Publications

2022

Becker IC, Nagy Z, Manukjan G, Haffner-Luntzer M, Englert M, Heib T, Vögtle T, Gross C, Bharti R, Dietrich S, Mott K, Heck J, Stegmaier S, Baranowsky A, Schinke T, Schlegel N, Heckel T, Stegner D, Pleines I, Ignatius A, Schulze H, Nieswandt B. G6b-B regulates an essential step in megakaryocyte maturation. Blood Adv. 2022 Feb 8: bloodadvances.2021006151.
doi: 10.1182/bloodadvances.2021006151. Online ahead of print. PMID: 35134123.

Heil HS, Aigner M, Maier S, Gupta P, Evers LMC, Göb V, Kusch C, Meub M, Nieswandt B, Stegner D, Heinze KG. Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy. Platelets. 2022 Feb 2:1-10.
doi: 10.1080/09537104.2021.2023735. Online ahead of print. PMID: 35109754.

Jahn K, Handtke S, Palankar R, Kohler TP, Wesche J, Wolff M, Bayer J, Wolz C, Greinacher A, Hammerschmidt S. α-hemolysin of Staphylococcus aureus impairs thrombus formationJ Thromb Haemost. 2022 Mar 18. doi: 10.1111/jth.15703. Epub ahead of print. PMID: 35303391. https://pubmed.ncbi.nlm.nih.gov/35303391/

Jahn K, Kohler TP, Swiatek LS, Wiebe S, Hammerschmidt S. Platelets, Bacterial Adhesins and the Pneumococcus. Cells. 2022 Mar 25;11(7):1121. doi: 10.3390/cells11071121. PMID: 35406684; PMCID: PMC8997422.

Li P, Gawaz M, Chatterjee M, Lämmerhofer M. Isomer-selective analysis of inositol phosphates with differential isotope labelling by phosphate methylation using liquid chromatography with tandem mass spectrometry. Anal Chim Acta. 2022;1191:339286. doi: 10.1016/j.aca.2021.339286. PMID: 35033253

Rosa A, Butt E, Hopper CP, Loroch S, Bender M, Schulze H, Sickmann A, Vorlova S, Seizer P, Heinzmann D, Zernecke A. Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets. Int J Mol Sci. 2022 Jan 27;23(3):1469. doi: 10.3390/ijms23031469. PMID: 35163387; PMCID: PMC8836233.

Stegner D, Göb V, Krenzlin V, Beck S, Hemmen K, Schuhmann MK, Schörg B, Hackenbroch C, May F, Burkard P, Pinnecker J, Zernecke A, Rosenberger P, Greinacher A, Pichler BJ, Heinze KG, Stoll G, Nieswandt B. Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation. Nat Cardiovasc Res 1, 132–141 (2022). https://doi.org/10.1038/s44161-021-00017-1

Sachs L, Wesche J, Lenkeit L, Greinacher A, Bender M, Otto O, Palankar R. Ex vivo anticoagulants affect human blood platelet biomechanics with implications for high-throughput functional mechanophenotyping. Commun Biol. 2022 Jan 21;5(1):86.
doi: 10.1038/s42003-021-02982-6. PMID: 35064207.

