Non-invasive multiparametric small animal imaging enables the investigation of molecular and functional processes and reveals detailed morphology in vivo. Technologies provided by this core unit include measurements of platelet tracking, glucose metabolism, fatty acid metabolism, cell proliferation, hypoxia or angiogenesis by positron emission tomography (PET) or optical bioluminescence and fluorescence imaging (optical imaging – OI). We will use a variety of radiolabelled biomarkers (small molecules, peptides and antibodies) which are either well established in our radiopharmacy laboratory or will be developed within the frame of this consortium. High-resolution morphology and functional changes (perfusion, diffusion, etc.) will be assessed by magnetic resonance imaging (MRI). In addition we will also provide high-resolution nuclear magnetic resonance (NMR) spectroscopy where appropriate and needed to quantify metabolic profiles related to platelet processes. Innovative machine learning methods are established in our lab and will be used for multiparametric and quantitative image analysis. At least nine sub-projects of this SFB will benefit from our small animal imaging center.
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