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The Chair of Experimental Biomedicine I,
University Hospital Würzburg and Rudolf-Virchow-Center/University Würzburg, Germany, invites applications for

1 PhD student position (f/m/d)

to target immune cell-platelet interactions in ischemic stroke embedded in the DFG-funded Collaborative Research Center CRC/TR 240 “Platelets – Molecular, cellular and systemic functions in health and disease”.

Our interdisciplinary research team investigates the cellular and molecular mechanisms of ischemic stroke, one of the most common causes of physical disability worldwide. Apart from the contribution of the platelets to the primary vascular occlusion, they are also significantly involved in the regulation of “thrombo-inflammatory” processes, the interaction between platelets and immune cells, and the resulting brain damage. We recently identified CD84 as one molecule linking platelet and T cell activity in the ischemic brain (Schuhmann et al., Circ Res 2020).

Activities and responsibilities

We are seeking a highly motivated PhD student to work on a project that combines in vitro and in vivo models of ischemic stroke with functional cellular assays as well as biochemical and molecular biology approaches. Moreover, in a translational approach, antibodies against newly identified targets, such as CD84, will be generated and characterized using genetically modified mice.

Qualification profile

Suitable candidates should hold a Master’s degree or equivalent in a life sciences subject with a strong interest in molecular and (vascular) cell biology/immunology, mouse models and cell culture. Excellent lab skills and good knowledge of the English language are a prerequisite. Previous experience with in vivo work and/or hybridoma cell culture is highly advantageous.

Benefits

We offer an international and excellent scientific environment that is embedded in the framework of a German wide research consortium on platelets. Its infrastructure is unique in the platelet research field and offers the opportunity to collaborate with national and international basic and translational research groups. The department involves several research labs consisting of post-doctoral scientists, PhD students, master students and research assistants and comes along with a pleasant working atmosphere.

As a PhD student you will have the opportunity to become part of the international ‘Graduate School of Life Sciences’ (GSLS). The university furthermore offers comprehensive services concerning administrative and practical matters, e.g. the Welcome Centre (moving to Würzburg) and the International Office.

The salary for this temporary position is commensurate with training and experience according to Collective Agreement for the Public Service of German Federal States TV-L (E13 (65%). We particularly encourage female scientists to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.

Send applications to

The position will start on March 1st, 2022 or later. Applications should be sent as a single pdf-document including application letter, curriculum vitae, certificates including contact details of two references by e-mail until January 31st, 2022 to Prof. Dr. David Stegner (career@platelets.eu).

For further questions, please do not hesitate to contact Prof. Dr. David Stegner (stegner@virchow.uni-wuerzburg.de).