2021

Althaus K, Marini I, Zlamal J, Pelzl L, Singh A, Häberle H, Mehrländer M, Hammer S, Schulze H, Bitzer M, Malek N, Rath D, Bösmüller H, Nieswandt B, Gawaz M, Bakchoul T, Rosenberger P. Antibody-induced procoagulant platelets in severe COVID-19 infection. Blood. 2021;137(8):1061-1071. DOI: 10.1182/blood.2020008762 Beck S, Stegner D, Loroch S, Baig AA, Göb V, Schumbrutzki C, Eilers E, Sickmann A, May F, Nolte MW, Panousis C, Nieswandt B. Generation of a humanized FXII knock-in mouse-A powerful model system to test novel anti-thrombotic agents. J Thromb Haemost. 2021 Nov;19(11):2835-2840. doi: 10.1111/jth.15488. Epub 2021 Aug 19. PMID: 34363738. Bender M, Palankar R. Platelet Shape Changes during Thrombus Formation: Role of Actin-Based Protrusions. Hamostaseologie. 2021 Feb;41:14-21. doi: 10.1055/a-1325-0993. Epub 2021 Feb 15. Bieber M, Schuhmann MK, Kollikowski AM, Stegner D, Nieswandt B, Pham M, Stoll G. Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice. Exp Neurol. 2021 Oct; 344:113804. doi: 10.1016/j.expneurol.2021.113804. Epub 2021 Jul 6. PMID: 34237320. Cebo M, Dittrich K, Fu X, Manke MC, Emschermann F, Rheinlaender J, von Eysmondt H, Ferreirós N, Sudmann-Innerhofer J, Witte A, Pelzl L, Borst O, Geisler T, Rath D, Bakchoul T, Gawaz M, Schäffer TEE, Lämmerhofer M, Chatterjee M. Platelet ACKR3/CXCR7 Favors Anti-Platelet Lipids over an Atherothrombotic Lipidome and Regulates Thrombo-inflammation. Blood. 2021 Dec 14:blood.2021013097. doi: 10.1182/blood.2021013097. PMID: 34905596  Cebo M, Calderón Castro C, Schlotterbeck J, Gawaz M, Chatterjee M, Lämmerhofer M. Untargeted UHPLC-ESI-QTOF-MS/MS analysis with targeted feature extraction at precursor and fragment level for profiling of the platelet lipidome with ex vivo thrombin-activation. J Pharm Biomed Anal. 2021;205:114301. doi: 10.1016/j.jpba.2021.114301. PMID: 34391135 Chatterjee M. Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology. Cells. 2022. doi: 10.3390/cells11020213. PMID: 35053329 Essig F, Kollikowski AM, Müllges W, Stoll G, Haeusler KG, Schuhmann MK, Pham M. Local Cerebral Recombinant Tissue Plasminogen Activator Concentrations During Acute Stroke. JAMA Neurol. 2021 May 1;78(5):615-617. doi: 10.1001/jamaneurol.2021.0065. PMID: 33683294; PMCID: PMC7941250. Feil R, Lehners M, Stehle D, Feil S. Visualising and understanding cGMP signals in the cardiovascular system. Br J Pharmacol. 2021 Apr 20. doi: 10.1111/bph.15500 Franke M, Bieber M, Kraft P, Weber ANR, Stoll G, Schuhmann MK. The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice. Brain Behav Immun. 2021 Feb;92:223-233. doi: 10.1016/j.bbi.2020.12.009. Epub 2020 Dec 9. PMID: 33307174. Franke M, Bieber M, Stoll G, Schuhmann MK. Validity and Efficacy of Methods to Define Blood Brain Barrier Integrity in Experimental Ischemic Strokes: A Comparison of Albumin Western Blot, IgG Western Blot and Albumin Immunofluorescence. Methods Protoc. 2021 Mar 23;4(1):23. doi: 10.3390/mps4010023. PMID: 33806760; PMCID: PMC8005953. Göb V, Voll MG, Zimmermann L, Hemmen K, Stoll G, Nieswandt B, Schuhmann MK, Heinze KG, Stegner D. Infarct growth precedes cerebral thrombosis following experimental stroke in mice. Sci Rep. 2021 Nov 24;11(1):22887. doi: 10.1038/s41598-021-02360-6. PMID: 34819574. Hammer S, Häberle H, Schlensak C, Bitzer M, Malek NP, Handgretinger R, Lang P, Hörber S, Peter A, Martus P, Mirakaj V, Gawaz M, Geisler T, Althaus K, Rosenberger P, Bakchoul T. Severe SARS-CoV-2 Infection Inhibits Fibrinolysis Leading to Changes in Viscoelastic Properties of Blood Clot: A Descriptive Study of Fibrinolysis in COVID-19. Thromb Haemost. 2021 Feb 25. Online ahead of print. doi: 10.1055/a-1400-6034. PMID: 33634444 Harm T, Bild A, Dittrich K, Goldschmied A, Nestele J, Chatterjee M, Fu X, Kolb, K, Castor T, Borst O, Geisler T, Rath D, Lämmerhofer M, Gawaz M. Acute coronary syndrome is associated with a substantial change in the platelet lipidome. Cardiovasc Res. 2021. doi: 10.1093/cvr/cvab238. PMID: 34323932 Heib T, Herrmans J, Manukjan G, Englert M, Kusch C, Becker IC, Gerber A, Wackerbarth LM, Burkhard P, Dandekar T, Balkenhol J, Jahn D, Beck S, Meub M, Dütting S, Stigloher C, Sauer M, Cherpokova D, Schulze H, Brakebusch C, Nieswandt B, Nagy Z, and Pleines I. RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes. Cell Reports, 2021; 35(6):109102. doi: 10.1016/j.celrep.2021.109102. PMID: 33979620 Henes JK, Groga-Bada P, Schaeffeler E, Winter S, Hack L, Zdanyte M, Mueller K, Droppa M, Stimpfle F, Gawaz M, Langer H, Schwab M, Geisler T, Rath D. C5 Variant rs10985126 is Associated with Mortality in Patients with Symptomatic Coronary Artery Disease. Pharmgenomics Pers Med. 2021 Jul 21;14:893-903. doi: 10.2147/PGPM.S307827. eCollection 2021. PMID: 34321906 Hinterleitner C, Zhou Y, Tandler C, Heitmann JS, Kropp KN, Hinterleitner M, Koch A, Hartkopf AD, Zender L, Salih HR, Maurer S. 2021. Platelet-Expressed TNFRSF13B (TACI) Predicts Breast Cancer Progression. Front Oncol. 2021 Mar 17;11:642170. doi: 10.3389/fonc.2021.642170 Hinterleitner M, Sipos B, Wagner V, Grottenthaler JM, Lauer UM, Zender L, Hinterleitner C. 2021 Platelet-Expressed Synaptophysin (pSyn) as Novel Biomarker in Neuroendocrine Malignancies. Cancers (Basel). 2021 May 11;13(10):2286. doi: 10.3390/cancers13102286. Kollikowski AM, Pham M, März AG, Papp L, Nieswandt B, Stoll G, Schuhmann MK. Platelet Activation and Chemokine Release Are Related to Local Neutrophil-Dominant Inflammation During Hyperacute Human Stroke. Transl Stroke Res. 2021 Aug 28. doi: 10.1007/s12975-021-00938-w. Online ahead of print. PMID: 34455571. Kollikowski AM, Cattus F, Haag J, Feick J, März AG, Weidner F, Schuhmann MK, Müllges W, Stoll G, Pham M, Strinitz M. Progression of cerebral infarction before and after thrombectomy is modified by prehospital pathways. J Neurointerv Surg. 2021 May 13:neurintsurg-2020-017155. doi: 10.1136/neurintsurg-2020-017155. Epub ahead of print. PMID: 33986107. Langnau C, Rohlfing AK, Gekeler S, Günter M, Pöschel S, Petersen-Uribe Á, Jaeger P, Avdiu A, Harm T, Kreisselmeier KP, Castor T, Bakchoul T, Rath D, Gawaz MP, Autenrieth SE, Mueller KAL. Platelet Activation and Plasma Levels of Furin Are Associated With Prognosis of Patients With Coronary Artery Disease and COVID-19. Arterioscler Thromb Vasc Biol. 2021;41(6):2080-2096. DOI: 10.1161/ATVBAHA.120.315698 Li P, Gawaz M, Chatterjee M, Lämmerhofer M. 2021 Targeted Profiling of Short-, Medium-, and Long-Chain Fatty Acyl-Coenzyme As in Biological Samples by Phosphate Methylation Coupled to Liquid Chromatography-Tandem Mass Spectrometry. 