besta F, Nieswandt B, Heinzmann U, Walter U, Gawaz M. Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice. (2004) Blood 103:136-42. 10.1182/blood-2002-11-3417. 12933589

2003

Moers A, Nieswandt B, Massberg S, Wettschureck N, Gruner S, Konrad I, Schulte V, Aktas B, Gratacap MP, Simon MI, Gawaz M, Offermanns S. G13 is an essential mediator of platelet activation in hemostasis and thrombosis. (2003) Nat Med 9:1418-22. 10.1038/nm943. 14528298

Bergmeier W, Burger PC, Piffath CL, Hoffmeister KM, Hartwig JH, Nieswandt B, Wagner DD. Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. (2003) Blood 102:4229-35. 10.1182/blood-2003-04-1305. 12907434

Gruner S, Prostredna M, Schulte V, Krieg T, Eckes B, Brakebusch C, Nieswandt B. Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo. (2003) Blood 102:4021-7. 10.1182/blood-2003-05-1391. 12893753

Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz SR, Stein CS, Nieswandt B, Wang Y, Davidson BL, Ratliff TL. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. (2003) Immunity 19:9-19. 10.1016/s1074-7613(03)00177-8. 12871635

Voit S, Udelhoven M, Lill G, Aktas B, Nieswandt B, Schror K, Weber AA. The C-terminal peptide of thrombospondin-1 stimulates distinct signaling pathways but induces an activation-independent agglutination of platelets and other cells. (2003) FEBS Lett 544:240-5. 10.1016/s0014-5793(03)00472-1. 12782324

Mangin P, Nonne C, Eckly A, Ohlmann P, Freund M, Nieswandt B, Cazenave JP, Gachet C, Lanza F. A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1. (2003) FEBS Lett 542:53-9. 10.1016/s0014-5793(03)00337-5. 12729897

Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor?. (2003) Blood 102:449-61. 10.1182/blood-2002-12-3882. 12649139

Poujol C, Bergmeier W, Nurden P, Nieswandt B, Nurden A. Effect of infusing rat monoclonal antibodies to the murine GPIb-IX-V complex on platelet and megakaryocyte morphology in mice. (2003) Platelets 14:35-45. 12623445

Nieswandt B, Bergmeier W, Schulte V, Takai T, Baumann U, Schmidt RE, Zirngibl H, Bloch W, Gessner JE. Targeting of platelet integrin alphaIIbbeta3 determines systemic reaction and bleeding in murine thrombocytopenia regulated by activating and inhibitory FcgammaR. (2003) Int Immunol 15:341-9. 10.1093/intimm/dxg033. 12618478

Kuijpers MJ, Schulte V, Bergmeier W, Lindhout T, Brakebusch C, Offermanns S, Fassler R, Heemskerk JW, Nieswandt B. Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. (2003) FASEB J 17:685-7. 10.1096/fj.02-0381fje. 12586747

Schulte V, Rabie T, Prostredna M, Aktas B, Gruner S, Nieswandt B. Targeting of the collagen-binding site on glycoprotein VI is not essential for in vivo depletion of the receptor. (2003) Blood 101:3948-52. 10.1182/blood-2002-10-3242. 12531795

Massberg S, Gawaz M, Gruner S, Schulte V, Konrad I, Zohlnhofer D, Heinzmann U, Nieswandt B. A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. (2003) J Exp Med 197:41-9. 10.1084/jem.20020945. 12515812

2002

Massberg S, Brand K, Gruner S, Page S, Muller E, Muller I, Bergmeier W, Richter T, Lorenz M, Konrad I, Nieswandt B, Gawaz M. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. (2002) J Exp Med 196:887-96. 10.1084/jem.20012044. 12370251

Nieswandt B, Schulte V, Zywietz A, Gratacap MP, Offermanns S. Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets. (2002) J Biol Chem 277:39493-8. 10.1074/jbc.M207256200. 12183468

