Hallmarks of the Acute Respiratory Distress Syndrome (ARDS) are the intra-alveolar inflammation and the impairment of pulmonary barrier function. The interaction of platelets with neutrophils is crucial for this process and can be influenced by Neuronal Guidance Proteins (NPGs). Platelets also affect T cell function, a process important for pulmonary inflammation. We plan to dissect the molecular mechanisms of platelet-orchestrated immune processes during ARDS. For this, we will utilise a broad range of genetically modified mouse models, pharmacological tools and advanced imaging methods.