2021. Anal Chem. 93:4342-4350. Li P, Lämmerhofer M. Isomer Selective Comprehensive Lipidomics Analysis of Phosphoinositides in Biological Samples by Liquid Chromatography with Data Independent Acquisition Tandem Mass Spectrometry. Anal Chem. 2021;93(27):9583-92. doi: 10.1021/acs.analchem.1c01751. PMID: 34191474 Manke MC, Geue S, Coman C, Peng B, Kollotzek F, Münzer P, Walker B, Huber SM, Rath D, Sickmann A, Stegner D, Duerschmied D, Lang F, Nieswandt B, Gawaz M, Ahrends R, Borst O. ANXA7 Regulates Platelet Lipid Metabolism and Ca2+ Release in Arterial Thrombosis. Circ Res. 2021 Aug 6;129(4):494-507. doi: 10.1161/CIRCRESAHA.121.319207. Epub 2021 Jun 28. PMID: 34176316. Mueller KAL, Jorbenadze R, Gawaz M, Schreieck J, Seizer P. “Mind the Gap”: An 85-Year-Old Man with Severe Tricuspid Valve Regurgitation Who Underwent Percutaneous Edge-to-Edge Valve Leaflet Plication Using the New and Advanced MitraClip XTR System. Am J Case Rep. 2021;22:e928089. doi: 10.12659/AJCR.928089. PMID: 33456048 Mueller KAL, Langnau C, Günter M, Pöschel S, Gekeler S, Petersen-Uribe Á, Kreisselmeier KP, Klingel K, Bösmüller H, Li B, Jaeger P, Castor T, Rath D, Gawaz MP, Autenrieth SE. Numbers and phenotype of non-classical CD14dimCD16+ monocytes are predictors of adverse clinical outcome in patients with coronary artery disease and severe SARS-CoV-2 infection. Cardiovasc Res. 2021;117(1):224-239. DOI: 10.1093/cvr/cvaa328 Müller II, Schneider M, Müller KAL, Lunov O, Borst O, Simmet T, Gawaz M. Protective role of Gremlin-1 in myocardial function. Eur J Clin Invest. 2021;51(7):e13539. DOI: 10.1111/eci.13539 Nording H, Baron L, Haberthür D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, Meusel M, Meyer-Saraei R, Hlushchuk R, Sedding D, Borst O, Eitel I, Karsten CM, Feil R, Pichler B, Erdmann J, Verschoor A, Chavakis E, Chavakis T, von Hundelshausen P, Köhl J, Gawaz M, Langer HF. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun. 2021 Jun 7;12(1):3352. doi: 10.1038/s41467-021-23499-w Petersen-Uribe A, Avdiu A, Martus P, Witzel K, Jaeger P, Zdanyte M, Heinzmann D, Tavlaki E, Warm V, Geisler T, Müller K, Gawaz M, Rath D. Impaired Myocardial Function Is Prognostic for Severe Respiratory Failure in the Course of COVID-19 Infection. Front Cardiovasc Med. 2021;8:584108. DOI: 10.3389/fcvm.2021.584108 Scheller I, Beck S, Göb V, Gross C, Neagoe RAI, Aurbach K, Bender M, Stegner D, Nagy Z, Nieswandt B. Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets. Haematologica. 2021 Aug 5. doi: 10.3324/haematol.2021.278537. Online ahead of print. PMID: 34348450. Schuhmann MK, Bieber M, Franke M, Kollikowski AM, Stegner D, Heinze KG, Nieswandt B, Pham M, Stoll G. Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice. J Neuroinflammation. 2021 Feb 18;18(1):46. doi: 10.1186/s12974-021-02095-1. PMID: 33602266; PMCID: PMC7890632. Seifert J, von Eysmondt H, Chatterjee M, Gawaz M, Schäffer TE. Effect of Oxidized LDL on Platelet Shape, Spreading, and Migration Investigated with Deep Learning Platelet Morphometry. Cells. 2021;10(11):2932. doi: 10.3390/cells10112932. PMID: 34831155 Seyhan M, Ungethüm K, Schuhmann MK, Mackenrodt D, Rücker V, Montellano FA, Wiedmann S, Rath D, Geisler T, Nieswandt B, Kraft P, Kleinschnitz C, Heuschmann PU.Feasibility of platelet marker analysis in ischemic stroke patients and their association with one-year outcome. A pilot project within a subsample of the Stroke Induced Cardiac Failure in Mice and Men (SICFAIL) cohort study. Platelets. 2021 Dec 7:1-9. doi: 10.1080/09537104.2021.2002834. Online ahead of print. PMID: 34875957. Stehle D, Xu MZ, Schomber T, Hahn MG, Schweda F, Feil S, Kraehling JR, Eitner F, Patzak A, Sandner P, Feil R, Benardeau A. Novel sGC activators increase glomerular cGMP, induce vasodilation, and improve blood flow in the murine kidney. Br J Pharmacol. 2021 Jun 7.doi: 10.1111/bph.15586 Tchernychev B, Li H, Lee SK, Gao X, Ramanarasimhaiah R, Liu G, Hall KC, Bernier SG, Jones JE, Feil S, Feil R, Buys ES, Graul RM, Frenette PS, Masferrer JL. Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso-occlusion and nephropathy in mouse models of sickle cell disease. Br J Pharmacol. 2021 Apr 17.doi: 10.1111/bph.15492 Wagner N*, Mott K*, Upcin B, Stegner D, Schulze H*, Ergün S. CXCL12-abundant reticular (CAR) cells direct megakaryocyte protrusions across the bone marrow sinusoid wall. Cells 2021; 10, 722. PMID: 33804965 Weiss L, Manukjan G, Pflug A, Winter N, Weigel M, Nagler N, Kredel M, Lam T-T, Nieswandt B, Weismann D, Schulze H. Acquired platelet GPVI receptor dysfunction in critically-ill patients with sepsis. Blood 2021; 137(22):3105-15. PMID: 33827131 Witte A, Rohlfing AK, Dannenmann B, Dicenta V, Nasri M, Kolb K, Sudmann J, Castor T, Rath D, Borst O, Skokowa J, Gawaz M. The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4. Cardiovasc Res. 2021;117(3):903-917. DOI: 10.1093/cvr/cvaa080 Zhou L, Heitmann JS, Clar KL, Kropp KN, Hinterleitner M, Koch A, Hartkopf A, Zender L, Salih HR, Maurer S, Hinterleitner C. 2021. Platelet-expressed immune checkpoint regulator GITRL in breast cancer. Cancer Immunol Immunother. 2021 Feb 4. doi: 10.1007/s00262-021-02866-y Zhou K, Zhu X, Ma K, Liu J, Nürnberg B, Gawaz M, Lang F. Effect of MgCl 2 and GdCl 3 on ORAI1 Expression and Store-Operated Ca 2+ Entry in Megakaryocytes. Int J Mol Sci. 2021 Mar 24;22(7):3292. doi: 10.3390/ijms22073292. PMID: 33804889