Kaluzhny Y, Yu G, Sun S, Toselli PA, Nieswandt B, Jackson CW, Ravid K. BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation. (2002) Blood 100:1670-8. 10.1182/blood-2001-12-0263. 12176887

Snell DC, Schulte V, Jarvis GE, Arase K, Sakurai D, Saito T, Watson SP, Nieswandt B. Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands. (2002) Biochem J 368:293-300. 10.1042/BJ20020335. 12117414

Bergmeier W, Schulte V, Brockhoff G, Bier U, Zirngibl H, Nieswandt B. Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody. (2002) Cytometry 48:80-6. 10.1002/cyto.10114. 12116368

Poujol C, Ware J, Nieswandt B, Nurden AT, Nurden P. Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model. (2002) Exp Hematol 30:352-60. 10.1016/s0301-472x(02)00774-9. 11937271

Holtkotter O, Nieswandt B, Smyth N, Muller W, Hafner M, Schulte V, Krieg T, Eckes B. Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. (2002) J Biol Chem 277:10789-94. 10.1074/jbc.M112307200. 11788609

2001

Germeshausen M, Schulze H, Ballmaier M, Zeidler C, Welte K. Mutations in the gene encoding neutrophil elastase (ELA2) are not sufficient to cause the phenotype of congenital neutropenia. (2001) Br J Haematol 115:222-4. 10.1046/j.1365-2141.2001.03069.x. 11722436

Kauffenstein G, Bergmeier W, Eckly A, Ohlmann P, Leon C, Cazenave JP, Nieswandt B, Gachet C. The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism. (2001) FEBS Lett 505:281-90. 10.1016/s0014-5793(01)02824-1. 11566191

Gratacap MP, Payrastre B, Nieswandt B, Offermanns S. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. (2001) J Biol Chem 276:47906-13. 10.1074/jbc.M104442200. 11560922

Germeshausen M, Schulze H, Gaudig A, Krukemeier S, Strauss G, Welte K, Ballmaier M. [Congenital amegakaryocytic thrombocytopenia (CAMT) - a defect of the thrombopoietin receptor c-Mpl]. (2001) Klin Padiatr 213:155-61. 10.1055/s-2001-16846. 11528548

Moog S, Mangin P, Lenain N, Strassel C, Ravanat C, Schuhler S, Freund M, Santer M, Kahn M, Nieswandt B, Gachet C, Cazenave JP, Lanza F. Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation. (2001) Blood 98:1038-46. 10.1182/blood.v98.4.1038. 11493449

Nieswandt B, Bergmeier W, Eckly A, Schulte V, Ohlmann P, Cazenave JP, Zirngibl H, Offermanns S, Gachet C. Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation. (2001) Blood 97:3829-35. 10.1182/blood.v97.12.3829. 11389023

Bergmeier W, Bouvard D, Eble JA, Mokhtari-Nejad R, Schulte V, Zirngibl H, Brakebusch C, Fassler R, Nieswandt B. Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibalpha. (2001) J Biol Chem 276:25121-6. 10.1074/jbc.M103892200. 11352922

Andrews RK, Gardiner EE, Asazuma N, Berlanga O, Tulasne D, Nieswandt B, Smith AI, Berndt MC, Watson SP. A novel viper venom metalloproteinase, alborhagin, is an agonist at the platelet collagen receptor GPVI. (2001) J Biol Chem 276:28092-7. 10.1074/jbc.M011352200. 11344165

Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R. Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. (2001) EMBO J 20:2120-30. 10.1093/emboj/20.9.2120. 11331578

Chouchakova N, Skokowa J, Baumann U, Tschernig T, Philippens KM, Nieswandt B, Schmidt RE, Gessner JE. Fc gamma RIII-mediated production of TNF-alpha induces immune complex alveolitis independently of CXC chemokine generation. (2001) J Immunol 166:5193-200. 10.4049/jimmunol.166.8.5193. 11290803

