Publications

2020

Becker IC, Scheller I, Wackerbarth LM, et al. Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1. Blood Adv. 2020;4(10):2124-2134.
doi:10.1182/bloodadvances.2019001303

Chatterjee M. Platelet lipidome: Dismantling the “Trojan horse” in the bloodstream. J Thromb Haemost. 2020;18(3):543-557.
doi:10.1111/jth.14721

Colberg L, Cammann C, Greinacher A, Seifert U. Structure and function of the ubiquitin-proteasome system in platelets. J Thromb Haemost. 2020;18(4):771-780.
doi:10.1111/jth.14730

Eekels JJM, Pachler C, Krause N, Muhr T, Waltl G, Greinacher A. Ticagrelor causes false-negative functional tests for heparin-induced thrombocytopenia. Blood. 2020;135(11):875-878.
doi:10.1182/blood.2019003582

Gorelashvili MG, Angay O, Hemmen K, Klaus V, Stegner D, Heinze KG. Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics. Haematologica. 2020;105(4):895-904.
doi:10.3324/haematol.2018.202010

J. Rheinlaender and T.E. Schäffer. The effect of finite sample thickness in scanning ion conductance microscopy stiffness measurements.
Applied Physics Letters 117, 113701 (2020).

Köhler D, Granja T, Volz J, et al. Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. Nat Commun. 2020;11(1):1315. Published 2020 Mar 11.
doi:10.1038/s41467-020-14958-x

Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, et al. Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3. Blood. 2020;135(14):1146-1160.
doi:10.1182/blood.2019002649

Nguyen TH, Xu Y, Brandt S, et al. Characterization of the interaction between platelet factor 4 and homogeneous synthetic low molecular weight heparins. J Thromb Haemost. 2020;18(2):390-398.
doi:10.1111/jth.14657

Rath D, von Ungern-Sternberg S, Heinzmann D, et al. Platelet surface expression of cyclophilin A is associated with increased mortality in patients with symptomatic coronary artery disease. J Thromb Haemost. 2020;18(1):234-242.
doi:10.1111/jth.14635

Scheller I, Stritt S, Beck S, et al. Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets. Haematologica. 2020;105(6):1667-1676.
doi:10.3324/haematol.2019.225516

Schneider F, Horowitz A, Lesch KP, Dandekar T. Delaying memory decline: different options and emerging solutions. Transl Psychiatry. 2020;10(1):13. Published 2020 Jan 21.
doi:10.1038/s41398-020-0697-x

Shityakov S, Fischer A, Su KP, Hussein AA, Dandekar T, Broscheit J. Novel approach for characterizing propofol binding affinities to 2 serum albumins from different species. ACS Omega Article ASAP.
doi: 10.1021/acsomega.0c01295

Volz J, Kusch C, Beck S, Popp M, Vögtle T, Meub M, Scheller I, Heil HS, Preu J, Schuhmann MK, Hemmen K, Premsler T, Sickmann A, Heinze KG, Stegner D, Stoll G, Braun A, Sauer M, Nieswandt B. BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation. J Clin Invest. 2020 Aug 4:136457.
doi: 10.1172/JCI136457. Epub ahead of print. PMID: 32750041.

2019

Breitenbach T, Liang C, Beyersdorf N, Dandekar T. Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks. PLoS Comput Biol. 2019;15(7):e1007075. Published 2019 Jul 16.
doi:10.1371/journal.pcbi.1007075

Breitenbach T, Lorenz K, Dandekar T. How to Steer and Control ERK and the ERK Signaling Cascade Exemplified by Looking at Cardiac Insufficiency. Int J Mol Sci. 2019;20(9):2179. Published 2019 May 2.
doi:10.3390/ijms20092179

Cebo M, Schlotterbeck J, Gawaz M, Chatterjee M, Lämmerhofer M. Simultaneous targeted and untargeted UHPLC-ESI-MS/MS method with data-independent acquisition for quantification and profiling of (oxidized) fatty acids released upon platelet activation by thrombin. Anal Chim Acta. 2020;1094:57-69.
doi:10.1016/j.aca.2019.10.005

Dubrovin EV, Barinov NA, Schäffer TE, Klinov DV. In Situ Single-Molecule AFM Investigation of Surface-Induced Fibrinogen Unfolding on Graphite. Langmuir. 2019;35(30):9732-9739.
doi:10.1021/acs.langmuir.9b01178

Eekels JJM, Althaus K, Bakchoul T, et al. An international external quality assessment for laboratory diagnosis of heparin-induced thrombocytopenia. J Thromb Haemost. 2019;17(3):525-531.
doi:10.1111/jth.14383

Geue S, Aurbach K, Manke MC, et al. Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis. Blood. 2019;134(21):1847-1858.
doi:10.1182/blood.2019000185

Gorelashvili MG, Angay O, Hemmen K, Klaus V, Stegner D, Heinze KG. Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics. Haematologica. 2019 Jun 27. pii: haematol.2018.202010. 
doi: 10.3324/haematol.2018.202010. [Epub ahead of print] PubMed PMID: 31248970.