2020

Balkenhol J, Kaltdorf KV, Mammadova-Bach E, Braun A, Nieswandt B, Dittrich M, Dandekar T. 2020. Comparison of the central human and mouse platelet signaling cascade by systems biological analysis. BMC Genomics 21(1):897.

Bächer C, Bender M, Gekle S. Flow-accelerated platelet biogenesis is due to an elasto-hydrodynamic instability. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):18969-18976.
doi: 10.1073/pnas.2002985117. Epub 2020 Jul 27.

Becker IC, Scheller I, Wackerbarth LM, et al. Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1. Blood Adv. 2020;4(10):2124-2134.
doi:10.1182/bloodadvances.2019001303

Cebo M, Fu X, Gawaz M, Chatterjee M, Lämmerhofer M. 2020 Micro-UHPLC-MS/MS method for analysis of oxylipins in plasma and platelets. J Pharm Biomed Anal. 10; 189:113426.

Cebo M, Fu X, Gawaz M, Chatterjee M, Lämmerhofer M. 2020 Enantioselective ultra-high-performance liquid chromatography-tandem mass spectrometry method based on sub-2µm particle polysaccharide column for chiral separation of oxylipins and its application for the analysis of autoxidized fatty acids and platelet releasates. J Chromatogr A. 1624:461206.

