Project B01 (Gawaz/Langer) explores the roles of platelet CXCL-chemokines and CXC-receptors on thrombo-inflammation following organ ischemia (heart and brain). Further, the importance of platelet-CXCL/CXCR-axis for recovery of the failing ischemic myocardium using a variety of genetic mouse strains will be elaborated. We will mirror our experimental results with clinical studies of patients with acute myocardial ischemia. The project is aimed to develop novel therapeutic strategies for ischemic organ dysfunction with currently limited treatment options.