Greinacher A, Eekels JJM. Diagnosis of hereditary platelet disorders in the era of next-generation sequencing: “primum non nocere”. J Thromb Haemost. 2019;17(3):551-554.
doi:10.1111/jth.14377

Greinacher A, Eekels JJM. Simplifying the diagnosis of inherited platelet disorders? The new tools do not make it any easier. Blood. 2019;133(23):2478-2483.
doi:10.1182/blood-2019-01-852350

Handtke S, Steil L, Palankar R, et al. Role of Platelet Size Revisited-Function and Protein Composition of Large and Small Platelets. Thromb Haemost. 2019;119(3):407-420.
doi:10.1055/s-0039-1677875

Heinzmann D, Klingel K, Müller K, Kumbrink J, Kirchner T, Schreieck J, Gawaz M, Seizer P. Mitochondrial Dynamics in Tachycardiomyopathy. Cell Physiol Biochem. 2019;52(3):435-438.
doi: 10.33594/000000031. Epub 2019 Mar 15. PubMed PMID: 30873819.

Körner A, Schlegel M, Kaussen T, et al. Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A. Nat Commun. 2019;10(1):633. Published 2019 Feb 7.
doi:10.1038/s41467-019-08328-5

Kollikowski AM, Amaya F, Stoll G, Müllges W, Schuhmann MK, Pham M. Impact of landmark endovascular stroke trials on logistical performance measures: a before-and-after evaluation of real-world data from a regional stroke system of care. J Neurointerv Surg. 2019;11(6):563-568.
doi:10.1136/neurintsurg-2018-014286

Kiran Gotru S, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM, Braun A. Defective Zn(2+) homeostasis in mouse and human platelets with α- and δ-storage pool diseases. Sci Rep. 2019 Jun 6;9(1):8333.
doi: 10.1038/s41598-019-44751-w. PubMed PMID: 31171812

Krauel K, Preuße P, Warkentin TE, et al. Fibronectin modulates formation of PF4/heparin complexes and is a potential factor for reducing risk of developing HIT. Blood. 2019;133(9):978-989.
doi:10.1182/blood-2018-05-850370

Nguyen TH, Wesche J, Raschke R, Strobel U, Bui VC, Delcea M, Greinacher A. Reactivity of platelet-activating and nonplatelet-activating anti-PF4/heparin antibodies in enzyme immunosorbent assays under different conditions. J Thromb Haemost. 2019 Jul;17(7):1113-1119.
doi: 10.1111/jth.14455. Epub 2019 May 17. PubMed PMID: 31009154.

Sauter RJ, Sauter M, Obrich M, et al. Anaphylatoxin Receptor C3aR Contributes to Platelet Function, Thrombus Formation and In Vivo Haemostasis. Thromb Haemost. 2019;119(1):179-182.
doi:10.1055/s-0038-1676349

Schuhmann MK, Kraft P, Bieber M, Kollikowski AM, Schulze H, Nieswandt B, Pham M, Stegner D, Stoll G. Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice. Int J Mol Sci. 2019 Apr 24;20(8). pii: E2019.
doi: 10.3390/ijms20082019. PubMed PMID: 31022936; PubMed Central

Schuhmann MK, Stoll G, Bohr A, Volkmann J, Fluri F. Electrical Stimulation of the Mesencephalic Locomotor Region Attenuates Neuronal Loss and Cytokine Expression in the Perifocal Region of Photothrombotic Stroke in Rats. Int J Mol Sci. 2019 May 11;20(9). pii: E2341. 
doi: 10.3390/ijms20092341. PubMed PMID: 31083528

Schuhmann MK, Stoll G, Papp L, Bohr A, Volkmann J, Fluri F. Electrical Stimulation of the Mesencephalic Locomotor Region Has No Impact on Blood-Brain Barrier Alterations after Cerebral Photothrombosis in Rats. Int J Mol Sci. 2019 Aug 19;20(16). pii: E4036.
doi: 10.3390/ijms20164036. PubMed PMID: 31430854