Chatterjee M. Platelet lipidome: Dismantling the “Trojan horse” in the bloodstream. J Thromb Haemost. 2020;18(3):543-557.
doi:10.1111/jth.14721

Colberg L, Cammann C, Greinacher A, Seifert U. Structure and function of the ubiquitin-proteasome system in platelets. J Thromb Haemost. 2020;18(4):771-780.
doi:10.1111/jth.14730

Cullmann K, Jahn M, Spindler M, Schenk F, Manukjan G, Mucci A, Steinemann D, Boller K, Schulze H, Bender M, Moritz T, Modlich U. Forming megakaryocytes from murine-induced pluripotent stem cells by the inducible overexpression of supporting factors. Res Pract Thromb Haemost. 2020 Dec 3;5:111-124. doi: 10.1002/rth2.12453. eCollection 2021 Jan.

Eekels JJM, Pachler C, Krause N, Muhr T, Waltl G, Greinacher A. Ticagrelor causes false-negative functional tests for heparin-induced thrombocytopenia. Blood. 2020;135(11):875-878.
doi:10.1182/blood.2019003582

Essig F, Kollikowski AM, Pham M, Solymosi L, Stoll G, Haeusler KG, Kraft P, Schuhmann MK. Immunohistological Analysis of Neutrophils and Neutrophil Extracellular Traps in Human Thrombemboli Causing Acute Ischemic Stroke. Int J Mol Sci. 2020 Oct 7;21(19):7387.
doi: 10.3390/ijms21197387. PMID: 33036337; PMCID: PMC7582743.

Gorelashvili MG, Angay O, Hemmen K, Klaus V, Stegner D, Heinze KG. Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics. Haematologica. 2020;105(4):895-904.

doi:10.3324/haematol.2018.202010

Green HLH, Zuidscherwoude M, Alenazy F, Smith CW, Bender M, Thomas SG. SMIFH2 inhibition of platelets demonstrates a critical role for formin proteins in platelet cytoskeletal dynamics. J Thromb Haemost. 2020 Jan 13.
doi: 10.1111/jth.14735. [Epub ahead of print]

Heinzmann D, Noethel M, Ungern-Sternberg SV, Mitroulis I, Gawaz M, Chavakis T, May AE, Seizer P. CD147 is a Novel Interaction Partner of Integrin αMβ2 Mediating Leukocyte and Platelet Adhesion. Biomolecules 2020; 10(4):541.
DOI: 10.3390/biom10040541

Jahn K, Handtke S, Palankar R, Weißmüller S, Nouailles G, Kohler TP, Wesche J, Rohde M, Heinz C, Aschenbrenner AF, Wolff M,  Schüttrumpf J, Witzenrath M, Hammerschmidt S*, Greinacher A*. 2020. Pneumolysin induces platelet destruction, not platelet activation, which can be prevented by immunoglobulin preparations in vitro. Blood Adv 4 (24): 6315–6326.
doi: 10.1182/bloodadvances.2020002372 

Kollikowski AM, Schuhmann MK, Nieswandt B, Müllges W, Stoll G, Pham M. Local Leukocyte Invasion during Hyperacute Human Ischemic Stroke. Ann Neurol. 2020 Mar;87(3):466-479.
doi: 10.1002/ana.25665. Epub 2020 Jan 16. PMID: 31899551.

Köhler D, Granja T, Volz J, et al. Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. Nat Commun. 2020;11(1):1315. Published 2020 Mar 11.
doi:10.1038/s41467-020-14958-x

Levi M, Epshtein M, Castor T, Gawaz M, Korin N. Glycoprotein VI (GPVI)-functionalized nanoparticles targeting arterial injury sites under physiological flow. Nanomedicine. 2020;29:102274.
DOI: 10.1016/j.nano.2020.102274

Maguire PB, Parsons ME, Szklanna PB, Zdanyte M, Münzer P, Chatterjee M, Wynne K, Rath D, Comer SP, Hayden M, Ní Áinle F, Gawaz M. Comparative Platelet Releasate Proteomic Profiling of Acute Coronary Syndrome versus Stable Coronary Artery Disease. Front Cardiovasc Med. 2020;7:101.
DOI: 10.3389/fcvm.2020.00101

Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, et al. Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3. Blood. 2020;135(14):1146-1160.
doi:10.1182/blood.2019002649

Nguyen TH, Xu Y, Brandt S, et al. Characterization of the interaction between platelet factor 4 and homogeneous synthetic low molecular weight heparins. J Thromb Haemost. 2020;18(2):390-398.
doi:10.1111/jth.14657

Nicolai L, Schiefelbein K, Lipsky S, Leunig A, Hoffknecht M, Pekayvaz K, Raude B, Marx C, Ehrlich A, Pircher J, Zhang Z, Saleh I, Marel AK, Löf A, Petzold T, Lorenz M, Stark K, Pick R, Rosenberger G, Weckbach L, Uhl B, Xia S, Reichel CA, Walzog B, Schulz C, Zheden V, Bender M, Li R, Massberg S, Gaertner F. Vascular surveillance by haptotactic blood platelets in inflammation and infection. Nat Commun 2020 Nov 13;11:5778.
doi: 10.1038/s41467-020-19515-0.