Germeshausen M, Ballmaier M, Schulze H, Welte K, Flohr T, Beiske K, Storm-Mathisen I, Abrahamsen TG. Granulocyte colony-stimulating factor receptor mutations in a patient with acute lymphoblastic leukemia secondary to severe congenital neutropenia. (2001) Blood 97:829-30. 10.1182/blood.v97.3.829. 11227095

Nieswandt B, Schulte V, Bergmeier W, Mokhtari-Nejad R, Rackebrandt K, Cazenave JP, Ohlmann P, Gachet C, Zirngibl H. Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. (2001) J Exp Med 193:459-69. 10.1084/jem.193.4.459. 11181698

Schulte V, Snell D, Bergmeier W, Zirngibl H, Watson SP, Nieswandt B. Evidence for two distinct epitopes within collagen for activation of murine platelets. (2001) J Biol Chem 276:364-8. 10.1074/jbc.M007536200. 11036078

2000

Nieswandt B, Bergmeier W, Rackebrandt K, Gessner JE, Zirngibl H. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. (2000) Blood 96:2520-7. 11001906

Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner JE, Zirngibl H. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. (2000) J Biol Chem 275:23998-4002. 10.1074/jbc.M003803200. 10825177

Schulze H, Ballmaier M, Welte K, Germeshausen M. Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets. (2000) Exp Hematol 28:294-304. 10.1016/s0301-472x(99)00154-x. 10720694

Bergmeier W, Rackebrandt K, Schroder W, Zirngibl H, Nieswandt B. Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies. (2000) Blood 95:886-93. 10648400

1999

Cremer M, Schulze H, Linthorst G, Folman CC, Wehnert S, Strauss G, Von Dem Borne AE, Welte K, Ballmaier M. Serum levels of thrombopoietin, IL-11, and IL-6 in pediatric thrombocytopenias. (1999) Ann Hematol 78:401-7. 10.1007/s002770050538. 10525827

Eilers M, Schulze H, Welte K, Ballmaier M. Thrombopoietin acts synergistically on Ca(2+) mobilization in platelets caused by ADP or thrombin receptor agonist peptide. (1999) Biochem Biophys Res Commun 263:230-8. 10.1006/bbrc.1999.1352. 10486282

Nieswandt B, Echtenacher B, Wachs FP, Schroder J, Gessner JE, Schmidt RE, Grau GE, Mannel DN. Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice. (1999) Blood 94:684-93. 10397735

Nieswandt B, Hafner M, Echtenacher B, Mannel DN. Lysis of tumor cells by natural killer cells in mice is impeded by platelets. (1999) Cancer Res 59:1295-300. 10096562

1998

Ballmaier M, Schulze H, Cremer M, Folman CC, Strauss G, Welte K. Defective c-Mpl signaling in the syndrome of thrombocytopenia with absent radii. (1998) Stem Cells 16 Suppl 2:177-84. 10.1002/stem.5530160720. 11012189

1997

Ballmaier M, Schulze H, Strauss G, Cherkaoui K, Wittner N, Lynen S, Wolters S, Bogenberger J, Welte K. Thrombopoietin in patients with congenital thrombocytopenia and absent radii: elevated serum levels, normal receptor expression, but defective reactivity to thrombopoietin. (1997) Blood 90:612-9. 9226161

1996

Strauss G, Ballmaier M, Schulze H, Bogenberger J, Riehm H, Welte K. [Significance of thrombopoietin and its receptor c-Mpl in regulation of thrombocytopoiesis in thrombocytopenia]. (1996) Klin Padiatr 208:168-71. 10.1055/s-2008-1046468. 8926683

1995

Stoelcker B, Hafner M, Orosz P, Nieswandt B, Mannel DN. Role of adhesion molecules and platelets in TNF-induced adhesion of tumor cells to endothelial cells: implications for experimental metastasis. (1995) J Inflamm 46:155-67. 8844496