Schurr Y, Sperr A, Volz J, et al. Platelet lamellipodium formation is not required for thrombus formation and stability. Blood. 2019;134(25):2318-2329.
doi:10.1182/blood.2019002105 

Schurr Y, Spindler M, Kurz H, Bender M. The cytoskeletal crosslinking protein MACF1 is dispensable for thrombus formation and hemostasis. Sci Rep. 2019;9(1):7726. Published 2019 May 22.
doi:10.1038/s41598-019-44183-6

Semeniak D, Faber K, Öftering P, Manukjan G, Schulze H. Impact of Itga2-Gp6-double collagen receptor deficient mice for bone marrow megakaryocytes and platelets. PLoS One. 2019;14(8):e0216839. Published 2019 Aug 9.
doi:10.1371/journal.pone.0216839

Shvedova M, Litvak MM, Roberts JD Jr, Fukumura D, Suzuki T, Şencan İ, Li G, Reventun P, Buys ES, Kim HH, Sakadžić S, Ayata C, Huang PL, Feil R, Atochin DN. cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice. J Cereb Blood Flow Metab. 2019 Aug 18:271678X19870583.
doi: 10.1177/0271678X19870583. [Epub ahead of print] PubMed PMID: 31423931.

Simeonov S , Schäffer TE . High-speed scanning ion conductance microscopy for sub-second topography imaging of live cells. Nanoscale. 2019;11(17):8579-8587.
doi:10.1039/c8nr10162k

Stegner D, Hofmann S, Schuhmann MK, Kraft P, Herrmann AM, Popp S, Höhn M, Popp M, Klaus V, Post A, Kleinschnitz C, Braun A, Meuth SG, Lesch KP, Stoll G, Kraft R, Nieswandt B. Loss of Orai2-Mediated Capacitative Ca(2+) Entry Is Neuroprotective in Acute Ischemic Stroke. Stroke. 2019 Nov;50(11):3238-3245.
doi: 10.1161/STROKEAHA.119.025357. Epub 2019 Sep 25. PubMed PMID: 31551038.

Stoll G, Nieswandt B. Thrombo-inflammation in acute ischaemic stroke – implications for treatment. Nat Rev Neurol. 2019 Jul 1.
doi: 10.1038/s41582-019-0221-1. [Epub ahead of print] Review. PubMed PMID: 31263257.

Volz J, Mammadova-Bach E, Gil-Pulido J, et al. Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice. Blood. 2019;133(25):2696-2706.
doi:10.1182/blood.2018877043

2018

Droppa M, Borst O, Katzenberger T, Krause R, Bramlage K, Bramlage P, Lausberg HF, Schlensak C, Grasshoff C, Gawaz M, Geisler T. Clinical and economical impact of the presence of an extended heart team throughout the balloon-expandable transcatheter aortic valve implantation procedure. Clin Res Cardiol. 2018 Aug 24.doi: 10.1007/s00392-018-1359-3. [Epub ahead of print] PubMed PMID: 30167808

Peng B, Geue S, Coman C, Münzer P, Kopczynski D, Has C, Hoffmann N, Manke MC, Lang F, Sickmann A, Gawaz M, Borst O, Ahrends R. Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome. Blood. 2018 Aug 2;132(5):e1-e12. doi: 10.1182/blood-2017-12-822890. Epub 2018 May 21. PubMed PMID: 29784642; PubMed Central PMCID: PMC6137561.

Sauter RJ, Sauter M, Reis ES, Emschermann FN, Nording H, Ebenhöch S, Kraft P, Münzer P, Mauler M, Rheinlaender J, Madlung J, Edlich F, Schäffer TE, Meuth SG, Düerschmied D, Geisler T, Borst O, Gawaz M, Kleinschnitz C, Lambris JD, Langer HF. A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis. Circulation. 2018 May 25. pii:CIRCULATIONAHA.118.034600. doi: 10.1161/CIRCULATIONAHA.118.034600. [Epub ahead of print] PubMed PMID: 29802205

Spindler M, van Eeuwijk JMM, Schurr Y, Nurden P, Nieswandt B, Stegner D, Reinhold A, Bender M. ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia. Blood. 2018 Aug 9;132(6):635-646. doi: 10.1182/blood-2018-01-829259. Epub 2018 Jun 27. PubMed PMID: 29950291