Pelzl L, Sahu I, Ma K, Heinzmann D, Bhuyan AAM, Al-Maghout T, Sukkar B, Sharma Y, Marini I, Rigoni F, Artunc F, Cao H, Gutti R, Voelkl J, Pieske B, Gawaz M, Bakchoul T, Lang F. Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca2+ Entry in Megakaryocytes. Sci Rep 2020;10:1728.
DOI: 10.1038/s41598-020-58384-x

Peng B, Kopczynski D, Pratt BS, Ejsing CS, Burla B, Hermansson M, Benke PI, Tan SH, Chan MY, Torta F, Schwudke D, Meckelmann SW, Coman C, Schmitz OJ, MacLean B, Manke MC, Borst O, Wenk MR, Hoffmann N, Ahrends R. LipidCreator workbench to probe the lipidomic landscape. Nat Commun. 2020:11(1):2057.
DOI: 10.1038/s41467-020-15960-z

Rath D, Petersen-Uribe Á, Avdiu A, Witzel K, Jaeger P, Zdanyte M, Heinzmann D, Tavlaki E, Müller K, Gawaz MP. Impaired cardiac function is associated with mortality in patients with acute COVID-19 infection. Clin Res Cardiol 2020; 109(12): 1491-1499;
DOI: 10.1007/s00392-020-01683-0

Rath D, von Ungern-Sternberg S, Heinzmann D, et al. Platelet surface expression of cyclophilin A is associated with increased mortality in patients with symptomatic coronary artery disease. J Thromb Haemost. 2020;18(1):234-242.
doi:10.1111/jth.14635

Rheinlaender J and T.E. Schäffer. The effect of finite sample thickness in scanning ion conductance microscopy stiffness measurements.
Applied Physics Letters 117, 113701 (2020)

Scheller I, Stritt S, Beck S, et al. Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets. Haematologica. 2020;105(6):1667-1676.
doi:10.3324/haematol.2019.225516

Schneider F, Horowitz A, Lesch KP, Dandekar T. Delaying memory decline: different options and emerging solutions. Transl Psychiatry. 2020;10(1):13. Published 2020 Jan 21.
doi:10.1038/s41398-020-0697-x

Schuhmann MK, Stoll G, Bieber M, Vögtle T, Hofmann S, Klaus V, Kraft P, Seyhan M, Kollikowski AM, Papp L, Heuschmann PU, Pham M, Nieswandt B, Stegner D. CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke. Circ Res. 2020 Sep 25;127(8):1023-1035.
doi: 10.1161/CIRCRESAHA.120.316655. Epub 2020 Jul 30. PMID: 32762491; PMCID: PMC7508294.

Shityakov S, Bencurova E, Förster C, Dandekar T. 2020. Modeling of shotgun sequencing of DNA plasmids using experimental and theoretical approaches. BMC Bioinformatics 21(1):132.

Shityakov S, Fischer A, Su KP, Hussein AA, Dandekar T, Broscheit J. Novel approach for characterizing propofol binding affinities to 2 serum albumins from different species. ACS Omega Article ASAP.
doi: 10.1021/acsomega.0c01295

Stelzner K, Winkler AC, Liang C, Boyny A, Ade CP, Dandekar T, Fraunholz MJ, Rudel T. 2020. Intracellular Staphylococcus aureus Perturbs the Host Cell Ca++ Homeostasis To Promote Cell Death. mBio 11(6):e02250-20.

Stoll G, Pham M. Beyond recanalization – a call for action in acute stroke. Nat Rev Neurol. 2020 Nov;16(11):591-592.
doi: 10.1038/s41582-020-00417-0. PMID: 32968233.

Volz J, Kusch C, Beck S, Popp M, Vögtle T, Meub M, Scheller I, Heil HS, Preu J, Schuhmann MK, Hemmen K, Premsler T, Sickmann A, Heinze KG, Stegner D, Stoll G, Braun A, Sauer M, Nieswandt B. BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation. J Clin Invest. 2020 Aug 4:136457.
doi: 10.1172/JCI136457. Epub ahead of print. PMID: 32750041.

Wolff M, Handtke S, Palankar R, Wesche J, Kohler TP, Kohler C, Gruel Y, Hammerschmidt S, Greinacher A. 2020. Activated platelets kill Staphylococcus aureus, but not Streptococcus pneumoniae – The role of FcγRIIa and platelet factor 4/heparin antibodies. J Thromb Haemost. 18(6):1459-1468.
doi: 10.1111/jth.14814.

