Project area B: Platelets als regulators and effectors in disease

B02 – Platelet-dependent injury and safeguard mechanisms in acute ischaemic stroke

After mechanical thrombectomy (MT) in acute stroke, ischaemia/reperfusion (I/R) injury and haemorrhagic transformation (HT) determine further outcome. We will analyse platelet function impairing collateral blood flow and reperfusion during/after transient middle cerebral artery occlusion in mice, and discern platelet functions indispensable for sealing the blood-brain-barrier and preventing HT in the ischaemic brain, complemented by analysis of human platelets locally retrieved during MT.


Stoll Guido
Prof. Dr. med.
Stoll, Guido
Board member, B02
Pham Mirko Porträt
Prof. Dr. med.
Pham, Mirko
Direktor, B02