Blood platelets are anucleated cell fragments that are essential for blood clotting. They are produced by large precursor cells residing in the bone marrow (BM),

In this project we aim to investigate the role of Casein kinase (CK) 1 and 2 dependent signalling pathways involved in MK development with regulation

While total body irradiation is essential to eradicate malignant cells and to generate niche sites for a donor-derived new haematopoietic system, it also destroys the

Platelets are produced by bone marrow megakaryocytes (MKs), which extend long cytoplasmic pro-trusions, designated proplatelets, into sinusoidal blood vessels where these proplatelets undergo fission to

NO-induced elevation of cGMP and cGMP-elevating drugs modulate platelet activity, but the molecular mechanisms and therapeutic potential of cGMP signalling in platelets are not well

Circulating platelets are essential players in haemostasis and thrombosis, as they “survey” the integrity of the vascular system. Upon vascular injury, platelets rapidly adhere to

We have discovered that distinct antibodies efficiently trigger a new mechanism of platelet receptor regulation in vivo, namely the ´disintegration´ (uncoupling) of cytoskeleton-connected trans­membrane proteins,

This project will focus on regulation of the platelet lipidome. We will characterise the molecular mechanisms governing platelet lipid metabolism and its functional consequences on

Although Zn2+ metabolism including catalytic, regulatory and structural functions has received extensive attention, the molecular mechanisms that control cellular Zn2+ homeostasis remain poorly defined in

Platelets modulate bacterial infections. We will identify platelet-activating factors of Staphylococcus aureus and Streptococcus pneumoniae and identify involved platelet receptors and signalling pathways. We established