2019

Binsker U, Kohler TP, and Hammerschmidt S. Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria. 2019 Feb 27. J Innate Immun 11:303-315. (Review).
doi: 10.1159/000496033

Breitenbach T, Liang C, Beyersdorf N, Dandekar T. Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks. PLoS Comput Biol. 2019;15(7):e1007075. Published 2019 Jul 16.
doi:10.1371/journal.pcbi.1007075

Breitenbach T, Lorenz K, Dandekar T. How to Steer and Control ERK and the ERK Signaling Cascade Exemplified by Looking at Cardiac Insufficiency. Int J Mol Sci. 2019;20(9):2179. Published 2019 May 2.
doi:10.3390/ijms20092179

Cebo M, Schlotterbeck J, Gawaz M, Chatterjee M, Lämmerhofer M. Simultaneous targeted and untargeted UHPLC-ESI-MS/MS method with data-independent acquisition for quantification and profiling of (oxidized) fatty acids released upon platelet activation by thrombin. Anal Chim Acta. 2020;1094:57-69.
doi:10.1016/j.aca.2019.10.005

Dubrovin EV, Barinov NA, Schäffer TE, Klinov DV. In Situ Single-Molecule AFM Investigation of Surface-Induced Fibrinogen Unfolding on Graphite. Langmuir. 2019;35(30):9732-9739.
doi:10.1021/acs.langmuir.9b01178

Eekels JJM, Althaus K, Bakchoul T, et al. An international external quality assessment for laboratory diagnosis of heparin-induced thrombocytopenia. J Thromb Haemost. 2019;17(3):525-531.
doi:10.1111/jth.14383

Geue S, Aurbach K, Manke MC, et al. Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis. Blood. 2019;134(21):1847-1858.
doi:10.1182/blood.2019000185

Gorelashvili MG, Angay O, Hemmen K, Klaus V, Stegner D, Heinze KG. Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics. Haematologica. 2019 Jun 27. pii: haematol.2018.202010. 
doi: 10.3324/haematol.2018.202010. [Epub ahead of print] PubMed PMID: 31248970.

Greinacher A, Eekels JJM. Diagnosis of hereditary platelet disorders in the era of next-generation sequencing: “primum non nocere”. J Thromb Haemost. 2019;17(3):551-554.
doi:10.1111/jth.14377

Greinacher A, Eekels JJM. Simplifying the diagnosis of inherited platelet disorders? The new tools do not make it any easier. Blood. 2019;133(23):2478-2483.
doi:10.1182/blood-2019-01-852350

Handtke S, Steil L, Palankar R, et al. Role of Platelet Size Revisited-Function and Protein Composition of Large and Small Platelets. Thromb Haemost. 2019;119(3):407-420.
doi:10.1055/s-0039-1677875

Heinzmann D, Klingel K, Müller K, Kumbrink J, Kirchner T, Schreieck J, Gawaz M, Seizer P. Mitochondrial Dynamics in Tachycardiomyopathy. Cell Physiol Biochem. 2019;52(3):435-438.
doi: 10.33594/000000031. Epub 2019 Mar 15. PubMed PMID: 30873819.

Körner A, Schlegel M, Kaussen T, et al. Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A. Nat Commun. 2019;10(1):633. Published 2019 Feb 7.
doi:10.1038/s41467-019-08328-5

Kollikowski AM, Amaya F, Stoll G, Müllges W, Schuhmann MK, Pham M. Impact of landmark endovascular stroke trials on logistical performance measures: a before-and-after evaluation of real-world data from a regional stroke system of care. J Neurointerv Surg. 2019;11(6):563-568.
doi:10.1136/neurintsurg-2018-014286

Kiran Gotru S, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM, Braun A. Defective Zn(2+) homeostasis in mouse and human platelets with α- and δ-storage pool diseases. Sci Rep. 2019 Jun 6;9(1):8333.
doi: 10.1038/s41598-019-44751-w. PubMed PMID: 31171812

Krauel K, Preuße P, Warkentin TE, et al. Fibronectin modulates formation of PF4/heparin complexes and is a potential factor for reducing risk of developing HIT. Blood. 2019;133(9):978-989.
doi:10.1182/blood-2018-05-850370

Nguyen TH, Wesche J, Raschke R, Strobel U, Bui VC, Delcea M, Greinacher A. Reactivity of platelet-activating and nonplatelet-activating anti-PF4/heparin antibodies in enzyme immunosorbent assays under different conditions. J Thromb Haemost. 2019 Jul;17(7):1113-1119.
doi: 10.1111/jth.14455. Epub 2019 May 17. PubMed PMID: 31009154.

Sauter RJ, Sauter M, Obrich M, et al. Anaphylatoxin Receptor C3aR Contributes to Platelet Function, Thrombus Formation and In Vivo Haemostasis. Thromb Haemost. 2019;119(1):179-182.
doi:10.1055/s-0038-1676349

Schuhmann MK, Kraft P, Bieber M, Kollikowski AM, Schulze H, Nieswandt B, Pham M, Stegner D, Stoll G. Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice. Int J Mol Sci. 2019 Apr 24;20(8). pii: E2019.
doi: 10.3390/ijms20082019. PubMed PMID: 31022936; PubMed Central

Schuhmann MK, Stoll G, Bohr A, Volkmann J, Fluri F. Electrical Stimulation of the Mesencephalic Locomotor Region Attenuates Neuronal Loss and Cytokine Expression in the Perifocal Region of Photothrombotic Stroke in Rats. Int J Mol Sci. 2019 May 11;20(9). pii: E2341. 
doi: 10.3390/ijms20092341. PubMed PMID: 31083528

Schuhmann MK, Stoll G, Papp L, Bohr A, Volkmann J, Fluri F. Electrical Stimulation of the Mesencephalic Locomotor Region Has No Impact on Blood-Brain Barrier Alterations after Cerebral Photothrombosis in Rats. Int J Mol Sci. 2019 Aug 19;20(16). pii: E4036.
doi: 10.3390/ijms20164036. PubMed PMID: 31430854

Schurr Y, Sperr A, Volz J, et al. Platelet lamellipodium formation is not required for thrombus formation and stability. Blood. 2019;134(25):2318-2329.
doi:10.1182/blood.2019002105 

Schurr Y, Spindler M, Kurz H, Bender M. The cytoskeletal crosslinking protein MACF1 is dispensable for thrombus formation and hemostasis. Sci Rep. 2019;9(1):7726. Published 2019 May 22.
doi:10.1038/s41598-019-44183-6

Semeniak D, Faber K, Öftering P, Manukjan G, Schulze H. Impact of Itga2-Gp6-double collagen receptor deficient mice for bone marrow megakaryocytes and platelets. PLoS One. 2019;14(8):e0216839. Published 2019 Aug 9.
doi:10.1371/journal.pone.0216839

Shvedova M, Litvak MM, Roberts JD Jr, Fukumura D, Suzuki T, Şencan İ, Li G, Reventun P, Buys ES, Kim HH, Sakadžić S, Ayata C, Huang PL, Feil R, Atochin DN. cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice. J Cereb Blood Flow Metab. 2019 Aug 18:271678X19870583.
doi: 10.1177/0271678X19870583. [Epub ahead of print] PubMed PMID: 31423931.

Simeonov S , Schäffer TE . High-speed scanning ion conductance microscopy for sub-second topography imaging of live cells. Nanoscale. 2019;11(17):8579-8587.
doi:10.1039/c8nr10162k

Stegner D, Hofmann S, Schuhmann MK, Kraft P, Herrmann AM, Popp S, Höhn M, Popp M, Klaus V, Post A, Kleinschnitz C, Braun A, Meuth SG, Lesch KP, Stoll G, Kraft R, Nieswandt B. Loss of Orai2-Mediated Capacitative Ca(2+) Entry Is Neuroprotective in Acute Ischemic Stroke. Stroke. 2019 Nov;50(11):3238-3245.
doi: 10.1161/STROKEAHA.119.025357. Epub 2019 Sep 25. PubMed PMID: 31551038.

Stoll G, Nieswandt B. Thrombo-inflammation in acute ischaemic stroke – implications for treatment. Nat Rev Neurol. 2019 Jul 1.
doi: 10.1038/s41582-019-0221-1. [Epub ahead of print] Review. PubMed PMID: 31263257.

Volz J, Mammadova-Bach E, Gil-Pulido J, et al. Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice. Blood. 2019;133(25):2696-2706.
doi:10.1182/blood.2018877043

2018

Droppa M, Borst O, Katzenberger T, Krause R, Bramlage K, Bramlage P, Lausberg HF, Schlensak C, Grasshoff C, Gawaz M, Geisler T. Clinical and economical impact of the presence of an extended heart team throughout the balloon-expandable transcatheter aortic valve implantation procedure. Clin Res Cardiol. 2018 Aug 24.doi: 10.1007/s00392-018-1359-3. [Epub ahead of print] PubMed PMID: 30167808

Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. 2018. TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice. Arterioscler Thromb Vasc Biol 38(2):344-352.

Peng B, Geue S, Coman C, Münzer P, Kopczynski D, Has C, Hoffmann N, Manke MC, Lang F, Sickmann A, Gawaz M, Borst O, Ahrends R. Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome. Blood. 2018 Aug 2;132(5):e1-e12. doi: 10.1182/blood-2017-12-822890. Epub 2018 May 21. PubMed PMID: 29784642; PubMed Central PMCID: PMC6137561.

Sauter RJ, Sauter M, Reis ES, Emschermann FN, Nording H, Ebenhöch S, Kraft P, Münzer P, Mauler M, Rheinlaender J, Madlung J, Edlich F, Schäffer TE, Meuth SG, Düerschmied D, Geisler T, Borst O, Gawaz M, Kleinschnitz C, Lambris JD, Langer HF. A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis. Circulation. 2018 May 25. pii:CIRCULATIONAHA.118.034600. doi: 10.1161/CIRCULATIONAHA.118.034600. [Epub ahead of print] PubMed PMID: 29802205

Spindler M, van Eeuwijk JMM, Schurr Y, Nurden P, Nieswandt B, Stegner D, Reinhold A, Bender M. ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia. Blood. 2018 Aug 9;132(6):635-646. doi: 10.1182/blood-2018-01-829259. Epub 2018 Jun 27. PubMed PMID: 29950291